Rł̃XNvt@CFLFtBŁbJ

ЂƁA炵A݂炢̂߂

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Rł̃XNvt@CFLFtB

LFtB

1 LŎ

G]oCȃG]{iNepuneaj̑̎ށiJVG]{N. antiqua [1-3]AqG]{ N. arthritica [2-8]i}1jA AcG]{N. bulbacea [7]A`a~G]{N. constricta [6]A`EZ{Neptunea cumingii [9]ANCG]{N. eulimatalamellosa [7]A RG]{hLN. intersculpta f. frater pilsbry [7]A}G]{hLN. intersculpta f. pribiloffensis [7]A qG]{hL N. kuroshio [10]AElG]{N. lyrata [11, 12]AG]{N. polycostata [6, 8, 11]уtWCG]{N. vinosa [7]j Lłł邱ƂؖĂiG]{̊Lׂ͂ėLłƎvjB̑AG]oCȃG]oC̃XKoC[4]A tWcKCȂ̃A{[5]уeOjVȂ̃eOjV[7]LłłB犪L̓cuƂcuLƂĎŝĂ iG]oC̖ŎcucuLƂėʂĂ̂ŕ킵jBnɂĂ̓G]{hL`a~G]{͐ԃoCƂĂ΂Ă inł́AG]oC̃Gb`EoC𔒃oCƌĂłjBLŕʂ͑tBi}1jɌĂB

qG]{

}1@qG]{̎ʐ^.@FLkƊWAEFނgi͑tBj
2 Ŕ

2003-2023N̒Ŕ󋵂\PɎB

\1@LtBłɂ钆Ŕ󋵁i܂ށBj

N ij Ґilj Ґilj
2003 1 3 0
2004 4 10 0
2005 5 10 0
2006 4 6 0
2007 2 2 0
2008 12 24 0
2009 6 12 0
2010 1 2 0
2011 0 0 0
2012 4 6 0
2013 2 3 0
2014 0 0 0
2015 1 2 0
2016 5 24 0
2017 3 5 0
2018 5 5 0
2019 2 4 0
2020 7 11 0
2021 1 1 0
2022 3 3 0
2023 1 1 0

Nx̒łĂi2008N12ƔɑjBS҂͂ȂB G]{ĹA`EZ{̂悤ɑΔngCɐĂނ邪قƂǂ͊Cł̂ŁAeg~ł] kCⓌknň|IɑBߔNAʂ̍L扻̂߂łL扻̌X݂BႦ2002`2008Nɔ eg~30̂AkCł3Aknł6ŁAc21͂̑̑SenŔĂBȂAŌɂȂ銪L ̂‚܂݂ɂ邱ƂAŏǏiŠjƂ̊֘AŎۂɂ͒łɂƂĂɐƂČ߂ĂP[X Ȃ肠ƎvB
3 ŏǏ H301ԂŔǂAɁA߂܂ADAŠÂӂ‚A̒ɂ݁‚AqfȂǂ݂B ʏ퐔Ԃʼn񕜂AS邱Ƃ͂ȂBɐ悤ȏǏ󂪂邱ƂAL͒nɂĂ͐LƂĒmĂB ܂ACÂƂqG]{̓lcuƂĂ΂ĂB
4 Ő
i1ĵщw\ eg~ (CH3)4N+
i2jwI nBMɑ΂ĈŁAʏ̒ł͓Ő͎ȂB ܂AMɂAtB̃eg~̈ꕔ͋ؓAϏ`Ɉڍs[6, 13]B ɖ𓀂ɂĂeg~̈ꕔ͋ؓɈڍs[13]B
i3jŐ }EXɑ΂LD50ijF24 mg/kgio^jA16 mg/kgio^j[14]
_Jɑ΂ŏvZxijF0.1 mg/ml [15]
i4jŗ eg~̃qgł̒ŗʂ͋{[16]ɂ350`450 mgƂĂB qG]{̏ꍇA1‘̂̑tBdʂ1-2gŃeg~ܗʂ͐mg-10 mg/gł̂ŁAŗʂ͊L20-30‚ɑB Ȃۂɂ͂Ə̊LHׂĂł͔Ă悤ŁA10 mgƂʂłǂ邱Ƃ񍐂[6]B eg~̒ŗʂ50 mgȏiqG]{ˆȏj[10]Ƃ̂ÓƎvB
i5jp@\ N[lpi_o؎Ւfpjѕ_on̎hpBŏǏ͂̍pŐłB
i6j͕@
  • }EXF}EXɕo^ėp-vԋȐʂ@񍐂Ă邪Axѐx̓_œ[15]B
  • Fʖ@FrIȕւł邪AʌE200 g/gŊx͏\ł͂Ȃ[10]B
  • HPLCFȕւł邪Axѓِ̓_œ[17]B
  • Ls[dCj/MS/MSFxioEF20 ng/gj͗ǍDœِA@킪ŔėpɌ[18]B
  • LC/ESI-MSFxioEF10 ng/gj͗ǍDœِ[13]B
5 ő΍ tBΒł͖h~łB
6 Ql tWcKCȂ̃JR{̑tBɂ̓^pNŁiechotoxinjZxɊ܂܂Ă[19]B Echotoxin25 kDa̒P^pNňꎟ\炩ɂĂ邪[20]A60A10 min̉MŊSɓŐ̂ŁAM tBȂĂHiq̖͂ȂƎvBJR{̑AtWcKCȂ̃{EVE{G]oCȂ̃G]oCtB Lłł邱Ƃ񍐂Ă邪[11]AŐɂ‚Ă͂悭킩ĂȂB
7
  1. Fange R.: The salivary gland of Neptune antiqua. Ann. N. Y. Acad. Sci., 90, 689-694 (1960).
  2. Anthoni U, Bohlin L, Larsen C, Nielsen P, Nielsen NH, Christophersen C: The toxin tetramine from the "edible" whelk Neptunea antiqua. Toxicon, 27, 717-723 (1989).
  3. Power AJ, Keegan BF, Nolan K: The seasonality and role of the neurotoxin tetramine in the salivary glands of the red whelk Neptunea antiqua (L.). Toxicon, 40, 419-425 (2002).
  4. Asano M, Ito M: Occurrence of tetramine and choline compounds in the salivary gland of a marine gastropod, Neptunea arthritica Bernardi. Tohoku J Agirc Res, 10, 209-227 (1959).
  5. Asano M, Ito M: Salivary poison of a marine gastropod Neptunea arthritica Bernardi and the seasonal variation of its toxicity. Ann NY Acad Sci, 90, 674-688 (1960).
  6. VN, R, ρ@q, V@, @NT, ㌴^, caj: CIN}gOtB[ɂ銪Li̓jeg~͋̕yђɂ. Hq, 41, 11-16 (2000).
  7. 쓈zq, T, Y: HLtB̓Őуeg~ܗ. Hq, 43, 385-388 (2002).
  8. Kawashima Y, Nagashima Y, Shiomi K: Determination of tetramine in marine gastropods by liquid chromatography/electrospray ionization-mass spectrometry. Toxicon, 44, 185-191 (2004).
  9. qC, Fi, Tq, B, Ԓ, {菺v: `EZ{iNeptunea cumingiij̃eg~ܗʂ̑. qw, 35, 476-478 (1989).
  10. ߎq, Xeq, cK, 쎞F, X@xj, V[i: egutFm[t^CG`GXepLeg~̔F. Hq, 33, 237-240 (1992).
  11. Shiomi K, Mizukami M, Shimakura K, Nagashima Y: Toxins in the salivary gland of some marine carnivorous gastropods. Comp Biochem Physiol, 107B, 427-432 (1994).
  12. cY, Ή^, 쌒, KNT: LtBeg~ܗʂɊւ钲 (2). q, 54, 63-64 (2004).
  13. Kawashima Y, Nagashima Y, Shiomi K: Determination of tetramine in marine gastropods by liquid chromatography/electrospray ionization-mass spectrometry. Toxicon, 44, 185-191 (2004).
  14. Shiomi K, Horiguchi Y, Kaise T: Acute toxicity and rapid excretion in urine of tetramethylarsonium salts found in some marine animals. Appl Organomet Chem, 2, 385-389 (1988).
  15. Kungswan A, Noguchi T, Kano S, Hashimoto K: Assay method for tetramine in carnivorous gastropods. Nippon Suisan Gakkaishi, 47, 881-884 (1986).
  16. {FY: Lނ̓. woŃZ^[, , 1977, pp 24-26.
  17. Hashizume K, Toda C, Yasui T, Nagano H: Determination of tetramine in Neptunea intersculpta by high performance liquid chromatography. Eisei Kagaku, 33, 179-184 (1987).
  18. Zhao J, Thibault P, Tazawa T, Quilliam MA: Analysis of tetramine in sea snails by capillary electrophoresis-tandem mass spectrometry. J Chromatogr A, 781, 555-564 (1997).
  19. Shiomi K, Kawashima Y, Mizukami M, Nagashima Y: Properties of proteinaceous toxins in the salivary gland of the marine gastropod (Monoplex echo). Toxicon, 40, 563-571 (2002).
  20. Kawashima Y, Nagai H, Ishida M, Nagashima Y, Shiomi K: Primary structure of echotoxin 2, an actinoporin-like hemolytic toxin from the salivary gland of the marine gastropod Monoplex echo. Toxicon, 42, 491-497 (2003).

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