Obstetrics and Gynecology,
Cancer Biology
Chemical Biology
IYOSHI Shohei
Starting year 2024
Nagoya University
Institute for Advanced Research/Graduate School of Medicine, Department of Obstetrics and Gynecology
YLC Designated Assistant Professor
Research fields
Research Interests
Gynecological tumors
Ovarian cancer
Adipocytes
Women’s medicine
Professional Memberships
Japan Society of Obstetrics and Gynecology(JSOG)
Japan Society of Gynecologic Oncology(JSGO)
Japan Society for Reproductive Medicine(JSRM)
The Japan Society for Menopause and Women’s Health(JMWH)
Japanese Cancer Association(JCA)
Japan Society of Clinical Oncology(JSCO)
Japanese Society of Anti-Aging Medicine
Japan Society for Fertility Preservation(JSFP)
Main research topics
Ovarian cancer (OvCa) is one of the most prognostically unfavorable tumors in the field of gynecologic oncology. Due to the lack of noticeable symptoms and the absence of established screening method, many cases are found in advanced stages with multiple metastatic nodules in abdominal cavity, especially at abdominal adipose tissue, known as peritoneal dissemination. It is believed that OvCa cells interact with adipocytes and ascites fluid at metastatic sites to acquire energy or drug resistance needed for further metastasis, however, the details of the entire mechanism have not yet been elucidated. So far, I have identified the novel cancer promoting mechanism related to the dedifferentiation of omental adipocyte. Also, from clinical research, I revealed that obesity becomes independent risk factor for peritoneal recurrence of OvCa.
The “Seed and Soil” theory of cancer metastasis, proposed by Stephen Paget, posits that the spread of cancer depends on the properties of cancer cells (the “seeds”) and the environment of the target organ (the “soil”). Metastasis occurs when cancer cells find a compatible microenvironment in the target organ that supports their growth. My research aims to understand the nature of the intra-abdominal ecosystem as an OvCa-promoting “soil” interwoven with interactions between OvCa cells, adipose tissue, and malignant ascites, and to target it for the development of novel OvCa treatment.
Representative papers
(1) Iyoshi, S. et al. Pro-tumoral behavior of omental adipocyte-derived fibroblasts in tumor microenvironment at the metastatic site of ovarian cancer. Int. J. Cancer 149, 1961–1972 (2021)
(2) Iyoshi, S. et al. Obesity contributes to the stealth peritoneal dissemination of ovarian cancer: a multi-institutional retrospective cohort study. Obesity 30, 1599–1607 (2022)
Research URL
researchmap https://researchmap.jp/iyoshi
Global issues to be solved through this project
LipoQuality in women’s health care
In modern society with excessive stress and irregular lifestyles, addressing the health risks associated with overweight or underweight is becoming increasingly important, especially in the field of women’s health care for achieving the gender equality. Weight loss or obesity are caused by the shrinkage or hypertrophy of adipocytes in adipose tissue. Qualitative changes in lipids constituting adipocytes are called “LipoQuality” changes, and their roles and significance in various diseases have been attracting attention in recent years. In this project, the significance of LipoQuality changes in the field of clinical gynecology will be examined by multiple approaches including chemical biology and multi-omics.
Interview
No interview