カスパーゼ-1
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2021/06/12 15:02 UTC 版)
カスパーゼ-1（英: caspase-1）は進化的に保存された酵素であり、炎症性サイトカインであるインターロイキン-1β（IL-1β）、インターロイキン-18（IL-18）前駆体のタンパク質分解による切断や、ピロトーシスの誘導因子であるガスダーミンDの活性型成熟ペプチドへの切断を行う[5][6][7]。インターロイキン-1β変換酵素（interleukin-1β converting enzyme、ICE）としても知られる。カスパーゼ-1は、炎症応答の開始因子として細胞性免疫に中心的な役割を果たす。カスパーゼ-1はインフラマソーム複合体の形成を介して活性化されると、IL-1βとIL-18の2つの炎症性サイトカインの切断・活性化によって炎症促進応答を開始するとともに、ガスダーミンDの切断によって溶解性プログラム細胞死経路であるピロトーシスを開始する[8]。カスパーゼ-1によって活性化された2つの炎症性サイトカインは細胞から分泌され、さらに近隣の細胞での炎症応答を誘導する[9]。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000137752 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025888 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
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- ^ “Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin”. The Journal of Biological Chemistry 290 (52): 31151–61. (December 2015). doi:10.1074/jbc.M115.680694. PMC: 4692238. PMID 26559977.
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- ^ “Entrez Gene: CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)”. 2021年6月12日閲覧。
- ^ “Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection”. Nature 505 (7484): 509–14. (January 2014). doi:10.1038/nature12940. PMC: 4047036. PMID 24356306.
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- ^ “mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a”. Journal of Immunology 201 (2): 371–382. (July 2018). doi:10.4049/jimmunol.1701712. PMC: 6039264. PMID 29866702.
[続きの解説]
「カスパーゼ-1」の続きの解説一覧
- 1 カスパーゼ-1とは
- 2 カスパーゼ-1の概要
- 3 細胞での発現
- 4 関連項目
- カスパーゼ1のページへのリンク
