Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models

Title: Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models

Volume: 7 Issue: 4

Author(s): Natalie O. Karpinich, Samantha L. Hoopes, Daniel O. Kechele, Patricia M. Lenhart and Kathleen M. Caron

Affiliation:

Keywords: Adrenomedullin, angiogenesis, endothelial, lymphangiogenesis, mouse model, permeability, CLR, RAMPs, G-protein coupled receptors, transmembrane accessory proteins, vasodilator

Abstract: Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.

Cite this article as:

O. Karpinich Natalie, L. Hoopes Samantha, O. Kechele Daniel, M. Lenhart Patricia and M. Caron Kathleen, Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models, Current Hypertension Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157340211799304761