グリコシルトランスフェラーゼ
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/11/11 07:34 UTC 版)
グリコシルトランスフェラーゼまたは糖転移酵素(とうてんいこうそ、英: glycosyltransferase)は、グリコシド結合を形成する酵素(EC 2.4)である。活性化された糖ヌクレオチド(糖供与体と呼ばれる)から糖部分を求核的な糖受容体へ転移する過程を触媒する。求核剤は酸素、炭素、窒素、硫黄系の場合がある[1]。
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- ^ Transferases in Membranome database.
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- ^ Zhang, C; Albermann, C; Fu, X; Thorson, JS (27 December 2006). “The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility.”. Journal of the American Chemical Society 128 (51): 16420–1. doi:10.1021/ja065950k. PMID 17177349.
- ^ Zhang, C; Fu, Q; Albermann, C; Li, L; Thorson, JS (5 March 2007). “The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification.”. ChemBioChem: A European Journal of Chemical Biology 8 (4): 385–90. doi:10.1002/cbic.200600509. PMID 17262863.
- ^ Zhang, C; Moretti, R; Jiang, J; Thorson, JS (13 October 2008). “The in vitro characterization of polyene glycosyltransferases AmphDI and NysDI.”. ChemBioChem: A European Journal of Chemical Biology 9 (15): 2506–14. doi:10.1002/cbic.200800349. PMC 2947747. PMID 18798210 .
- ^ Gantt, RW; Peltier-Pain, P; Cournoyer, WJ; Thorson, JS (21 August 2011). “Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions.”. Nature Chemical Biology 7 (10): 685–91. doi:10.1038/nchembio.638. PMC 3177962. PMID 21857660 .
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- ^ Chang, A; Singh, S; Phillips GN, Jr; Thorson, JS (December 2011). “Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation”. Current Opinion in Biotechnology 22 (6): 800–8. doi:10.1016/j.copbio.2011.04.013. PMC 3163058. PMID 21592771 .
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- ^ Kocev, A; Melamed, J; Wang, S; Kong, X; Vlahakis, JZ; Xu, Y; Szarek, WA; Brockhausen, I (June 2020). "Inhibition of bacterial growth and galactosyltransferase activity of WbwC by α, ω-bis(3-alkyl-1H-imidazolium)alkane salts: Effect of varying carbon content". Bioorganic and Medicinal Chemistry. 28 (11): 115494. doi:10.1016/j.bmc.2020.115494. PMID 32312486.
- ^ Gantt, RW; Peltier-Pain, P; Thorson, JS (October 2011). “Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.”. Natural Product Reports 28 (11): 1811–53. doi:10.1039/c1np00045d. PMID 21901218.
- 1 グリコシルトランスフェラーゼとは
- 2 グリコシルトランスフェラーゼの概要
- 3 配列による分類
- 4 利用
- グリコシルトランスフェラーゼのページへのリンク