Dysfunction of the attentional brain network in children with Developmental Coordination Disorder: a fMRI study - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2008 Dec 9:1244:89-102.
doi: 10.1016/j.brainres.2008.07.066. Epub 2008 Jul 29.

Dysfunction of the attentional brain network in children with Developmental Coordination Disorder: a fMRI study

Laurent Querne  1 , Patrick Berquin, Marie-Pierre Vernier-Hauvette, Sidy Fall, Laetitia Deltour, Marc-Etienne Meyer, Giovanni de Marco
Affiliations
Clinical Trial

Dysfunction of the attentional brain network in children with Developmental Coordination Disorder: a fMRI study

Laurent Querne et al. Brain Res. .

Abstract

Children with Developmental Coordination Disorder (DCD) present impaired motor skills, frequently associated with impaired attentional and executive functions. The objective of this study was to assess the impact of DCD on effective connectivity applied to a putative model of inhibition. fMRI was performed in 9 children with DCD and 10 control children (8-13 years old) performing a go-nogo task. As previously reported, children with DCD obtained a similar score for correct inhibitions as controls, but responses were slower and more variable than in controls. Compared to controls, Structural Equation Modeling indicated that: (1) path coefficients from both middle frontal cortex (MFC) and anterior cingulate cortex (ACC) to inferior parietal cortex (IPC) increased in children with DCD particularly in the left hemisphere; (2) path coefficients between striatum and parietal cortex decreased in children with DCD in the right hemisphere. Results suggest that DCD could be characterized by abnormal brain hemispheric specialization during development. Furthermore, connectivity in the MFC-ACC-IPC network could indicate that children with DCD are less able than healthy children to easily and/or promptly switch between go and nogo motor responses. However, children with DCD seem to compensate for this poor efficiency by more actively engaging the ACC to prevent commissions allowing maintenance of a good level of inhibition.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources