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(3) Hĩ_CILVނ̐v@Ɋւ錤
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(4) _CILVނ̃XNጸɊւ錤
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n n ֐n ln Bn
b ֐` ֐a ֐b l` lB lb B` Ba
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13Nx PDTR | PDRR QDOO | ODWW PDUO RDSO |
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(pgTEQ/)		 100.3
(61.3`138.4)		 112.6
(59.5`350.7)		 72.66
(42.1`100.5)		 81.47
(33.3`169.9)
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(pgTEQ/kgbw/)		 2.01
(1.22` 2.77)		 2.25
(1.19` 7.01)		 1.45
(0.84` 2.01)		 1.63
(0.67` 3.40)
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Hi Yn _CILVށipgTEQ/g)
PCDDs+PCDFs Co-PCB Total

̉Hi
iFHij		 A 0.001 0.001 0.001
A 0.010 0.001 0.010
Ȃij Y 0.190 0.466 0.656
Ȃij Y 0.011 0.205 0.216
Ȃigj Y 0.916 1.692 2.608
Ȃ Y 0.143 0.162 0.305
Ȃ Y 0.383 0.359 0.742
Ȃ Y 0.160 0.616 0.776
킵 Y 0.389 0.534 0.923
킵 Y 0.431 0.887 1.318
킵 Y 0.393 0.413 0.806
Y 1.407 0.994 2.401
Y 0.014 0.047 0.061
Ƃ Y 0.007 0.061 0.068
Ƃ Y 0.009 0.059 0.068
A 0.041 0.037 0.078
Ԃ@ Y 0.206 0.510 0.716
Ԃ Y 0.307 1.038 1.344
ɂ܂ Y 0.070 0.507 0.577
ɂ܂ Y 0.462 0.813 1.276
܂ A 0.005 0.021 0.026
܂@@@@ A 0.005 0.129 0.134
܂@@ A 0.170 0.751 0.921
킩 Y 0.162 0.221 0.383
킩 Y 0.047 0.092 0.139
ڑJ Y 0.001 0.025 0.025
ڑJ Y 0.094 0.373 0.466
ڑJ Y 0.330 0.520 0.850
΁ A 0.214 0.834 1.048
΁ A 0.277 0.882 1.159
A 0.047 0.112 0.159
A 1.861 4.235 6.096
܂ڂ Y 0.001 0.001 0.001
܂ڂ Y 0.001 0.001 0.001
Y 0.237 0.192 0.429
炷igj Y 0.264 0.332 0.596
炷igj Y 0.072 0.132 0.204
炷ij Y 0.092 0.583 0.675
߁ Y 0.022 0.012 0.034
߁ Y 0.269 0.386 0.655
قJ Y 0.167 0.253 0.420
قJ Y 0.543 0.955 1.498
߂ Y 1.052 1.303 2.355
߂ Y 1.083 2.435 3.518
ԊLtʋl Y 0.026 0.022 0.048
ԊLtʋl Y 0.450 0.160 0.610
킵tʋl Y 0.005 0.019 0.024
킵tʋl Y 0.308 0.446 0.754
킵ØIρ Y 0.282 0.411 0.694
킵ØIρ Y 0.237 0.383 0.620
{YHi ^ Y 0.197 0.073 0.269
H Y 0.006 0.053 0.059
H Y 0.025 0.081 0.106
H Y 0.035 0.025 0.060
n Y 1.230 0.555 1.785
Rr[t A 0.044 0.026 0.070
T~ A 0.039 0.018 0.057
T~ A 0.001 0.024 0.024
{Xn Y 0.001 0.001 0.001
{Xn Y 0.005 0.001 0.006
{ Y 0.072 0.090 0.162
{ Y 0.024 0.040 0.064
i }[K Y 0.005 0.001 0.006
}[K Y 0.003 0.001 0.003
}[K Y 0.003 0.001 0.003
[Og Y 0.020 0.011 0.031
[Og Y 0.005 0.001 0.006
[Og Y 0.021 0.011 0.032
ށC Y 0.001 0.001 0.001
Y 0.001 0.001 0.001
Y 0.001 0.001 0.001
Y 0.001 0.001 0.001
؁Cʎ Lxc Y 0.001 0.001 0.001
Lxc Y 0.001 0.001 0.001
߂ Y 0.001 0.001 0.001
̂ A 0.001 0.001 0.001
ubR[ A 0.001 0.001 0.001
ubR[ A 0.001 0.001 0.001
ubR[ A 0.001 0.001 0.001
R Y 0.001 0.001 0.001
Y 0.001 0.001 0.001
LECt[c A 0.001 0.001 0.001

iEX܂ށj		 Y 0.001 0.001 0.001
Y 0.001 0.001 0.001
傤 Y 0.001 0.001 0.001
傤 Y 0.001 0.001 0.001
| Y 0.001 0.001 0.001
| Y 0.001 0.001 0.001
hbVO Y 0.001 0.001 0.001
hbVO Y 0.001 0.001 0.001
X Y 0.001 0.001 0.001
X Y 0.001 0.001 0.001
X Y 0.001 0.001 0.001
nD R[ Y 0.001 0.001 0.001
R[ Y 0.001 0.001 0.001
{ Y 0.001 0.001 0.001
{ Y 0.001 0.001 0.001
r[ Y 0.001 0.001 0.001
r[ Y 0.001 0.001 0.001
C A 0.001 0.001 0.001
C A 0.001 0.001 0.001
̑ A[h A 0.001 0.001 0.001
v[ij A 0.001 0.001 0.001
Cہij Y 0.188 0.001 0.190
ǂ Y 0.001 0.001 0.001
ǂ Y 0.001 0.001 0.001
rXPbg Y 0.001 0.001 0.001
R[q[ A 0.001 0.001 0.001
Е Y 0.001 0.001 0.001
Е Y 0.001 0.001 0.001
Е Y 0.001 0.001 0.001



\Q@PRNx@xr[t[h̃_CILVނ̔ZxipgTEQ/g)

Hi [J[ _CILVށipgTEQ/g)
PCDDs+PCDFs Co-PCB Total
CI A 0.001 0.001 0.001
CI B 0.001 0.001 0.001
B 0.001 0.001 0.001
CI B 0.001 0.001 0.001
CI C 0.001 0.001 0.001
CI D 0.001 0.001 0.001
ʎE
Hi		 R[X[v E 0.037 0.023 0.060
R[X[v D 0.001 0.001 0.001
؃X[v D 0.001 0.001 0.001
E 0.001 0.001 0.001
E 0.001 0.001 0.001
F 0.001 0.001 0.001
vioiij F 0.001 0.001 0.001
[Ogit[cj F 0.001 0.001 0.001
т i؁j F 0.001 0.001 0.001
͂i؁j G 0.001 0.001 0.001
iꂢC킩߁j F 0.001 0.001 0.001
i炷j F 0.001 0.001 0.001
hAigC`[Yj F 0.001 0.001 0.001
iC؁j F 0.001 0.001 0.001
`LCX F 0.001 0.001 0.001
݂͂iܖځj F 0.001 0.001 0.001
݂͂i{Cڂj F 0.003 0.001 0.004
`[ni炷j F 0.006 0.023 0.029
݂͂i{C؁j D 0.001 0.001 0.001
hAiC؁C`[Yj D 0.001 0.001 0.001
E 0.001 0.001 0.001
`[niؓC؁j D 0.001 0.001 0.001
͂iC؁j E 0.001 0.001 0.001
˗ ύ݂ǂi؁j G 0.001 0.001 0.001
ύ݂ǂ F 0.001 0.001 0.001
ύ݂ǂi{j F 0.001 0.001 0.001
ύ݂ǂi؁j D 0.001 0.001 0.001
ύ݂ǂ E 0.001 0.001 0.001
ύ݂ǂij F 0.001 0.001 0.001
J[EV`[ ؓJ[ F 0.001 0.001 0.001
ؓJ[ G 0.001 0.001 0.001
V`[iC؁j E 0.001 0.001 0.001
V`[ij D 0.001 0.001 0.001
V`[iЂ߁C؁j D 0.001 0.001 0.001
̑
íj		 ϕiꂢCj F 0.001 0.020 0.020
ϕi‚݂C؁j F 0.001 0.001 0.001
V`[iGrC؁j E 0.001 0.001 0.001
ϕiȁC؁j H 0.006 0.001 0.007
ϕigC؁j B 0.001 0.005 0.005
ϕi{Cj F 0.001 0.001 0.001
ϕiCܖځj E 0.001 0.001 0.001
ϕio[C؁j E 0.009 0.013 0.023
{[ F 0.001 0.001 0.001
rXPbg D 0.002 0.002 0.004
{[ D 0.006 0.012 0.018


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_CILV̉ԔcyѐێጸɊւ錤

Cҁ@@Lc@iHiq@Hi

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@_CILVނɂHiԂѐHoRێʂc邽߂̒{ƂƂɁC_CILVނ̐ێጸ}邱Ƃу_CILV̐vړIƂāCL4ۑ̌{D

i1-1j_CILVނ̃g[^_CGbg
i1-2jHiɂ_CILVނ̐v@JɊւ錤
iQj•ʐHĩ_CILVމԒ
iRjHĩ_CILVނ̃XNጸɊւ錤
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@(1-2)ł́CCALUXiChemically Activated Luciferase ExpressionjAbZCs̋_CILVޓŐʂ𐄑XN[jO@ƂēKLĂ邱Ƃ𖾂炩ɂD
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(1-1)_CILVނ̃g[^_CGbg
(1-2)Hiɂ_CILVނ̐v@JɊւ錤
(2)•ʐHĩ_CILVމԒ
(3)Hĩ_CILVނ̃XNጸɊւ錤

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S(1-1)
@S7n12@ւŁCꂼ120iڂ̐HiwCJȂ̕11Nxh{̐Hiʐێʕ\ɊÂāC̐HivʂĈ܂܂܂͒C13QɑʂāCψꉻ̂ƂDɑ14QƂĈƂDɂ‚āCuHĩ_CILVޑ@KChCv ɏ]ă_CILVނ𕪐͂CPێʂZoD

S(1-2)
@CALUX(Chemically Activated Luciferase Expression)AbZCiVtF[[`q𓱓|{זE𗘗p|[^[W[AbZCj́Cs̋̃_CILVޑւ̓Kp؂CœKŎs̋𑪒肵C]@łHRGC/HRNMSɂ鑪茋ʂƔrD

S(2)
@Cエѕō̎悵YHiCїAHiv111CтɎs̃xr[t[hi51ɂ‚āCuHĩ_CILVޑ@KChCvɏ]ă_CILVނ𕪐͂D

S(3)
@CALUXAbZCAhCmAbZCpāC_CILV(2,3,7,8-TCDD)ɂAhZv^[ɑ΂e̐AHio̗}ʂ𑪒肵D


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S(1-1)
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S(1-2)
@CALUXAbZC𗘗pCs̋̃_CILVޑ݂ʁC{@ɂs̋̃_CILVނxɑł邱ƂDCALUXAbZCɂ鑪茋ʂ͏]@łHRGC/HRMSɂ镪͌ʂƗǍDȑւCŐʂ𐄑XN[jO@ƂēKLĂDCALUXAbZC͏]@ɔׁCRXgC܂vɌʂĈɂp”\ȂƂCHĩ_CILVނ̃XN[jO@ƂĊ҂ł錋ʂłD

S(2)
@Nނ畽0.600 pgTEQ/g̃_CILVނoꂽCߋ2N̒ʂႢlłCΏۋ킪NxɂĈقȂ邱ƂCoNωƂƂ炦邱Ƃ͂łȂD@AHiCnD̃_CILVޔZx0.001 pgTEQ/ĝ̂DoꂽꍇHiɔׂĒႢlłD @s̃xr[t[hł́C_CILVޔZx0.001 pgTEQ/ĝ̂񔼐i27jłD0.010 pgTEQ/gȏ㌟oꂽ̂5łCōl0.060 pgTEQ/głDs̃xr[t[hɂ‚č񓾂ꂽl͈ʂ̖ؒ̃_CILVޔZxɋ߂D

S(3)
@n[ũZ[WCzEȂǂ̗Ηt؂ъkނ̒oC2,3,7,8,-TCDDɂAhZv^[ɑ΂ė}ʂDZ[W̓Rg[ƔrCALUXAbZC79AAhCmAbZC83̗}ʂC񋟎̒ōłʂČʂ͔ZxˑIłDCrgł̃f[^ł͂邪C‚̐AHiɂAhZv^[̊}t@N^[݂̑ꂽD


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i1-1jg[^_CGbgɂC_CILVނPێʂ̑Sς1.63 pgTEQ/kgbw/daył邱Ƃ𖾂炩ɂDڂ𒲍KvD

i1-2jCALUXAbZC̃_CILVޓŐʂ𐄑XN[jO@ƂėLpł邱Ƃ𖾂炩ɂDセ̑̃AbZC@ɂ‚ĂLp̌؂sD

i2jʐHiуxr[t[hĩ_CILVނ𕪐͂CԂ𖾂炩ɂDlx̃XN]s߂ɁC•ʐHi̓f[^̏Wς𑱂D

(3)Z[WCkށCzEȂǂ̒oC2,3,7,8-TCDDɂAhZv^[ɑ΂ė}ʂƂ𖾂炩ɂDセ̗L̖{̂ɂ‚Či߂D


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2) Amakura, Y., Tsutsumi, T., Nakamura, M., Fujino, J., Kitagawa, H., Sasaki, K., Yoshida, T., Toyoda, M: Preliminary screening of the inhibitory effect of food extracts on activation of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo- p-dioxin, Biol. Pharm. Bull., 25, 272-274 (2002).


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1) @q, VqǵC, 쏁q, kGq, Brown DJ, Clark GC, X؋vq, Lc. CALUXoCIAbZCɂs̋_CILVނ̃XN[jO@̊J.S‹zwi2001.12j

2) VqǵC@qCC쏁qCkGqCX؋vqCgcuCLcF_CILVɂAYfZv^[̊ɑ΂Hi̗}ʁC{w122Ni2002. 3jD

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