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E^̉ECX̊Ed^̉p`

Hd^̉ECXɂ‚

id^̉p`j


@䂪ł2003NS̕Ɍɂ쐶VJ̐HƂd^̉ECXHŎႪA̐Hi̐ېHƂd^}̉ǂƂ̊Ԃ̒ړIȈʊ֌WmFŏ̎ƂȂ܂B܂ApȊwuJournal of General Virologyv2003NXfڂ̕񍐂ł́AkCŎŝĂ؃o[̈ꕔd^̉ECẌ`qoAMs\ȓ؃o[lւ̊̉”\Ă܂BɁA2005N3ɕŖ쐶CmVViH111Ad^̉𔭏ǂAECX`qŃCmVVƂ̈ʊ֌WmFꂽ񍐂Ă܂B
@JȂł͂̎𓥂܂Ad^̉\hɊւ񋟂ړIƂāÂƂd^̉Ɋւp`쐬܂B
@Ad^̉Ɋւm̐iWɑΉāAA{p`XVĂƂƂĂ܂B

@ȂA؃o[܂ޓؓтɃVJyуCmVVȂǂ̖쐶̓SɋiHׂ̒ӓ_ɂ‚āALɂƂ܂Ƃ߂܂̂łQlƂĂ܂悤肢܂B
E ؃o[܂ޓؓтɃVJyуCmVVȂǂ̖쐶̓i܂ށBj͐ŐHׂȂ悤ɂ܂傤B
E ؓтɃVJyуCmVVȂǂ̖쐶̓͒S܂ʼn΂ʂ悤A\ɉMĐHׂ܂傤B̂悤ȉM͂قƂǂ̊댯Ȕł邱ƂmFĂ܂B܂A̓̓ɂ‚ẮA҂⍂҂ȂǒR͂̎ア͐̐ێT悤ɂ܂傤B
E Msނ͐ĂɂȂȂ悤S܂ŏ\ɉ΂ʂ悤A\ɉMĂB
E ̓ނƉMς݂̓ނ͕Ď舵܂傤B舵MʂĎgpĂB


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pP @d^̉Ƃ͂ǂ̂悤ȕaCłH
pQ @ǂ̂悤ȏǏłH
pR @ǂ̂悤ɂĊ̂łH
pS @ff@́H
pT @Õ@́H
pU @\h@́H
pV @ۓIȔ󋵂́H
pW @{ł̔󋵂́H
pX @HiʂĊ͂ǂ̂悤Ȃ̂񍐂Ă܂H
pPO @ǂ̂悤ȓHEVmFĂ܂H
pPP @ŝ̓؃o[HEV̈`qoAd^̉ҔƂ̊֘Ả”\铙̕񍐂ĂƂ̂ƂłAǂ̂悤ȕ񍐂łH
pPQ @؂猟oECXɂ͂ǂ̂悤ȓ܂H
pPR @؃o[n߂ƂؗR̐Hi͈SłH
pPS @2003NWɕ񍐂ꂽ쐶̃VJ̎hgHׂĂd^̉𔭏ǂ́AVJ̎hg̐ېHڂ̌ɂȂ̂łH
pPT @{ł̓VJ͐HpƂėʂĂ̂łH
pPU @VJCmVVȂǖ쐶̓𐶂ŐHׂĂSłH
pPV @VJCmVVA؈ȊO̐H͐SzȂ̂łH


pP @d^̉Ƃ͂ǂ̂悤ȕaCłH

` @d^̉́Ad^̉ECXihepatitis E virusAȉuHEVvƂBj̊ɂĈN}̉iHɌNJ̉jŁA邱Ƃ͂܂BHEV͎ƂČo܂AHɁAɃECXǂĂ銳ҁi邢͕sҁǰtĊ邱Ƃ܂Bd^̉͊Jr㍑ɏ݂UIɔĂ鎾łAƂĉꂽȂǂK͂ȗsNꍇ邱ƂmĂ܂BAiɂẮAJr㍑ւ̗s҂̊ႪƂAuAǁvƂĔFė܂AߔNAnq̂ȂuǗvU悤ɂȂAÂ悤ȗႩ̎悳ꂽHEV́Aꂼ̒nɓĹuyvł邱Ƃ炩ɂȂė܂BREɂ銴̃TCN͖słA؂VJACmVVȂǂ̓qgHEVɍECXoĂ邱ƂAqgւ̊̕񍐂Ă邱ƂAł͖{͐lbʊǂƂđĂ܂B


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E lł͐tsS𔺂ƂB
E lꍇAsŏI邱Ƃ͏ȂAdlj邱ƂB
E ʂɐl߂HBVɊꍇ͈ߐ̊BAlłLAP[Xŋߕ񍐂ĂB
E }̉𔭏ǂꍇƔǂȂꍇisjƂB
E ɏIƉuB
E HBeRz̕e琶܂ꂽł́A\hɕuƍi80ȏjɃLAB
E cɊꍇɂLA邱ƂB
E HBVLÄꕔ͖̎ỉA̍dρÂj𔭏ǂB
E 킪ɂ͖̎҂܂߂āA100l150lHBVLAÂقƂǂ͌Ȃ΂킩ȂioǏ󂪂Ȃjnj󐫂̃LAł邱ƂmĂB
E l߂HCVɊꍇÂقƂǂ́AoǏ󂪂Ȃ܂܌o߂isjA30͈ߐ̊ŎA70̓LA邱ƂmĂB
E HCVLA̕e琶܂ꂽHCVɊăLA闦2`3xɎ~܂B
E HCVLAł́AHBVLAɔ䂵Ė̎ỉA̍dρÂj𔭕a闦B
E b^̎҂āA킪ɂ150lOHCVLA݂邱ƂmĂB
E ‚ăf^ij̉ƌĂ΂ẮB
E HDV́AHBVɊĂlɂ̂݊iHBVwp[ECXƂjsSECXłB
E 킪ɂHDV͏ȂB
E ߐ̊B
E LA邱Ƃ͂ȂB
E IƉu邩ۂ͕sB
E }̉𔭏ǂꍇ͂`^̉ɗގB
E HɌlj邱ƂB
E DwHEVɊĔǂꍇɂ́Alj闦ƌĂB
E lbʊǂƔFĂB̊̉ECXłB
LA̗L L L
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E wIFyAɂg`uR̉̏㏸AIgM HAVR̂̌o
E j_im`sjF HAV RNǍo
E wIF HBsŘoiyAɂgaR̉𕹗p邱Ƃ]܂jAyAɂHBcR̉̏㏸AHBcR̉̑iHBVLAƂ̊ӕʁjAIgM HBcR̂̌o
E j_F HBV DNǍo
E wIF HCVR̂̌oAHCVRAŘo
E j_F HCV RNǍo
E wIFHDVR̂̌oA̓HDVRif^Rǰo
E j_F HDV RNǍo
E wIFyAɂHEVR̉̏㏸AIgM HEVR̂̌o
E j_F HEV RNǍo
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pQ @ǂ̂悤ȏǏłH

` @HEVɊꍇAsƂĂ܂iɎNҁjB̉𔭏ǂꍇ̗ՏǏ͂`^̉ɗގAɉt𔺂܂BςUTԂ̐̌ɁiHɐ̌ӊA H~sȔǏ󂪐s邱Ƃ܂jAMASEɓ̏ǏA̎A̋@\̈igXA~i[[㏸EtjA唼̏Ǘł͈É珰ixbh̏œɈÂۂ‚Ɓjɂ莡܂A܂ɌljP[X܂B
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pR @ǂ̂悤ɂĊ̂łH

` @oH͌ołAHEVɉꂽHA̐ێɂ芴邱ƂƂĂ܂Bqgqgւ̊ɂ‚ẮA݂Ȃǂɂ򖗂ڐGɂ銴͕񍐂Ă܂񂪁AAɂ銴Ⴊ񍐂Ă܂B

pS @ff@́H

` @wIł́AIgMŔAIg`R̂̌oɂĐff܂i܂ɋ[z[A݂܂jB
@mȐff@ƂẮAj_iNATART-PCRjɂHEV RNǍo܂B

pT @Õ@́H

` @d^̉̎Õ@́Â݂Ƃ}̑ΏǗÖ@܂Bljꍇɂ́AɌAlH̕⏕Ö@ÄڐAȂǂ̓ꎡÂKvƂȂ܂B

pU @\h@́H

` @HAVyHEV̊oH͌ołAECXɉꂽHA̐ێɂ芴邱Ƃ̂ŁA\hɂ͎􂢁AH̉MdvłB
@d^̉sn֗sۂ́A̕ۏ؂ȂiX萴܂ށjAM̊LށAgŔނȂ񒲗̉ʕE؂ƂȂ悤ɒӂKv܂B
@̓Aɓ؃o[Hׂۂɂ́AS܂ʼn΂ʂ悤\ɉM邱ƂdvłBHׂO̒̒iKłA畆̏ECX̓֓邱Ƃ̂Ȃ悤ӂĂipPRAPUyтPVQƁjB
@ȂAN`͊JiKłB

pV @ۓIȔ󋵂́H

` @d^̉́AAWAł̗s͏HɌAAWAł͉JɁAɍL͂ɍ^NɔƂĂ܂B
@d^͕̉oHɂē`dAłnɂ嗬s܂łɕ񍐂Ă܂B1955NAj[f[ŋ}̉̑嗬s܂A͕ւɂĉꂽp㐅ʂ̊ƂȂĂ܂B̗sł͉t̉ƐffꂽǗႾł29,000lɋył܂BɎnɂ嗬sAWAAAkAtJALVRȂǂł񍐂Ă܂BߔNɂĂ̂悤ȑK͂ȗs΂Ε񍐂A1991NAWl߂Wc񍐂ꂽCh̗ł̉łB1986`1991Nɂ͒̐VECOłSɂ킽đK͂Ȃd^̗̉s݂Ă܂BN̒nł́AHGHEV҂}ɑXɂƂĂ܂B
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pW @{ł̔󋵂́H

` @{ł́Ad^̉fftɑ΂ẮAǂ̗\hyъǂ̊҂ɑ΂ÂɊւ@iȉAuǖ@vƂBjɊÂAیɒɓ͏o邱Ƃ`ÂĂ܂iE^̉́ulފǁvɕށjB͏o󂯂ی́As{ʂJȂɕ񍐂ƂƂɁAǖ@yѐHiq@̋KɊÂA⊴A{ݓɂ‚Ēs܂Bt̓͏oWvǔɂƁA1999NSȍ~E^̉ƕ񍐂AHEVmFꂽ҂́A1999N0A2000N3A2001N0A2002N16A2003N30A2004N37A2005Ni1`8j32Av118ŁAł̊肳銳҂̕񍐂2002Nȍ~}Ă܂BAOŊƐ肳銳҂̕񍐂2003Nȍ~Ă܂B񍐐̑́Aŋ߁ART-PCR@ɂHEV`qoyELISA@ɂIgMŘoł̊mff”\ƂȂƂ𔽉fĂƍl܂BGߐ͖炩ł͂܂Bff܂łɗv݂ƁAf10ȓɂŜPA19ȓ2̂PA28ȓ43̊҂ffĂA̓vĂ܂iaoVol.26 p 261-262d^̉@2005NW݁jB
@j101i71AO28AsQjA17i15AOQjƁAAOƂ|IɒĵłB͒j50㔼A60㔼s[NɁAƂɒN̂ɑ΂AO20`30O悤łiaoVol.26 p 261-262d^̉@2005NW݁jB
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@܂A1993Nɍ̌ꂽ{̌ľɂHEV Rۗ̕L5.4(49/900)ŁA20ȉł͔ɒႭ(0.4)A30(6.2)A40(16)A50(23)ƔNقǕۗLƂ񍐂Ă܂B
@ȂAOq̌ǂ̒ɂ΁AŜ31%RiHRjłƐ肳AA7.9%AÅmႪ2.3%݂ƂĂ܂A58%̏Ǘ́uoHsvłƕ񍐂Ă܂ȋ@478@384-391i2006jjB

pX @HiʂĊ͂ǂ̂悤Ȃ̂񍐂Ă܂H

` @]AłOłA̐Hi̐ېHƂd^̉̔ǂƂ̊֌WړIɊmFꂽ̕񍐂͂܂łB
@A2003NSɕɌŗⓀVJiHQƑVSǂA}̌HEV-IgMR̋yHEV`qoAⓀVJci猟oꂽHEü`qz񂪊҂猟oꂽHEu`q̂̂ƂقڈvƂ񍐂AꂪHi̐ېHE^̉̔ǂƂ̒ړIȊ֌WmFꂽE̎ɂȂ܂(Lancet@2003; 362: 371-3)BXɂ́A2005NRɕŖ쐶CmVViHPPPǂACmVVciHEuoAҌ猟oꂽHEV̈`qzƈv܂iEmerging Infectious Diseases 2005; 11: 1958-60jB

pPO @ǂ̂悤ȓHEVmFĂ܂

` @ߔNAiɂHEVݒnւ̓nq̂Ȃ}̉҂HEVoAHEV̈`qYn̓؂̎悳HEV̈`qƋɂ߂ėގĂ邱ƂȂǁA{lbʊǂł”\Ă܂B
@܂Ae̓HEVɊ󐫂̂邱ƂA{̓؂ɂ‚čsꂽł͐60̓73QƐ90̓22P̌HEV`qoꂽAP`U̓؂̕ւgdu`qoĂ܂B܂ARP_̌ɂ‚čŘ{ƂARO_̓؂ōR̗złBR̗z_ł͂S|TłPOO̓؂R̂ۗLAECXoiRT-PCRjł́AQ|Rׂ̂Ă̓؂猟oꂽƂ̕񍐂܂i15NxJȊwʌƁuHiɗRE^̉ECX̃XN]Ɋւ錤vjB
@쐶CmVVɂĂAn̍͂̂́A10-50̌‘̂IgGR̗złA5-10̌‘̂̌tȂHEV`qoĂ܂BOq̂悤ɁACmVVqgւ̊ؖĂ܂ipX)B
@킪̖쐶VJɂẮAR̂Œ‘̂͋ɂ߂ďłAHEṼU[o[Ƃ͍lɂ̂łAVJqgւ̒ړ`d񍐂Ă̂ŒӂKvłB
@܂A1997NɁAqgHEVƓHEV؂ɂ݂邱Ƃ߂ĕ񍐂ĈȗA܂łɁAVJACmVVAE}AbgA}O[XHEV`qoȂɂARrAlRȂǑ퓮HEVŘo̕񍐂AmFg݂i߂Ă܂B

pPP @ŝ̓؃o[gdü`qoAd^̉ҔƂ̊֘Ả”\铙̕񍐂ĂƂ̂ƂłAǂ̂悤ȕ񍐂łH

` @2003NXsJournal of General Virologył́AkC̐HiXŎŝĂς݂̓ؐo[363Vi1.9jHEV`qoÂЂƂ‚͖kCݏZ86΂̊҂番ꂽHEVƈ`qz100vƂ񍐂܂Bɂd^̉Ɋ҂POl̂Xli90jAǑÔQ`WT̊ԂɏĂ͉Ms\ȓ؃o[̋iHLĂ܂B̕񍐂ł́AȑO؃o[HĂ銳҂Ȃ񊴐̂AY؃o[ɂ͊͂d^ECX݂̂ȂǁA𖾂ׂ^͂̂́AMs\ȓ؃o[lHEV”\wEĂ܂B
@ȂA̓؃o[Hׂ҉Ƒ̕蒲HEVŘɂA\ɉMĐېHƑł͊ȂƂĂ܂B
@2004N11ɂ́AkCɂ1̂d^̉҂A҂ƓHX𗘗p҂̂6HEVɊĂƂmFꂽႪAƂĈHXœ؃o[̓ؓR̐Hi\ɉMȂŋiH”\Ƃ񍐂܂ȋ@4512@688-688i2004jjBkC̒̌ʁAʂ̈HXŋiHO[v犴҂mF܂AyъoH̓ɂ͎܂łB
@܂A2006N23ɂāAkCE^̉𔭏ǂ4ɂ‚āAt猟oꂽHEV̈`qz񂪂vƂ񍐎Ⴊ܂BkCyюDys̒̌ʂɂƁA4̊҂͂ꂼꔭǑOɓ؂̓HׂƂ͊mFĂ܂AoH̓ɂ͎炸ʂ̊邩ǂ͕słB

pPQ @؂猟ogduɂ͂ǂ̂悤ȓ܂H

` @܂ł̌ʂ́A؂͂̈琬HEVɍɊ܂ipPOQƁjA؂ʏoׂǓtHEVĂ܂BAꕔ̌‘̂ł͂UɂĂւƊ̑HEVȂcĂAƂ̕񍐂Ă܂i15NxJȊwƁu{Mɉd^̉̐ffE\hEuwɊւ錤vjB

pPR @؃o[n߂ƂؗR̐Hi͈SłH

` @؃o[͂߂Ƃؓɂ‚ẮAŐHׂȂ悤ɂ܂傤B܂AM̍ۂɂ͒S܂ʼn΂ʂ悤\ɉMĂB؃o[ȂǂɖECXcĂƂĂA\ɉMsHEV͊߁A؃o[Ȃǂ̓ؗRHiHׂ邱Ƃɂ銴̊댯͂܂BnE\[Z[W̉MςݐHiɂ‚ĂAHEV́AYHỉHɍs6330ԂƓȏ̔MŊ߁ASz͂܂B

pPS @2003NWɕ񍐂ꂽ쐶̃VJ̎hgHׂĂd^̉𔭏ǂ́AVJ̎hg̐ېHڂ̌ɂȂ̂łH

` @{́ÃVJ𐶂ŐHׂSU`VTԌɂd^̉𔭏ǂA҂猟oꂽHEVƈꕔۑĂVJ猟oꂽHEV̈`qz񂪈vƁAYVJSHׂĂȂA͂ʂHׂȂ҉ƑHEVɊȂƂmFA̐Hi̐ېHƂd^}̉ǂƂ̒ړIȊ֌WmFꂽŏ̎ƂĂ܂B

pPT @{ł̓VJ͐HpƂėʂĂ̂łH

` @{ɐ쐶̃VJ́A‚LQb쏜ɂđSŔNԖPOߊlĂ܂BߊlꂽVJ͐HƎ҂ɂĉ̏AHƂėʂĂ܂BN300`400g̏ƌĂAY200`300głƐ肳܂B

pPU @VJCmVVȂǖ쐶̓𐶂ŐHׂĂSłH

` @VJCmVVȂǖ쐶̓͐ŐHׂȂ悤ɂ܂傤B
@HEV͔Dw⍂ҁAHBV邢HCV̎҂ɊƌNJ̉𔭏ǂAS闦Ƃʂ邱ƂADwyэ҂͓ɖ쐶̓𐶂ŐHׂ邱ƂׂłB
@쐶lbʊǂHł̌ƂȂaA񐶒ޓۗLÔ\́AɔOɂKv܂BߋɂA쐶̓̐H͒Ǐo咰ۊǂgqiNjyєxzǓ̌ƂȂĂ܂B̕â͈ʂɒʏ̉MɂĎł邱ƂmĂ邱ƂA쐶̓Hׂۂɂ͒S܂ʼn΂ʂ悤\ɉMsƂɂ芴\h邱Ƃł܂B
@ȂA2003Nɕ񍐂ꂽ́AVJ猟oꂽHEV̔Zx߁ẢߒŊ̑牘ꂽ̂ł͂ȂAVJɎc錌tɊ܂܂ĂHEVƂȂ”\ƍl܂B

pPV @VJCmVVA؈ȊO̐H͐SzȂ̂łH

` @߂rARrHEVR̂oƂ̕񍐂܂AMsƂɂHEV͊߁AS܂ʼn΂ʂ悤\ɉMΐHɂ銴̊댯͂܂B
@ȂAJȂł͒Ǐo咰ېHŗ\h̊ϓ_ҁA҂̂قR͂̎ア҂ɂ‚ẮAHׂȂ悤]璍ӊNsĂ܂B


QlN
@ njǏZ^[
aoijFIASR
http://idsc.nih.go.jp/iasr/23/273/dj2733.html
ǔTFIDWR ǂ̘b
http://idsc.nih.go.jp/idwr/kansen/index.html
WHO@Hepatitis E
http://www.who.int/mediacentre/factsheets/fs280/en/i2012N7XVj
č@CDC
http://www.cdc.gov/ncidod/diseases/hepatitis/index.htm
J
https://www.mhlw.go.jp/topics/0105/tp0502-1.html


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gV@_i @搶iLww@j

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