長鎖散在反復配列
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/09/18 09:28 UTC 版)
長鎖散在反復配列(ちょうささんざいはんぷくはいれつ、英: long interspersed nuclear element, LINE)とは、非LTR型レトロトランスポゾンの一群である。多くの真核生物のゲノムに広く見られ[1][2]、ヒトゲノムでは全体のおよそ21.1%を占める[3][4][5]。それぞれの長さはおおよそ7000塩基対程度である。mRNAへ転写されたのち、逆転写酵素活性を持つタンパク質へと翻訳される。この逆転写酵素によりLINE RNAからコピーされたDNAのゲノム上における新しいサイトへの組み込みが可能となる。
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