Rł̃XNvt@CF񖇊LFLrLŁbJ

ЂƁA炵A݂炢̂߂

z[ > ɂ‚ > ʂ̐ꗗ > NE > Hi > H > Rł̃XNvt@C > Rł̃XNvt@CF񖇊LFLrL

Rł̃XNvt@CF񖇊LFLrL

񖇊LFLrL

1 LŎ

LrLłɂʼn݂ꂽ́A񖇊Lނł̓TLCKCi}PjACKCA z^eKCi}QjA}eKCȂǁAރSECJAbkރ_WlXNuizNEC`EKjjA XxXx}WEKji}RjAރA`r[ȂǂŁAɂېHJtHjAAVJɂ LrLł̒~ς݂ꂽ[1, 2]BLrLł͌]V[hjb`Pseudo-nitzschiaAjb`NitzschiaAAtHAmphoraɂ YAPseudo-nitzschiamultiseriesAPseudo-nitzschiaaustraliAPseudo-nitzschia seriatas̃hEC_Y\B gtW}cȃniiMATSȃJjmeAPqTdLA}TSoVȃjZComȂǂ獂Zx̋LrLłoꂽB

TLKC TLKC
i}P@TLCKCj
z^eKC z^eKC
i}Q@z^eKCj
XxXx}WEKj
i}R@XxXx}WEKjj
2 Ŕ 1987NɃJi_Ŏ3܂107̏WcHł߂Ĕ[3]Ĉȍ~ALrLłɂ钆ł͋NĂȂB
3 ŏǏ LrLłɂ钆ŏǏ͐H㐔ԈȓɓfCAqfAɁAɁANAdǂ̊҂ł͋LrAAtȏrA 񂪂݂Aɂ莀Sꍇ[3]B
4 Ő
i1ĵщw\ hEC_

}1@hEC_̍\
i2jwI hEC_͕q3‚̃J{LVŽ_C~m_ŐɈ՗nA_ł̓J{LV̉𗣂}ꐅւ nxቺAsłB
i3jŐ hEC_̃}EXɑ΂LD50ĺAo^4 mg/kgł[4]B}EX(̏d20 g)ɃhEC_50 g𕠍o^ƁA ㎈ŕނȂ炮邮ƉXNb`Vh[Ƃ΂IȓB
i4jŗ Ji_̒Ŏł́Ayǎ҂ł̓hEC_60`110 mgAdǎ҂ł115`290 mgɂB[3]B
i5jp@\ hEC_͒_o`BL-O^~_̃ASjXgƂčpāA_oזẼCI`l^O^~_êɌB hEC_]ɐNꍇACnAAG̍זE󎀂[5]B
i6j͕@ hEC_̌Aʂ́uHiqwjAwҁv[6]ɎQl@ƂHPLC-UV@LڂĂB 𒊏on}i^m[F1F1jŒoASASO߂AꂽtHPLC͂ɋA242 nmɂzxŌoA ʂBhEC_͂̕ɂLC/MS܂LC/MS/MS@[7]A@ƂĂELISA@[8, 9]JĂB
i7jQl 킪ł́ALrLŁihEC_jɑ΂Ď̐Kl͒߂ĂȂAAoꍇɂ͊ŐKli20 ppmjpB
5 ő΍ ʼnLނ̌ɂ߂͊O͂łAʓIȒMł͓őf͕ȂB_ł͗LȒő΍@͂ȂB
6
  1. Jeffery B, Barlow T., Moizer K, Paul S, Boyle C: Amnesic shellfish poison. Food Chem Toxicol, 42, 545-557 (2004).
  2. Costa P R., Rosa R, Duarte-Silva A, Brotas V, Sampayo M A M: Accumulation, transformation and tissue distribution of domoic acid, the amnesic shellfish poisoning toxin, in the common cuttlefish, Sepia officinalis. Aqua Toxicol, 74, 82-91 (2005).
  3. Todd ECD: Domoic acid and amnesic shellfish poisoning-A review. J. Food Protec, 56, 69-83 (1993).
  4. Grimmelt B, Nijjar MS, Brown J, Macnair N, Wanger S, Johnson GR, Ahmend JF: Relationship between domoic acid levels in the blue mussel (Mytilus edulis) and toxicity in mice. Toxicon, 28, 501-508 (1990).
  5. Pulido OM: Domoic acid toxicological pathology: A review. Mar Drugs, 6, 349-371 (2008).
  6. JȊďCFHiqwj w, {Hiq,pp.666-673 (2005).
  7. Wang Z, King KL, Ramsdell JS, Doucette GJ: Determination of domoic acid in seawater and phytoplankton by liquid chromatography- tandem mass spectrometry. J Chromatogr A, 1163, 169-176 (2007).
  8. Kawatsu K, Hamano Y, Noguchi T: Production and characterization of a monoclonal antibody against domoic acid and its application to enzyme immunoassay. Toxicon, 37, 1579-1589 (1999).
  9. Klevdai H, Kristiansen SI, Nilsen MV, Brigga L: Single-laboratory validation of the biosense direct competitive enzyme-linked immunosorbent assay (ELISA) for determination of domoic acid toxin in shellfish. J AOAC Intl, 90, 1000-1010 (2007).
7 Ql}
  • ʗY, ŽqFLł̓ \ḦSƈS\. RX (2004).
  • Y, TFV Cm̓. RX (2006).

z[ > ɂ‚ > ʂ̐ꗗ > NE > Hi > H > Rł̃XNvt@C > Rł̃XNvt@CF񖇊LFLrL

y[W̐擪֖߂