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. 2017 May;57(3):72-78.
doi: 10.1111/cga.12202.

Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study

Hidekazu Nishigori  1   2 , Taku Obara  3   2   4 , Toshie Nishigori  1 , Satoshi Mizuno  2   4 , Hirohito Metoki  4   5 , Tetsuro Hoshiai  1 , Zen Watanabe  1 , Kasumi Sakurai  2 , Mami Ishikuro  4 , Nozomi Tatsuta  2 , Ichiko Nishijima  2   4 , Ikuma Fujiwara  2 , Shinichi Kuriyama  2   4   6 , Takahiro Arima  2 , Kunihiko Nakai  2 , Nobuo Yaegashi  1   2   4 ; Japan Environment & Children's Study Group
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Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study

Hidekazu Nishigori et al. Congenit Anom (Kyoto). 2017 May.

Abstract

We analyzed data from the Japan Environment and Children's Study (JECS), on the association between selective serotonin reuptake inhibitors (SSRI) use during pregnancy and the risk of developing of major congenital anomalies in Japan. JECS is an ongoing nationwide birth cohort study. The study includes 95 994 single pregnant women and their offspring. Among them, 172 used any SSRI up to the 12th gestational week. Crude analyses show a significantly increased incidence of upper limb, abdominal, and urogenital abnormalities. In particular, the incidence of microcephaly, hydrencephalus, esophageal atresia, small intestinal atresia, and achondroplasia was significantly higher with than without exposure to these substances. On multivariate analyses, urogenital abnormality was significant (odds ratio 3.227; 95% confidence interval: 1.460-7.134). This Japanese nationwide birth cohort survey clarified that the use of any SSRI until the 12th gestational week was associated with urogenital abnormality in children. The survey for association with minor classification abnormality needs further examination in Japan.

Keywords: Japan Environment and Children's Study; major congenital anomalies; selective serotonin reuptake inhibitors.

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