| 1 |
LŎ |
ƂătOȋނtOłAtOŒł̌HiƂȂBŗ͂̋̓tO̎ނƕʂɂđ傫قȂ̂ŁA킪ł͐Hp\ȃtO̎ނƕʂ߂ĂiwɂľNꂪȂƔF߂tO̎ނѕʁx˃NbNjBgtOɂ͎RŎG킪݂̂ŁAS̎G܂ގޕstO̔ i˃NbNjmFAޕstO◼e킪ӕʂłȂGtÓAmɔr邱ƁBtO̓AƂɊ̑◑ɂ͍Zx̓őf~ςĂ̂ŁAHׂꍇɃtOŒłɂȂ邱ƂB{݂ł݂tOȋނ̓ŗ͂ƐHp̓Kۂ͈ȉ̃XgNbNĊmFꂽB
{݂ł݂tOȋ
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킪ł͔NԂɖ30̃tOŒłAҐ͖50ŐSĂBtOŒł͒ނlflɂƒ뗿ɂȂ邱ƂB
@HŔ͂B [16KB]
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| 3 |
ŏǏ |
tOłɂ钆ŏǏ͐H203Ԓx̒ZԂŌBdǂ̏ꍇɂ͌ċzŎS邱ƂBŏǏ͗ՏI4iKɕB
1iKF Oѐ[ɌyჂꂪAwჂꂪNAs͂ڂȂȂBɂ╠ɂƂB
QiKF sS^ჂNAqf܂Ȃ^s\ɂȂAmoჁAQɂȂBċz悤ɂȂA~NB
RiKF Sg̊SჂAi͒oɂA͂ł邪tɂȂȂBቺAċzƂȂB
SiKF ӎ݂ċz~Bċz~S͂炭𑱂邪A₪Ē~SB
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Ő |
| i1ĵщw\ |
eghgLVB
eghgLVѓ̂̍\}1ɎB
| |
R1 |
R2 |
R3 |
R4 |
| eghgLV |
H |
OH |
OH |
CH2OH |
| 4-GseghgLV |
OH |
H |
OH |
CH2OH |
| 6-GseghgLV |
H |
OH |
CH2OH |
OH |
| 11-fILVeghgLV |
H |
OH |
OH |
CH3 |
| 11-meghgLV-6(R)-I[ |
H |
OH |
H |
OH |
| 11-meghgLV-6(S)-I[ |
H |
OH |
OH |
H |
| 11-meghgLV-6,6-WI[ |
H |
OH |
OH |
OH |
| 11-IL\eghgLV |
H |
OH |
OH |
CH(OH)2 |
}1@eghgLVѓ̂̍\
eghgLVѓ̂̍\≻wIɂĂ͉Ĺuv[1]ɏڂB
|
| i2jwI |
eghgLV̌͗L@n}␅ɕsnAܐAR[_ntɂ͉nłB_ntł͉MɑĈ肾Antł̉MAJ⋭_ntł͕słBʓIȒMł͕ȂB |
| i3jŐ |
eghgLṼ}EXɑLD50ĺAÖ^8.7 g/kgAo^10 g/kgłB[2] |
| i4jŗ |
qg̒vʂ̓eghgLVɊZ1`2 mgƐ肳B[3] |
| i5jp@\ |
eghgLV͍i_o̖dʈˑigECI`lɌA`lւ̃igECI̗jQĐ_o`BՒf_ołłBeghgLV̖pɂĂ͉Ĺuv[4-7]ɏڂB |
| i6j͕@ |
tOł̌Aʂ́uHiqwjAwҁv[8]ɎĂBtOgD|_ʼnMot}EXɕo^A}EX̒vԂ}EXPjbgɊZēŗʂ𑪒肷@A{ł͌@ɏ́iQl@jƂȂĂBtOł̏ꍇȀd20g̃}EX30ԂŎSŗʂ1}EXjbgiMUjƒ`@A{ł͌@ɏ́iQl@jƂȂĂBgD1g10}EXjbĝ͐HpsKƔfBŐ͂̕ɂHPLC-uo@[9]LC-MS[10-12]܂LC-MS/MS[10, 13]ėpB |
| 5 |
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Hp\ȃtÓAʕ\wɂľNꂪȂƔF߂tO̎ނѕʁx(˃NbN)ŋꂽނ̃tÓA߂ꂽʂ݂̂łALŕʂ͏ĂȂȂȂB
tO̗Lŕʂ̏́As{mF߂ҋyю{݂ɌĎ舵ƂƂĂB
tO͋ɂĐHp\ȕʂقȂAnɂĂ͖̂قȂ邱ƂAނl̑flfɂ钲͐ɍsȂƁBtOŒłɑLȎÖ@ō܂͍̂ƂȂAlHċzɂċzmۂKȏu{ΊmɉłB |
| 6 |
|
- Yotsu-Yamashita M: Chemistry of puffer fish toxin. J Toxicol.-Toxin Reviews, 20, 51-66i2001j.
- Cao CY, Furman FA: Differentiation of the actions of tetrodotoxin and saxitoxin. Toxicon, 5, 25-34 (1967).
- Noguchi T, Ebesu JSM: Puffer poisoning: epidemiology and treatment. J Toxicol-Toxin Reviews, 20, 1-10 (2001).
- Geffeney S, Ruben P: The structure basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels. Mar Drugs, 4, 143-156i2006j.
- Fozzard H, Lipkind GM: The tetrodotoxin binding site is within the outer vestibule of the sodium channel. Mar Drugs, 8, 219-234 i2010j.
- Kamimura J, Zheng T, Uryu N, Ogata N: Regulation of the spontaneous augmentation of Nav1.9 in mouse dorsal root ganglion neurons: effect of PKA and PKC pathways. Mar Drugs, 8, 728-740i2010j.
- Zimmer T: Effect of tetrodotoxin on the mammalian cardiovascular system. Mar Drugs, 8, 741-762i2010j.
- JȊďCFHiqwj w, {Hiqi2005j.
- Nagashima Y, Maruyama J, Noguchi T, Hashimoto K: Analysis of paralytic shellfish poison and tetrodotoxin by ion-pairing high performance liquid chromatography. Nippon Suisan Gakkaishi, 53, 819-823i1987j.
- Shoji Y, Yotsu-Yamashita M, Miyazawa T, Yasumoto T: Electrospray ionization mass spectrometry of tetrodotoxin and its analogs: liquid chromatography/mass spectrometry, tandem mass spectrometry, and liquid chromatography/tandem mass spectrometry. Anal Biochem 290, 10-17i2001j.
- x], Έ䗢}, i, VTVFLC/MSɂtOŃeghgLV̕. Hq, 43, 234-238i2002j.
- Jang J-H, Lee J-S, Yotsu-Yamashita M: LC/MS analysis of tetrodotoxin and its deoxy analogs in the marine puffer fish Fugu niphobles from the southern coast of Korea, and in the brackishwater puffer fish Tetraodon nigroviridis and Tetraodon biocellatus from Southeast Asia. Mar Drugs, 8, 1049-1508i2010j.
- Ԗ؍_, aLFLC/MS/MSɂtOgDуqgEÃeghgLV̕. Hq, 47, 46-50i2006j.
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| 7 |
Ql}A |
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- ȐqǓqەҁF{ߊCYtO̊ӕʂƓŐ, @Ko (1994).
- ʗY, @, {vFLŋތgѐ}, Ώ[i1997j
- Y, TFV Cm̓. RXi2006j.
- {HiqF2 Hŗ\hKg. {Hiqi2007j.
- Noguchi T. iEd.j: Special issue on tetrodotoxin. J Toxicol- Toxin Reviews, 20, 1-84 i2001j.
- Noguchi T, Arakawa O, Takatani T: TTX accumulation in pufferfish. Comp Biochem Physiol D, 1, 145-152 i2006j.
- Noguchi T, Arakawa O: Tetrodotoxin - distribution and accumulation in aquatic organisms, and cases of human intoxication. Mar. Drugs, 8, 220-242 i2008j.
- Williams B: Behavioral and chemical ecology of marine organism with respect of tetrodotoxin. Mar Drugs, 8, 381-398 i2010j.
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