Tacrine-Natural-Product Hybrids for Alzheimer’s Disease Therapy | Bentham Science
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Review Article

他克林-天然产物杂交用于阿尔茨海默氏病治疗

卷 27, 期 26, 2020

页: [4392 - 4400] 页: 9

弟呕挨: 10.2174/0929867325666180403151725

价格: $65

Open Access Journals Promotions 2
摘要

阿尔茨海默氏病（AD）是一种复杂的神经退行性病变，其表现为高胆碱能和神经递质缺陷，氧化应激，炎症，导致衰老斑块形成的Aβ聚集以及tau蛋白的过度磷酸化，从而导致神经原纤维缠结。由于其多因素和复杂的性质，现在认为能够同时抑制或结合参与AD进展和发展的多种生物学靶标的多靶标定向小分子被认为是设计用于AD治疗的新化合物的最佳治疗策略。 其中，他克林是众所周知的标准金配体，天然产物已成为用于多种治疗方法的传统新剂的传统来源。 在这篇综述中，我们将更新用于AD治疗的多靶点tacrine天然产物杂种的最新进展。

关键词: 乙酰胆碱酯酶，阿尔茨海默氏病，抗氧化剂，丁酰胆碱酯酶，多靶标定向配体，天然产物，他克林。

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