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0 R 400 0 R 401 0 R 402 0 R 403 0 R 404 0 R 405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 411 0 R 412 0 R 413 0 R 414 0 R 415 0 R 416 0 R 417 0 R 418 0 R ] /P 257 0 R /Pg 1 0 R /S /P /Type /StructElem >> endobj 276 0 obj << /ActualText (Many major diseases, including various types of cancer, are increasingly threatening human health. ) /K [ 17 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 277 0 obj << /ActualText (However, the mechanisms of the dynamic processes underlying these diseases remain ambiguous. From ) /K [ 18 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 278 0 obj << /ActualText (the holistic perspective of ) /K [ 19 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 279 0 obj << /ActualText (systems science) /K [ 20 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 280 0 obj << /ActualText (, complex biolog) /K [ 21 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 281 0 obj << /ActualText (ical networks can reveal biological ) /K [ 22 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 282 0 obj << /ActualText (phenomena. Changes among networks in different states influence the direction of ) /K [ 23 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 283 0 obj << /ActualText (living organisms) /K [ 24 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 284 0 obj << /ActualText (. The ) /K [ 25 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 285 0 obj << /ActualText (identification ) /K [ 26 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 286 0 obj << /ActualText (of ) /K [ 27 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 287 0 obj << /ActualText (the ) /K [ 28 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 288 0 obj << /ActualText (kernel differential subgraph) /K [ 29 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 289 0 obj << /ActualText ( ) /K [ 30 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 290 0 obj << /ActualText (\(KDS) /K [ 31 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 291 0 obj << /ActualText (\) that lead) /K [ 32 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 292 0 obj << /ActualText (s) /K [ 33 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 293 0 obj << /ActualText ( ) /K [ 34 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> 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377 0 obj << /ActualText (-) /K [ 118 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 378 0 obj << /ActualText (value) /K [ 119 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 379 0 obj << /ActualText (.) /K [ 120 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 380 0 obj << /ActualText ( ) /K [ 121 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 381 0 obj << /ActualText (Hence) /K [ 122 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 382 0 obj << /ActualText (, TKDS) /K [ 123 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 383 0 obj << /ActualText ( ) /K [ 124 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 384 0 obj << /ActualText (discover) /K [ 125 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 385 0 obj << /ActualText (s) /K [ 126 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 386 0 obj << /ActualText ( ) /K [ 127 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 387 0 obj << /ActualText (the ) /K [ 128 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 388 0 obj << /ActualText (essential KDS) /K [ 129 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 389 0 obj << /ActualText (, which) /K [ 130 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 390 0 obj << /ActualText ( ) /K [ 131 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 391 0 obj << /ActualText (considers ) /K [ 132 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 392 0 obj << /ActualText (the relationships) /K [ 133 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 393 0 obj << /ActualText ( ) /K [ 134 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 394 0 obj << /ActualText (between the same nodes ) /K [ 135 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 395 0 obj << /ActualText (as well as) /K [ 136 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 396 0 obj << /ActualText ( ) /K [ 137 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 397 0 obj << /ActualText (different nodes) /K [ 138 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 398 0 obj << /ActualText (.) /K [ 139 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 399 0 obj << /ActualText ( ) /K [ 140 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 400 0 obj << /ActualText (After applying this method to non) /K [ 141 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 401 0 obj << /ActualText (-) /K [ 142 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 402 0 obj << /ActualText (small cell lung cancer \(NSCLC\), we identified 30 genes that ) /K [ 143 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 403 0 obj << /ActualText (are) /K [ 144 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 404 0 obj << /ActualText ( ) /K [ 145 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 405 0 obj << /ActualText (most ) /K [ 146 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 406 0 obj << /ActualText (likely related to NSCLC and extracted the KDSs in both the cancer and normal states. ) /K [ 147 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 407 0 obj << /ActualText (Two ) /K [ 148 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 408 0 obj << /ActualText (significance ) /K [ 149 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 409 0 obj << /ActualText (functional modules ) /K [ 150 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 410 0 obj << /ActualText (we) /K [ 151 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 411 0 obj << /ActualText (re ) /K [ 152 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 412 0 obj << /ActualText (revealed) /K [ 153 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 413 0 obj << /ActualText (, and g) /K [ 154 ] /P 275 0 R /Pg 1 0 R /S /Span /Type /StructElem >> endobj 414 0 obj << /ActualText 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[ 215 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 642 0 obj << /ActualText (genes. ) /K [ 216 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 643 0 obj << /ActualText (B) /K [ 217 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 644 0 obj << /ActualText (agging C3NET) /K [ 218 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 645 0 obj << /ActualText ( ) /K [ 219 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 646 0 obj << /ActualText (\() /K [ 220 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 647 0 obj << /ActualText (BC3NET) /K [ 221 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 648 0 obj << /ActualText (\)) /K [ 222 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 649 0 obj << /ActualText ( ) /K [ 223 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 650 0 obj << /ActualText (is an excellent algorithm for constructing gene regulatory networks ) /K [ 224 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 651 0 obj << /ActualText (\(GRN\) from ) /K [ 225 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 652 0 obj << /ActualText (large) /K [ 226 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 653 0 obj << /ActualText (-) /K [ 227 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 654 0 obj << /ActualText (scale) /K [ 228 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 655 0 obj << /ActualText ( ) /K [ 229 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 656 0 obj << /ActualText (gene expression data. ) /K [ 230 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 657 0 obj << /ActualText (From several copies of independent bootstrap samples, ) /K [ 231 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 658 0 obj << /ActualText (C3NET) /K [ 232 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 659 0 obj << /ActualText (,) /K [ 233 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 660 0 obj << /ActualText ( ) /K [ 234 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 661 0 obj << /ActualText (which corresponds to a Bayesian approach with non) /K [ 235 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 662 0 obj << /ActualText (-) /K [ 236 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 663 0 obj << /ActualText (informative priors) /K [ 237 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 664 0 obj << /ActualText (,) /K [ 238 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 665 0 obj << /ActualText ( ) /K [ 239 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 666 0 obj << /ActualText (deduce) /K [ 240 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 667 0 obj << /ActualText (s) /K [ 241 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 668 0 obj << /ActualText ( ) /K [ 242 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 669 0 obj << /ActualText 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obj << /ActualText (s) /K [ 259 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 686 0 obj << /ActualText ( ) /K [ 260 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 687 0 obj << /ActualText (a weighted network. ) /K [ 261 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 688 0 obj << /ActualText (This) /K [ 262 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 689 0 obj << /ActualText ( ) /K [ 263 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 690 0 obj << /ActualText (method ) /K [ 264 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 691 0 obj << /ActualText (performs) /K [ 265 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 692 0 obj << /ActualText ( ) /K [ 266 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 693 0 obj << /ActualText (well in gene regulatory network inf) /K [ 267 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 694 0 obj << /ActualText (e) /K [ 268 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 695 0 obj << /ActualText (renc) /K [ 269 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 696 0 obj << /ActualText (e) /K [ 270 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 697 0 obj << /ActualText ([) /K [ 271 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 698 0 obj << /K [ 749 0 R 750 0 R ] /P 622 0 R /Pg 3 0 R /S /Link /Type /StructElem >> endobj 699 0 obj << /ActualText (]) /K [ 273 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 700 0 obj << /ActualText (. ) /K [ 274 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 701 0 obj << /ActualText (Genes in the network become ) /K [ 275 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 702 0 obj << /ActualText (up) /K [ 276 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 703 0 obj << /ActualText (-) /K [ 277 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 704 0 obj << /ActualText (regulated or ) /K [ 278 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 705 0 obj << /ActualText (down) /K [ 279 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 706 0 obj << /ActualText (-) /K [ 280 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 707 0 obj << /ActualText (regulate d) /K [ 281 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 708 0 obj << /ActualText (ue to ) /K [ 282 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 709 0 obj << /ActualText (cancer, ageing and death) /K [ 283 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 710 0 obj << /ActualText ( ) /K [ 284 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 711 0 obj << /ActualText (of the life body. ) /K [ 285 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 712 0 obj << /ActualText (Therefore, it is necessary to) /K [ 286 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 713 0 obj << /ActualText ( ) /K [ 287 ] /P 622 0 R /Pg 3 0 R /S 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central module leading to network differential and ) /K [ 297 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 724 0 obj << /ActualText (system mutations) /K [ 298 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 725 0 obj << /ActualText (,) /K [ 299 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 726 0 obj << /ActualText ( ) /K [ 300 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 727 0 obj << /ActualText (to ) /K [ 301 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 728 0 obj << /ActualText (compar) /K [ 302 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 729 0 obj << /ActualText (e) /K [ 303 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 730 0 obj << /ActualText ( ) /K [ 304 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 731 0 obj << /ActualText (the networks ) /K [ 305 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 732 0 obj << /ActualText (in) /K [ 306 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 733 0 obj << /ActualText ( ) /K [ 307 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 734 0 obj << /ActualText (different states.) /K [ 308 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 735 0 obj << /ActualText ( ) /K [ 309 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 736 0 obj << /ActualText (N) /K [ 310 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 737 0 obj << /ActualText (etwork comparison) /K [ 311 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 738 0 obj << /ActualText (s) /K [ 312 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 739 0 obj << /ActualText ( ) /K [ 313 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 740 0 obj << /ActualText (usually ) /K [ 314 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 741 0 obj << /ActualText (include) /K [ 315 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 742 0 obj << /ActualText ( ) /K [ 316 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 743 0 obj << /ActualText (similarity alignment and ) /K [ 317 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 744 0 obj << /ActualText (differential) /K [ 318 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 745 0 obj << /ActualText ( ) /K [ 319 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 746 0 obj << /ActualText (alignment.) /K [ 320 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 747 0 obj << /ActualText ( ) /K [ 321 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 748 0 obj << /ActualText ( ) /K [ 322 ] /P 622 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 749 0 obj << /Obj 203 0 R /Pg 3 0 R /Type /OBJR >> endobj 750 0 obj << /ActualText (2) /K [ 272 ] /P 698 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 751 0 obj << /ActualText (S) /K [ 323 ] /P 752 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 752 0 obj << /K [ 751 0 R 753 0 R 754 0 R 755 0 R 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3 0 R /S /Link /Type /StructElem >> endobj 955 0 obj << /ActualText (]) /K [ 515 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 956 0 obj << /ActualText (.) /K [ 516 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 957 0 obj << /ActualText ( ) /K [ 517 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 958 0 obj << /ActualText (The ) /K [ 518 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 959 0 obj << /ActualText (knowledge) /K [ 519 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 960 0 obj << /ActualText (-) /K [ 520 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 961 0 obj << /ActualText (based differential ) /K [ 521 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 962 0 obj << /ActualText (dependency network) /K [ 522 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 963 0 obj << /ActualText ( ) /K [ 523 ] /P 878 0 R /Pg 3 0 R /S /Span /Type /StructElem >> endobj 964 0 obj << /ActualText (\() 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The results) /K [ 43 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1235 0 obj << /ActualText ( ) /K [ 44 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1236 0 obj << /ActualText (of the ) /K [ 45 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1237 0 obj << /ActualText (experiment) /K [ 46 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1238 0 obj << /ActualText ( ) /K [ 47 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1239 0 obj << /ActualText (including the constructed network, ) /K [ 48 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1240 0 obj << /ActualText (top ) /K [ 49 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1241 0 obj << /ActualText (differential ) /K [ 50 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1242 0 obj << /ActualText (nodes and ) /K [ 51 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1243 0 obj << /ActualText (KDS) /K [ 52 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1244 0 obj << /ActualText (s) /K [ 53 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1245 0 obj << /ActualText (, ) /K [ 54 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1246 0 obj << /ActualText (and the comparative ) /K [ 55 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1247 0 obj << /ActualText (experiment ) /K [ 56 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1248 0 obj << /ActualText (are) /K [ 57 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1249 0 obj << /ActualText ( ) /K [ 58 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1250 0 obj << /ActualText (present) /K [ 59 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1251 0 obj << /ActualText (ed) /K [ 60 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1252 0 obj << /ActualText ( ) /K [ 61 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1253 0 obj << /ActualText (in section 4.) /K [ 62 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1254 0 obj << /ActualText ( ) /K [ 63 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1255 0 obj << /ActualText (We ) /K [ 64 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1256 0 obj << /ActualText (summarize ) /K [ 65 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1257 0 obj << /ActualText (the results ) /K [ 66 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1258 0 obj << /ActualText (of the ) /K [ 67 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1259 0 obj << /ActualText (GO analysis in section 5) /K [ 68 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1260 0 obj << /ActualText (,) /K [ 69 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1261 0 obj << /ActualText ( ) /K [ 70 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1262 0 obj << /ActualText (and ) /K [ 71 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1263 0 obj << /ActualText (finally) /K [ 72 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1264 0 obj << /ActualText (, we ) /K [ 73 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1265 0 obj << /ActualText (conclude ) /K [ 74 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1266 0 obj << /ActualText (our experiment) /K [ 75 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1267 0 obj << /ActualText (s) /K [ 76 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1268 0 obj << /ActualText ( ) /K [ 77 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1269 0 obj << /ActualText (and provide ) /K [ 78 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1270 0 obj << /ActualText (possible futur) /K [ 79 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1271 0 obj << /ActualText (e ) /K [ 80 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1272 0 obj << /ActualText (directions) /K [ 81 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1273 0 obj << /ActualText (.) /K [ 82 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1274 0 obj << /ActualText ( ) /K [ 83 ] /P 1209 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1275 0 obj << /K [ 1276 0 R 1277 0 R 1278 0 R 1279 0 R ] /P 257 0 R /Pg 5 0 R /S /H1 /Type /StructElem >> endobj 1276 0 obj << /ActualText (2) /K [ 84 ] /P 1275 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1277 0 obj << /ActualText ( ) /K [ 85 ] /P 1275 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1278 0 obj << /ActualText (Related work) /K [ 86 ] /P 1275 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1279 0 obj << /ActualText ( ) /K [ 87 ] /P 1275 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1280 0 obj << /K [ 1281 0 R 1282 0 R 1283 0 R 1284 0 R ] /P 257 0 R /Pg 5 0 R /S /H2 /Type /StructElem >> endobj 1281 0 obj << /ActualText (2.1) /K [ 88 ] /P 1280 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1282 0 obj << /ActualText ( ) /K [ 89 ] /P 1280 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1283 0 obj << /ActualText (HGA) /K [ 90 ] /P 1280 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1284 0 obj << /ActualText ( ) /K [ 91 ] /P 1280 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1285 0 obj << /K [ 1286 0 R 1287 0 R 1288 0 R 1289 0 R 1290 0 R 1291 0 R 1292 0 R 1293 0 R 1294 0 R 1295 0 R 1296 0 R 1297 0 R 1298 0 R 1299 0 R 1300 0 R 1301 0 R 1302 0 R 1303 0 R 1304 0 R 1305 0 R 1306 0 R 1307 0 R 1308 0 R 1309 0 R 1310 0 R 1311 0 R 1312 0 R 1313 0 R 1314 0 R 1315 0 R 1316 0 R 1317 0 R 1318 0 R 1319 0 R 1320 0 R 1321 0 R 1322 0 R 1323 0 R 1324 0 R 1325 0 R 1326 0 R 1327 0 R 1328 0 R 1329 0 R 1330 0 R 1331 0 R 1332 0 R 1333 0 R 1334 0 R 1335 0 R 1336 0 R 1337 0 R 1338 0 R 1339 0 R 1340 0 R 1341 0 R 1342 0 R 1343 0 R 1344 0 R 1345 0 R 1346 0 R 1347 0 R 1348 0 R 1349 0 R 1350 0 R 1351 0 R 1352 0 R 1353 0 R 1354 0 R 1355 0 R 1356 0 R 1357 0 R 1358 0 R 1359 0 R 1360 0 R 1361 0 R 1362 0 R 1363 0 R 1364 0 R 1365 0 R 1366 0 R 1367 0 R 1368 0 R 1369 0 R 1370 0 R 1371 0 R 1372 0 R 1373 0 R 1374 0 R 1375 0 R 1376 0 R 1377 0 R 1378 0 R 1379 0 R 1380 0 R 1381 0 R 1382 0 R 1383 0 R 1384 0 R 1385 0 R 1386 0 R 1387 0 R 1388 0 R 1389 0 R 1390 0 R 1391 0 R 1392 0 R 1393 0 R 1394 0 R 1395 0 R 1396 0 R 1397 0 R 1398 0 R 1399 0 R 1400 0 R 1401 0 R 1402 0 R 1403 0 R 1404 0 R 1405 0 R 1406 0 R 1407 0 R 1408 0 R 1409 0 R 1410 0 R 1411 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1286 0 obj << /ActualText ( ) /K [ 92 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1287 0 obj << /ActualText (HGA is an adaptive hybrid algorithm that combines the Hungarian algorithm and the ) /K [ 93 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1288 0 obj << /ActualText (greedy ) /K [ 94 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1289 0 obj << /ActualText (algorithm for the global alignment of biomolecular) /K [ 95 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1290 0 obj << /ActualText ( ) /K [ 96 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1291 0 obj << /ActualText (n) /K [ 97 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1292 0 obj << /ActualText (etworks) /K [ 98 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1293 0 obj << /ActualText ( ) /K [ 99 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1294 0 obj << /ActualText ([) /K [ 100 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1295 0 obj << /K [ 1412 0 R 1413 0 R ] /P 1285 0 R /Pg 5 0 R /S /Link /Type /StructElem >> endobj 1296 0 obj << /ActualText (]) /K [ 102 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1297 0 obj << /ActualText (.) /K [ 103 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1298 0 obj << /ActualText ( ) /K [ 104 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1299 0 obj << /ActualText (The 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114 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1309 0 obj << /ActualText ( ) /K [ 115 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1310 0 obj << /ActualText (the Hungarian algorithm and the greedy ) /K [ 116 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1311 0 obj << /ActualText (algorithm ) /K [ 117 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1312 0 obj << /ActualText (to ) /K [ 118 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1313 0 obj << /ActualText (identify) /K [ 119 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1314 0 obj << /ActualText ( ) /K [ 120 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1315 0 obj << /ActualText (the best mapping) /K [ 121 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1316 0 obj << /ActualText ( ) /K [ 122 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1317 0 obj << /ActualText (between the networks ) /K [ 123 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1318 0 obj << /ActualText (through an) /K [ 124 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1319 0 obj << /ActualText ( ) /K [ 125 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1320 0 obj << /ActualText (iterative process) /K [ 126 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1321 0 obj << /ActualText (.) /K [ 127 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1322 0 obj << /ActualText ( ) /K [ 128 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1323 0 obj << /ActualText (Fig. 1 ) /K [ 129 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1324 0 obj << /ActualText (illustrates) /K [ 130 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1325 0 obj << /ActualText ( ) /K [ 131 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1326 0 obj << /ActualText (the main process of HGA) /K [ 132 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1327 0 obj << /ActualText (.) /K [ 133 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1328 0 obj << /ActualText ( ) /K [ 134 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1329 0 obj << /ActualText (The sequence similarity is computed by BLAST) /K [ 135 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1330 0 obj << /ActualText ([) /K [ 136 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1331 0 obj << /K [ 1414 0 R 1415 0 R ] /P 1285 0 R /Pg 5 0 R /S /Link /Type /StructElem >> endobj 1332 0 obj << /ActualText (]) /K [ 138 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1333 0 obj << /ActualText (,) /K [ 139 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1334 0 obj << /ActualText ( ) /K [ 140 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1335 0 obj << /ActualText (which is ) /K [ 141 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1336 0 obj << /ActualText (a 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/S /Span /Type /StructElem >> endobj 1365 0 obj << /ActualText (updat) /K [ 171 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1366 0 obj << /ActualText (e) /K [ 172 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1367 0 obj << /ActualText (s) /K [ 173 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1368 0 obj << /ActualText ( ) /K [ 174 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1369 0 obj << /ActualText (the similarity matrix) /K [ 175 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1370 0 obj << /ActualText (. For each similarity matrix) /K [ 176 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1371 0 obj << /ActualText (,) /K [ 177 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1372 0 obj << /ActualText ( ) /K [ 178 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1373 0 obj << /ActualText (HGA) /K [ 179 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1374 0 obj << /ActualText ( ) /K [ 180 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1375 0 obj << /ActualText (performs) /K [ 181 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1376 0 obj << /ActualText ( ) /K [ 182 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1377 0 obj << /ActualText (mapping between the two networks) /K [ 183 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1378 0 obj << /ActualText ( ) /K [ 184 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1379 0 obj << /ActualText (and ) /K [ 185 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1380 0 obj << /ActualText (iterate) /K [ 186 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1381 0 obj << /ActualText (s) /K [ 187 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1382 0 obj << /ActualText ( ) /K [ 188 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1383 0 obj << /ActualText (this process) /K [ 189 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1384 0 obj << /ActualText ( ) /K [ 190 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1385 0 obj << /ActualText (u) /K [ 191 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1386 0 obj << /ActualText (ntil the results converge) /K [ 192 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1387 0 obj << /ActualText ( ) /K [ 193 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1388 0 obj << /ActualText (by comput) /K [ 194 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1389 0 obj << /ActualText (ing) /K [ 195 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1390 0 obj << /ActualText ( ) /K [ 196 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1391 0 obj << /ActualText (the ) /K [ 197 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1392 0 obj << /ActualText (e) /K [ 198 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1393 0 obj << /ActualText (dge correctness \() /K [ 199 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1394 0 obj << /ActualText (EC) /K [ 200 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1395 0 obj << /ActualText (\)) /K [ 201 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1396 0 obj << /ActualText ([) /K [ 202 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1397 0 obj << /K [ 1416 0 R 1417 0 R ] /P 1285 0 R /Pg 5 0 R /S /Link /Type /StructElem >> endobj 1398 0 obj << /ActualText (]) /K [ 204 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1399 0 obj << /ActualText ( ) /K [ 205 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1400 0 obj << /ActualText (and ) /K [ 206 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1401 0 obj << /ActualText (the points ) /K [ 207 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1402 0 obj << /ActualText (and edges \() /K [ 208 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1403 0 obj << /ActualText (PE) /K [ 209 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1404 0 obj << /ActualText (\)) /K [ 210 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1405 0 obj << /ActualText ([) /K [ 211 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1406 0 obj << /K [ 1418 0 R 1419 0 R ] /P 1285 0 R /Pg 5 0 R /S /Link /Type /StructElem >> endobj 1407 0 obj << /ActualText (]) /K [ 213 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1408 0 obj << /ActualText ( ) /K [ 214 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1409 0 obj << /ActualText (score) /K [ 215 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1410 0 obj << /ActualText (.) /K [ 216 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1411 0 obj << /ActualText ( ) /K [ 217 ] /P 1285 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1412 0 obj << /Obj 214 0 R /Pg 5 0 R /Type /OBJR >> endobj 1413 0 obj << /ActualText (3) /K [ 101 ] /P 1295 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1414 0 obj << /Obj 215 0 R /Pg 5 0 R /Type /OBJR >> endobj 1415 0 obj << /ActualText (13) /K [ 137 ] /P 1331 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1416 0 obj << /Obj 216 0 R /Pg 5 0 R /Type /OBJR >> endobj 1417 0 obj << /ActualText (14) /K [ 203 ] /P 1397 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1418 0 obj << /Obj 217 0 R /Pg 5 0 R /Type /OBJR >> endobj 1419 0 obj << /ActualText (15) /K [ 212 ] /P 1406 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1420 0 obj << /K [ 1421 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1421 0 obj << /ActualText ( ) /K [ 218 ] /P 1420 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1422 0 obj << /K [ 357 ] /P 257 0 R /Pg 5 0 R /S /Figure /Type /StructElem >> endobj 1423 0 obj << /K [ 1424 0 R 1425 0 R 1426 0 R 1427 0 R 1428 0 R 1429 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1424 0 obj << /ActualText (Fig. 1.) /K [ 219 ] /P 1423 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1425 0 obj << /ActualText ( ) /K [ 220 ] /P 1423 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1426 0 obj << /ActualText (M) /K [ 221 ] /P 1423 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1427 0 obj << /ActualText (ain process of ) /K [ 222 ] /P 1423 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1428 0 obj << /ActualText (HGA) /K [ 223 ] /P 1423 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1429 0 obj << /ActualText ( ) /K [ 224 ] /P 1423 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1430 0 obj << /K [ 1431 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1431 0 obj << /ActualText ( ) /K [ 225 ] /P 1430 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1432 0 obj << /K [ 1433 0 R 1434 0 R 1435 0 R 1436 0 R 1437 0 R 1438 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1433 0 obj << /ActualText (EC scores are typically used to measure degree of topological similarity and can be estimated as a ) /K [ 226 ] /P 1432 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1434 0 obj << /ActualText (percentage of matched edges. ) /K [ 227 ] /P 1432 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1435 0 obj << /ActualText (The ) /K [ 228 ] /P 1432 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1436 0 obj << /ActualText (EC formula is defined as ) /K [ 229 ] /P 1432 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1437 0 obj << /ActualText (follows:) /K [ 230 ] /P 1432 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1438 0 obj << /ActualText ( ) /K [ 231 ] /P 1432 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1439 0 obj << /K [ 1440 0 R 1441 0 R 1442 0 R 1443 0 R 1444 0 R 1445 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1440 0 obj << /ActualText ( ) /K [ 232 ] /P 1439 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1441 0 obj << /ActualText (,) /K [ 234 ] /P 1439 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1442 0 obj << /ActualText ( ) /K [ 235 ] /P 1439 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1443 0 obj << /ActualText (\(1\)) /K [ 236 ] /P 1439 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1444 0 obj << /ActualText ( ) /K [ 237 ] /P 1439 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1445 0 obj << /Alt () /K [ 233 ] /P 1439 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1446 0 obj << /K [ 1447 0 R 1448 0 R 1449 0 R 1450 0 R 1451 0 R 1452 0 R 1453 0 R 1454 0 R 1455 0 R 1456 0 R 1457 0 R 1458 0 R 1459 0 R 1460 0 R 1461 0 R 1462 0 R 1463 0 R 1464 0 R 1465 0 R 1466 0 R 1467 0 R 1468 0 R 1469 0 R 1470 0 R 1471 0 R 1472 0 R 1473 0 R 1474 0 R 1475 0 R 1476 0 R 1477 0 R 1478 0 R 1479 0 R 1480 0 R 1481 0 R 1482 0 R 1483 0 R 1484 0 R 1485 0 R 1486 0 R 1487 0 R 1488 0 R 1489 0 R 1490 0 R 1491 0 R 1492 0 R 1493 0 R 1494 0 R 1495 0 R 1496 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1447 0 obj << /ActualText (where) /K [ 238 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1448 0 obj << /ActualText (represents the edge ) /K [ 240 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1449 0 obj << /ActualText (between) /K [ 241 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1450 0 obj << /ActualText ( ) /K [ 242 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1451 0 obj << /ActualText (node ) /K [ 243 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1452 0 obj << /ActualText ( ) /K [ 245 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1453 0 obj << /ActualText (and ) /K [ 246 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1454 0 obj << /ActualText ( ) /K [ 248 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1455 0 obj << /ActualText (in network A) /K [ 249 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1456 0 obj << /ActualText (;) /K [ 250 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1457 0 obj << /ActualText ( ) /K [ 251 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1458 0 obj << /ActualText ( ) /K [ 253 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1459 0 obj << /ActualText (and ) /K [ 254 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1460 0 obj << /ActualText (mean ) /K [ 256 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1461 0 obj << /ActualText (the) /K [ 257 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1462 0 obj << /ActualText ( ) /K [ 258 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1463 0 obj << /ActualText (mapping nodes of ) /K [ 259 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1464 0 obj << /ActualText ( ) /K [ 260 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1465 0 obj << /ActualText (and ) /K [ 261 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1466 0 obj << /ActualText (, respectively. ) /K [ 262 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1467 0 obj << /ActualText (represents the mapping edge in ) /K [ 264 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1468 0 obj << /ActualText (network B) /K [ 265 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1469 0 obj << /ActualText (;) /K [ 266 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1470 0 obj << /ActualText ( ) /K [ 267 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1471 0 obj << /ActualText (and ) /K [ 268 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1472 0 obj << /ActualText ( ) /K [ 270 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1473 0 obj << /ActualText (and ) /K [ 271 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1474 0 obj << /ActualText ( ) /K [ 273 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1475 0 obj << /ActualText (represent) /K [ 274 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1476 0 obj << /ActualText ( ) /K [ 275 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1477 0 obj << /ActualText (the edge set of network) /K [ 276 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1478 0 obj << /ActualText (s) /K [ 277 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1479 0 obj << /ActualText ( ) /K [ 278 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1480 0 obj << /ActualText (A) /K [ 279 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1481 0 obj << /ActualText ( ) /K [ 280 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1482 0 obj << /ActualText (and B) /K [ 281 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1483 0 obj << /ActualText (,) /K [ 282 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1484 0 obj << /ActualText ( ) /K [ 283 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1485 0 obj << /ActualText (respectively.) /K [ 284 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1486 0 obj << /ActualText ( ) /K [ 285 ] /P 1446 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1487 0 obj << /Alt () /K [ 239 ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1488 0 obj << /Alt () /K [ 244 ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1489 0 obj << /Alt () /K [ 247 ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1490 0 obj << /Alt () /K [ 252 ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1491 0 obj << /Alt () /K [ 255 ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1492 0 obj << /Alt () /K [ ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1493 0 obj << /Alt () /K [ ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1494 0 obj << /Alt () /K [ 263 ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1495 0 obj << /Alt () /K [ 269 ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1496 0 obj << /Alt () /K [ 272 ] /P 1446 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1497 0 obj << /K [ 1498 0 R 1499 0 R 1500 0 R 1501 0 R 1502 0 R 1503 0 R 1504 0 R 1505 0 R 1506 0 R 1507 0 R 1508 0 R 1509 0 R 1510 0 R 1511 0 R 1512 0 R 1513 0 R 1514 0 R 1515 0 R 1516 0 R 1517 0 R 1518 0 R 1519 0 R 1520 0 R 1521 0 R 1522 0 R 1523 0 R 1524 0 R 1525 0 R 1526 0 R 1527 0 R 1528 0 R 1529 0 R 1530 0 R 1531 0 R 1532 0 R 1533 0 R 1534 0 R 1535 0 R 1536 0 R 1537 0 R 1538 0 R 1539 0 R 1540 0 R 1541 0 R 1542 0 R 1543 0 R 1544 0 R 1545 0 R 1546 0 R 1547 0 R 1548 0 R 1549 0 R 1550 0 R 1551 0 R 1552 0 R 1553 0 R 1554 0 R 1555 0 R 1556 0 R 1557 0 R 1558 0 R 1559 0 R 1560 0 R 1561 0 R 1562 0 R 1563 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1498 0 obj << /ActualText ( ) /K [ 286 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1499 0 obj << /ActualText (PE is defined similarly to the measures used by INM) /K [ 287 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1500 0 obj << /ActualText ([) /K [ 288 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1501 0 obj << /K [ 1564 0 R 1565 0 R ] /P 1497 0 R /Pg 5 0 R /S /Link /Type /StructElem >> endobj 1502 0 obj << /ActualText (]) /K [ 290 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1503 0 obj << /ActualText (,) /K [ 291 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1504 0 obj << /ActualText ( ) /K [ 292 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1505 0 obj << /ActualText (which considers both nodes and edges in ) /K [ 293 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1506 0 obj << /ActualText (the score) /K [ 294 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1507 0 obj << /ActualText (.) /K [ 295 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1508 0 obj << /ActualText ( ) /K [ 296 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1509 0 obj << /ActualText (In addition, ) /K [ 297 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1510 0 obj << /ActualText (is the ) /K [ 299 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1511 0 obj << /ActualText (weight) /K [ 300 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1512 0 obj << /ActualText ( ) /K [ 301 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1513 0 obj << /ActualText (of ) /K [ 302 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1514 0 obj << /ActualText (edge) /K [ 303 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1515 0 obj << /ActualText ( ) /K [ 304 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1516 0 obj << /ActualText ( ) /K [ 306 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1517 0 obj << /ActualText (between nodes) /K [ 307 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1518 0 obj << /ActualText ( ) /K [ 308 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1519 0 obj << /ActualText ( ) /K [ 310 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1520 0 obj << /ActualText (and) /K [ 311 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1521 0 obj << /ActualText ( ) /K [ 312 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1522 0 obj << /ActualText ( ) /K [ 314 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1523 0 obj << /ActualText (in network A, ) /K [ 315 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1524 0 obj << /ActualText (which indicates the reliability of this edge.) /K [ 316 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1525 0 obj << /ActualText ( ) /K [ 317 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1526 0 obj << /ActualText ( ) /K [ 319 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1527 0 obj << /ActualText (is the initial similarity score of ) /K [ 320 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1528 0 obj << /ActualText ( ) /K [ 321 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1529 0 obj << /ActualText (and ) /K [ 322 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1530 0 obj << /ActualText (.) /K [ 324 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1531 0 obj << /ActualText ( ) /K [ 325 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1532 0 obj << /ActualText (PE is) /K [ 326 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1533 0 obj << /ActualText ( ) /K [ 327 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1534 0 obj << /ActualText (thus) /K [ 328 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1535 0 obj << /ActualText ( ) /K [ 329 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1536 0 obj << /ActualText (defined as follows.) /K [ 330 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1537 0 obj << /ActualText ( ) /K [ 331 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1538 0 obj << /ActualText (T) /K [ 332 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1539 0 obj << /ActualText (he score for an edge \(the ) /K [ 333 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1540 0 obj << /ActualText (edge score) /K [ 334 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1541 0 obj << /ActualText (, ES\) equals zero if any of its ) /K [ 335 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1542 0 obj << /ActualText (nodes does not match with its similar nodes) /K [ 336 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1543 0 obj << /ActualText ( ) /K [ 337 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1544 0 obj << /ActualText (and that ) /K [ 338 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1545 0 obj << /ActualText (the score for a node \(the ) /K [ 339 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1546 0 obj << /ActualText (point score) /K [ 340 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1547 0 obj << /ActualText (, PS\) equals zero ) /K [ 341 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1548 0 obj << /ActualText (if none of its edges ) /K [ 342 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1549 0 obj << /ActualText (has a score.) /K [ 343 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1550 0 obj << /ActualText ( ) /K [ 344 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1551 0 obj << /ActualText (Therefore, PE is more stringent than EC) /K [ 345 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1552 0 obj << /ActualText ( ) /K [ 346 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1553 0 obj << /ActualText (by considering both nodes and ) /K [ 347 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1554 0 obj << /ActualText (edges) /K [ 348 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1555 0 obj << /ActualText (.) /K [ 349 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1556 0 obj << /ActualText ( ) /K [ 350 ] /P 1497 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1557 0 obj << /Alt () /K [ 298 ] /P 1497 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1558 0 obj << /Alt () /K [ 305 ] /P 1497 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1559 0 obj << /Alt () /K [ 309 ] /P 1497 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1560 0 obj << /Alt () /K [ 313 ] /P 1497 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1561 0 obj << /Alt () /K [ 318 ] /P 1497 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1562 0 obj << /Alt () /K [ ] /P 1497 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1563 0 obj << /Alt () /K [ 323 ] /P 1497 0 R /Pg 5 0 R /S /InlineShape /Type /StructElem >> endobj 1564 0 obj << /Obj 218 0 R /Pg 5 0 R /Type /OBJR >> endobj 1565 0 obj << /ActualText (15) /K [ 289 ] /P 1501 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1566 0 obj << /K [ 1567 0 R 1568 0 R 1569 0 R 1570 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1567 0 obj << /ActualText ( ) /K [ 351 ] /P 1566 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1568 0 obj << /ActualText ( ) /K [ 352 ] /P 1566 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1569 0 obj << /ActualText (\(2\)) /K [ 353 ] /P 1566 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1570 0 obj << /ActualText ( ) /K [ 354 ] /P 1566 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1571 0 obj << /K [ 358 ] /P 257 0 R /Pg 5 0 R /S /Figure /Type /StructElem >> endobj 1572 0 obj << /K [ 1573 0 R 1574 0 R ] /P 257 0 R /Pg 5 0 R /S /P /Type /StructElem >> endobj 1573 0 obj << /ActualText (where) /K [ 355 ] /P 1572 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1574 0 obj << /ActualText ( ) /K [ 356 ] /P 1572 0 R /Pg 5 0 R /S /Span /Type /StructElem >> endobj 1575 0 obj << /K [ 1576 0 R 1577 0 R 1578 0 R 1579 0 R 1580 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1576 0 obj << /ActualText ( ) /K [ 0 ] /P 1575 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1577 0 obj << /ActualText ( ) /K [ 2 ] /P 1575 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1578 0 obj << /ActualText (\(3\)) /K [ 3 ] /P 1575 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1579 0 obj << /ActualText ( ) /K [ 4 ] /P 1575 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1580 0 obj << /Alt () /K [ 1 ] /P 1575 0 R /Pg 25 0 R /S /InlineShape /Type /StructElem >> endobj 1581 0 obj << /K [ 1582 0 R 1583 0 R 1584 0 R 1585 0 R 1586 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1582 0 obj << /ActualText ( ) /K [ 5 ] /P 1581 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1583 0 obj << /ActualText ( ) /K [ 7 ] /P 1581 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1584 0 obj << /ActualText (\(4\)) /K [ 8 ] /P 1581 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1585 0 obj << /ActualText ( ) /K [ 9 ] /P 1581 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1586 0 obj << /Alt () /K [ 6 ] /P 1581 0 R /Pg 25 0 R /S /InlineShape /Type /StructElem >> endobj 1587 0 obj << /K [ 1588 0 R 1589 0 R 1590 0 R 1591 0 R 1592 0 R 1593 0 R ] /P 257 0 R /Pg 25 0 R /S /H2 /Type /StructElem >> endobj 1588 0 obj << /ActualText (2.2 Graphlet and ) /K [ 10 ] /P 1587 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1589 0 obj << /ActualText (g) /K [ 11 ] /P 1587 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1590 0 obj << /ActualText (raphlet) /K [ 12 ] /P 1587 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1591 0 obj << /ActualText ( ) /K [ 13 ] /P 1587 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1592 0 obj << /ActualText (vector) /K [ 14 ] /P 1587 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1593 0 obj << /ActualText ( ) /K [ 15 ] /P 1587 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1594 0 obj << /K [ 1595 0 R 1596 0 R 1597 0 R 1598 0 R 1599 0 R 1600 0 R 1601 0 R 1602 0 R 1603 0 R 1604 0 R 1605 0 R 1606 0 R 1607 0 R 1608 0 R 1609 0 R 1610 0 R 1611 0 R 1612 0 R 1613 0 R 1614 0 R 1615 0 R 1616 0 R 1617 0 R 1618 0 R 1619 0 R 1620 0 R 1621 0 R 1622 0 R 1623 0 R 1624 0 R 1625 0 R 1626 0 R 1627 0 R 1628 0 R 1629 0 R 1630 0 R 1631 0 R 1632 0 R 1633 0 R 1634 0 R 1635 0 R 1636 0 R 1637 0 R 1638 0 R 1639 0 R 1640 0 R 1641 0 R 1642 0 R 1643 0 R 1644 0 R 1645 0 R 1646 0 R 1647 0 R 1648 0 R 1649 0 R 1650 0 R 1651 0 R 1652 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1595 0 obj << /ActualText ( ) /K [ 16 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1596 0 obj << /ActualText (Graphlet) /K [ 17 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1597 0 obj << /ActualText ([) /K [ 18 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1598 0 obj << /K [ 1653 0 R 1654 0 R ] /P 1594 0 R /Pg 25 0 R /S /Link /Type /StructElem >> endobj 1599 0 obj << /ActualText (, ) /K [ 20 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1600 0 obj << /K [ 1655 0 R 1656 0 R ] /P 1594 0 R /Pg 25 0 R /S /Link /Type /StructElem >> endobj 1601 0 obj << /ActualText (, ) /K [ 22 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1602 0 obj << /K [ 1657 0 R 1658 0 R ] /P 1594 0 R /Pg 25 0 R /S /Link /Type /StructElem >> endobj 1603 0 obj << /ActualText (]) /K [ 24 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1604 0 obj << /ActualText ( ) /K [ 25 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1605 0 obj << /ActualText (is a set of non) /K [ 26 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1606 0 obj << /ActualText (-) /K [ 27 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1607 0 obj << /ActualText (isomorphic subnet) /K [ 28 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1608 0 obj << /ActualText (s) /K [ 29 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1609 0 obj << /ActualText ( ) /K [ 30 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1610 0 obj << /ActualText (containing 2, 3, 4 or more nodes. As listed in ) /K [ 31 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1611 0 obj << /ActualText (Fig) /K [ 32 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1612 0 obj << /ActualText (.) /K [ 33 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1613 0 obj << /ActualText ( ) /K [ 34 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1614 0 obj << /ActualText (2) /K [ 35 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1615 0 obj << /ActualText (, the graphlet) /K [ 36 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1616 0 obj << /ActualText (s) /K [ 37 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1617 0 obj << /ActualText ( ) /K [ 38 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1618 0 obj << /ActualText (of 2~4 nodes are easy to understand. ) /K [ 39 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1619 0 obj << /ActualText (For) /K [ 40 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1620 0 obj << /ActualText ( ) /K [ 41 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1621 0 obj << /ActualText (each graphlet) /K [ 42 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1622 0 obj << /ActualText (, nodes with ) /K [ 43 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1623 0 obj << /ActualText (the ) /K [ 44 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1624 0 obj << /ActualText (same topology ) /K [ 45 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1625 0 obj << /ActualText (\(degree\) are ) /K [ 46 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1626 0 obj << /ActualText (indicated ) /K [ 47 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1627 0 obj << /ActualText (in ) /K [ 48 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1628 0 obj << /ActualText (the ) /K [ 49 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1629 0 obj << /ActualText (same ) /K [ 50 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1630 0 obj << /ActualText (colour ) /K [ 51 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1631 0 obj << /ActualText (and vice versa. Therefor) /K [ 52 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1632 0 obj << /ActualText (e,) /K [ 53 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1633 0 obj << /ActualText ( ) /K [ 54 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1634 0 obj << /ActualText (we can ) /K [ 55 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1635 0 obj << /ActualText (obtain ) /K [ 56 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1636 0 obj << /ActualText (15 different ) /K [ 57 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1637 0 obj << /ActualText (orbits) /K [ 58 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1638 0 obj << /ActualText ( ) /K [ 59 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1639 0 obj << /ActualText (labelled ) /K [ 60 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1640 0 obj << /ActualText (0~14. For a specific node in) /K [ 61 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1641 0 obj << /ActualText ( ) /K [ 62 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1642 0 obj << /ActualText (a) /K [ 63 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1643 0 obj << /ActualText ( ) /K [ 64 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1644 0 obj << /ActualText (network, we consider all combinations and ) /K [ 65 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1645 0 obj << /ActualText (obtain) /K [ 66 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1646 0 obj << /ActualText ( ) /K [ 67 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1647 0 obj << /ActualText (the frequency ) /K [ 68 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1648 0 obj << /ActualText (in 15 dimensions) /K [ 69 ] /P 1594 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1649 0 obj << /ActualText (; we 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1669 0 R 1670 0 R 1671 0 R 1672 0 R 1673 0 R 1674 0 R 1675 0 R 1676 0 R 1677 0 R 1678 0 R 1679 0 R 1680 0 R 1681 0 R 1682 0 R 1683 0 R 1684 0 R 1685 0 R 1686 0 R 1687 0 R 1688 0 R 1689 0 R 1690 0 R 1691 0 R 1692 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1660 0 obj << /ActualText ( ) /K [ 74 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1661 0 obj << /ActualText (As ) /K [ 75 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1662 0 obj << /ActualText (shown ) /K [ 76 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1663 0 obj << /ActualText (in Fig) /K [ 77 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1664 0 obj << /ActualText (.) /K [ 78 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1665 0 obj << /ActualText ( ) /K [ 79 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1666 0 obj << /ActualText (2) /K [ 80 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1667 0 obj << 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obj << /ActualText ( ) /K [ 90 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1677 0 obj << /ActualText (introduce) /K [ 91 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1678 0 obj << /ActualText (d) /K [ 92 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1679 0 obj << /ActualText ( ) /K [ 93 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1680 0 obj << /ActualText (a weight for each dimension of the graphlet vector. ) /K [ 94 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1681 0 obj << /ActualText (H) /K [ 95 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1682 0 obj << /ActualText (igher ) /K [ 96 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1683 0 obj << /ActualText (dimension) /K [ 97 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1684 0 obj << /ActualText (s) /K [ 98 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1685 0 obj << /ActualText ( ) /K [ 99 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1686 0 obj << /ActualText (typically ) /K [ 100 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1687 0 obj << /ActualText (contain the) /K [ 101 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1688 0 obj << /ActualText ( ) /K [ 102 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1689 0 obj << /ActualText (smaller ) /K [ 103 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1690 0 obj << /ActualText (dimensions) /K [ 104 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1691 0 obj << /ActualText (.) /K [ 105 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1692 0 obj << /ActualText ( ) /K [ 106 ] /P 1659 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1693 0 obj << /K [ 1694 0 R 1695 0 R 1696 0 R 1697 0 R 1698 0 R 1699 0 R 1700 0 R 1701 0 R 1702 0 R 1703 0 R 1704 0 R 1705 0 R 1706 0 R 1707 0 R 1708 0 R 1709 0 R 1710 0 R 1711 0 R 1712 0 R 1713 0 R 1714 0 R 1715 0 R 1716 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1694 0 obj << /ActualText ( ) /K [ 107 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1695 0 obj << /ActualText (The graphlet ) /K [ 108 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1696 0 obj << /ActualText (vector elaborately depicts the topological relation between a node and its specified ) /K [ 109 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1697 0 obj << /ActualText (number of nearest ) /K [ 110 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1698 0 obj << /ActualText (neighbours) /K [ 111 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1699 0 obj << /ActualText (. When the local structure changes in ) /K [ 112 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1700 0 obj << /ActualText (a ) /K [ 113 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1701 0 obj << /ActualText (network, the graphlet vector for ) /K [ 114 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1702 0 obj << /ActualText (relative nodes changes accordingly. ) /K [ 115 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1703 0 obj << /ActualText (The more) /K [ 116 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1704 0 obj << /ActualText ( ) /K [ 117 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1705 0 obj << /ActualText (the) /K [ 118 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1706 0 obj << /ActualText ( ) /K [ 119 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1707 0 obj << /ActualText (local structure ) /K [ 120 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1708 0 obj << /ActualText (changes) /K [ 121 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1709 0 obj << /ActualText (, the more likely) /K [ 122 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1710 0 obj << /ActualText ( ) /K [ 123 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1711 0 obj << /ActualText (it becomes that) /K [ 124 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1712 0 obj << /ActualText ( ) /K [ 125 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1713 0 obj << /ActualText (the primary graphlet vector ) /K [ 126 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1714 0 obj << /ActualText (varies as well) /K [ 127 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1715 0 obj << /ActualText (.) /K [ 128 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1716 0 obj << /ActualText ( ) /K [ 129 ] /P 1693 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1717 0 obj << /K [ 1718 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1718 0 obj << /ActualText ( ) /K [ 130 ] /P 1717 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1719 0 obj << /K [ 379 ] /P 257 0 R /Pg 25 0 R /S /Figure /Type /StructElem >> endobj 1720 0 obj << /K [ 1721 0 R 1722 0 R 1723 0 R 1724 0 R 1725 0 R 1726 0 R 1727 0 R 1728 0 R 1729 0 R 1730 0 R 1731 0 R 1732 0 R 1733 0 R 1734 0 R 1735 0 R 1736 0 R 1737 0 R 1738 0 R 1739 0 R 1740 0 R 1741 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1721 0 obj << /ActualText (Fig. ) /K [ 131 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1722 0 obj << /ActualText (2) /K [ 132 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1723 0 obj << /ActualText (.) /K [ 133 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1724 0 obj << /ActualText ( ) /K [ 134 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1725 0 obj << /ActualText (2~4) /K [ 135 ] /P 1720 0 R /Pg 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[ 145 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1736 0 obj << /ActualText ([) /K [ 146 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1737 0 obj << /K [ 1742 0 R 1743 0 R ] /P 1720 0 R /Pg 25 0 R /S /Link /Type /StructElem >> endobj 1738 0 obj << /ActualText (]) /K [ 148 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1739 0 obj << /ActualText (.) /K [ 149 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1740 0 obj << /ActualText ( ) /K [ 150 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1741 0 obj << /ActualText ( ) /K [ 151 ] /P 1720 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1742 0 obj << /Obj 222 0 R /Pg 25 0 R /Type /OBJR >> endobj 1743 0 obj << /ActualText (4) /K [ 147 ] /P 1737 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1744 0 obj << /K [ 1745 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1745 0 obj << /ActualText ( ) /K [ 152 ] /P 1744 0 R /Pg 25 0 R /S /Span /Type 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1880 0 R 1881 0 R 1882 0 R 1883 0 R 1884 0 R 1885 0 R 1886 0 R 1887 0 R 1888 0 R 1889 0 R 1890 0 R 1891 0 R 1892 0 R 1893 0 R 1894 0 R 1895 0 R 1896 0 R 1897 0 R 1898 0 R 1899 0 R 1900 0 R 1901 0 R 1902 0 R 1903 0 R 1904 0 R 1905 0 R 1906 0 R 1907 0 R 1908 0 R 1909 0 R 1910 0 R 1911 0 R 1912 0 R 1913 0 R 1914 0 R 1915 0 R 1916 0 R 1917 0 R 1918 0 R 1919 0 R 1920 0 R 1921 0 R 1922 0 R 1923 0 R 1924 0 R 1925 0 R 1926 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1825 0 obj << /ActualText ( ) /K [ 228 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1826 0 obj << /ActualText (Networks in ) /K [ 229 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1827 0 obj << /ActualText (two) /K [ 230 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1828 0 obj << /ActualText ( ) /K [ 231 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1829 0 obj << /ActualText (states are represented as ) /K [ 232 ] /P 1824 0 R /Pg 25 0 R /S /Span 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/Pg 25 0 R /S /Span /Type /StructElem >> endobj 1840 0 obj << /ActualText (represent the ) /K [ 247 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1841 0 obj << /ActualText (nodes set) /K [ 248 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1842 0 obj << /ActualText (; ) /K [ 249 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1843 0 obj << /ActualText ( ) /K [ 251 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1844 0 obj << /ActualText (and) /K [ 252 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1845 0 obj << /ActualText ( ) /K [ 253 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1846 0 obj << /ActualText ( ) /K [ 255 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1847 0 obj << /ActualText (represent the edges set) /K [ 256 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1848 0 obj << /ActualText (; ) /K [ 257 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1849 0 obj << /ActualText (and) /K [ 258 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1850 0 obj << /ActualText ( ) /K [ 259 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1851 0 obj << /ActualText (,) /K [ 261 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1852 0 obj << /ActualText ( ) /K [ 262 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1853 0 obj << /ActualText (,) /K [ 264 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1854 0 obj << /ActualText ( ) /K [ 265 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1855 0 obj << /ActualText (,) /K [ 267 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1856 0 obj << /ActualText ( ) /K [ 268 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1857 0 obj << /ActualText (and ) /K [ 269 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1858 0 obj << /ActualText ( ) /K [ 271 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1859 0 obj << /ActualText (represent ) /K [ 272 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1860 0 obj << /ActualText (the ) /K [ 273 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1861 0 obj << /ActualText (numbers) /K [ 274 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1862 0 obj << /ActualText ( ) /K [ 275 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1863 0 obj << /ActualText (of nodes and edges, respectively, ) /K [ 276 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1864 0 obj << /ActualText (in network) /K [ 277 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1865 0 obj << /ActualText (s ) /K [ 278 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1866 0 obj << /ActualText ( ) /K [ 280 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1867 0 obj << /ActualText (and) /K [ 281 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1868 0 obj << /ActualText ( ) /K [ 282 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1869 0 obj << /ActualText (.) /K [ 284 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1870 0 obj << /ActualText ( ) /K [ 285 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1871 0 obj << /ActualText (Generally) /K [ 286 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1872 0 obj << /ActualText (,) /K [ 287 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1873 0 obj << /ActualText ( ) /K [ 288 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1874 0 obj << /ActualText (the number of nodes in ) /K [ 289 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1875 0 obj << /ActualText (the two networks may) /K [ 290 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1876 0 obj << /ActualText ( ) /K [ 291 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1877 0 obj << /ActualText (be different.) /K [ 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obj << /ActualText ( ) /K [ 312 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1897 0 obj << /ActualText (same nodes are ) /K [ 313 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1898 0 obj << /ActualText (grouped ) /K [ 314 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1899 0 obj << /ActualText (together) /K [ 315 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1900 0 obj << /ActualText (. ) /K [ 316 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1901 0 obj << /ActualText (For ) /K [ 317 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1902 0 obj << /ActualText (different nodes in the smaller network, ) /K [ 318 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1903 0 obj << /ActualText (the) /K [ 319 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1904 0 obj << /ActualText ( ) /K [ 320 ] /P 1824 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1905 0 obj << /ActualText 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0 R /S /InlineShape /Type /StructElem >> endobj 1925 0 obj << /Alt () /K [ 283 ] /P 1824 0 R /Pg 25 0 R /S /InlineShape /Type /StructElem >> endobj 1926 0 obj << /Alt () /K [ 302 ] /P 1824 0 R /Pg 25 0 R /S /InlineShape /Type /StructElem >> endobj 1927 0 obj << /K [ 1928 0 R 1929 0 R 1930 0 R 1931 0 R 1932 0 R 1933 0 R 1934 0 R 1935 0 R 1936 0 R 1937 0 R 1938 0 R 1939 0 R 1940 0 R 1941 0 R 1942 0 R 1943 0 R 1944 0 R 1945 0 R 1946 0 R 1947 0 R 1948 0 R 1949 0 R 1950 0 R 1951 0 R 1952 0 R 1953 0 R 1954 0 R 1955 0 R 1956 0 R 1957 0 R 1958 0 R 1959 0 R 1960 0 R 1961 0 R 1962 0 R 1963 0 R 1964 0 R 1965 0 R 1966 0 R 1967 0 R 1968 0 R 1969 0 R 1970 0 R 1971 0 R 1972 0 R 1973 0 R 1974 0 R 1975 0 R 1976 0 R ] /P 257 0 R /Pg 25 0 R /S /P /Type /StructElem >> endobj 1928 0 obj << /ActualText ( ) /K [ 330 ] /P 1927 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1929 0 obj << /ActualText (For ) /K [ 331 ] /P 1927 0 R /Pg 25 0 R /S /Span /Type /StructElem >> endobj 1930 0 obj << /ActualText 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0 R 2034 0 R 2035 0 R 2036 0 R 2037 0 R 2038 0 R 2039 0 R 2040 0 R 2041 0 R 2042 0 R 2043 0 R 2044 0 R 2045 0 R 2046 0 R 2047 0 R 2048 0 R 2049 0 R 2050 0 R 2051 0 R 2052 0 R 2053 0 R 2054 0 R 2055 0 R 2056 0 R 2057 0 R 2058 0 R ] /P 257 0 R /Pg 46 0 R /S /P /Type /StructElem >> endobj 1987 0 obj << /ActualText (w) /K [ 8 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 1988 0 obj << /ActualText (here) /K [ 9 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 1989 0 obj << /ActualText ( ) /K [ 10 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 1990 0 obj << /ActualText ( ) /K [ 12 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 1991 0 obj << /ActualText (and) /K [ 13 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 1992 0 obj << /ActualText ( ) /K [ 14 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 1993 0 obj << /ActualText ( ) /K [ 16 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 1994 0 obj 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27 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2004 0 obj << /ActualText ( ) /K [ 28 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2005 0 obj << /ActualText ( ) /K [ 30 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2006 0 obj << /ActualText (and) /K [ 31 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2007 0 obj << /ActualText ( ) /K [ 32 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2008 0 obj << /ActualText ( ) /K [ 34 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2009 0 obj << /ActualText (and) /K [ 35 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2010 0 obj << /ActualText ( ) /K [ 36 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2011 0 obj << /ActualText ( ) /K [ 38 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2012 0 obj << /ActualText (is ) /K [ 39 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2013 0 obj << /ActualText 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1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2033 0 obj << /ActualText (, the ) /K [ 62 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2034 0 obj << /ActualText (similarity) /K [ 63 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2035 0 obj << /ActualText ( ) /K [ 64 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2036 0 obj << /ActualText (.) /K [ 66 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2037 0 obj << /ActualText ( ) /K [ 67 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2038 0 obj << /ActualText (Then, ) /K [ 68 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2039 0 obj << /ActualText (across the top D) /K [ 69 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2040 0 obj << /ActualText (-) /K [ 70 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2041 0 obj << /ActualText (value nodes, ) /K [ 71 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2042 0 obj << /ActualText (the ) /K [ 72 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2043 0 obj << /ActualText (KDS ) /K [ 73 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2044 0 obj << /ActualText (can ) /K [ 74 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2045 0 obj << /ActualText (be extracted using the proposed ) /K [ 75 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2046 0 obj << /ActualText (TKDS ) /K [ 76 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2047 0 obj << /ActualText (method.) /K [ 77 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2048 0 obj << /ActualText ( ) /K [ 78 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2049 0 obj << /ActualText ( ) /K [ 79 ] /P 1986 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2050 0 obj << /Alt () /K [ 11 ] /P 1986 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2051 0 obj << /Alt () /K [ 15 ] /P 1986 0 R 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0 obj << /ActualText (the ) /K [ 243 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2235 0 obj << /ActualText (genes ) /K [ 244 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2236 0 obj << /ActualText (in the ) /K [ 245 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2237 0 obj << /ActualText (mentioned) /K [ 246 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2238 0 obj << /ActualText ( ) /K [ 247 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2239 0 obj << /ActualText (pathway.) /K [ 248 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2240 0 obj << /ActualText ( ) /K [ 249 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2241 0 obj << /ActualText (By controlling the correlation coefficient, we ) /K [ 250 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2242 0 obj << /ActualText (obtained ) /K [ 251 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2243 0 obj << 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[ 273 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2263 0 obj << /ActualText (e use) /K [ 274 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2264 0 obj << /ActualText (d) /K [ 275 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2265 0 obj << /ActualText ( ) /K [ 276 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2266 0 obj << /ActualText (BC3NET to construct the two network) /K [ 277 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2267 0 obj << /ActualText (s ) /K [ 278 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2268 0 obj << /ActualText ( ) /K [ 280 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2269 0 obj << /ActualText (and) /K [ 281 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2270 0 obj << /ActualText ( ) /K [ 282 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2271 0 obj << /ActualText ( ) /K [ 283 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2272 0 obj << /ActualText (based on the gene expression ) /K [ 284 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2273 0 obj << /ActualText (matrix) /K [ 285 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2274 0 obj << /ActualText (.) /K [ 286 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2275 0 obj << /ActualText ( ) /K [ 287 ] /P 2104 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2276 0 obj << /Alt () /K [ 266 ] /P 2104 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2277 0 obj << /Alt () /K [ 270 ] /P 2104 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2278 0 obj << /Alt () /K [ 279 ] /P 2104 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2279 0 obj << /K [ 437 ] /P 257 0 R /Pg 46 0 R /S /Figure /Type /StructElem >> endobj 2280 0 obj << /K [ 2281 0 R 2282 0 R 2283 0 R 2284 0 R 2285 0 R 2286 0 R ] /P 257 0 R /Pg 46 0 R /S /H2 /Type /StructElem >> endobj 2281 0 obj << 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46 0 R /S /Span /Type /StructElem >> endobj 2325 0 obj << /ActualText (is) /K [ 337 ] /P 2287 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2326 0 obj << /ActualText ( ) /K [ 338 ] /P 2287 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2327 0 obj << /ActualText (the) /K [ 339 ] /P 2287 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2328 0 obj << /ActualText ( ) /K [ 340 ] /P 2287 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2329 0 obj << /ActualText (most ) /K [ 341 ] /P 2287 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2330 0 obj << /ActualText (similar ) /K [ 342 ] /P 2287 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2331 0 obj << /ActualText (gene in) /K [ 343 ] /P 2287 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2332 0 obj << /ActualText ( ) /K [ 344 ] /P 2287 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2333 0 obj << /ActualText (. 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2370 0 obj << /ActualText ( ) /K [ 374 ] /P 2361 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2371 0 obj << /ActualText (, ) /K [ 376 ] /P 2361 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2372 0 obj << /ActualText ( ) /K [ 378 ] /P 2361 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2373 0 obj << /ActualText (and) /K [ 379 ] /P 2361 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2374 0 obj << /ActualText ( ) /K [ 380 ] /P 2361 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2375 0 obj << /ActualText (.) /K [ 382 ] /P 2361 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2376 0 obj << /ActualText ( ) /K [ 383 ] /P 2361 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2377 0 obj << /Alt () /K [ 371 ] /P 2361 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2378 0 obj << /Alt () /K [ 375 ] /P 2361 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2379 0 obj << /Alt () /K [ 377 ] /P 2361 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2380 0 obj << /Alt () /K [ 381 ] /P 2361 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2381 0 obj << /K [ 2382 0 R 2383 0 R 2384 0 R 2385 0 R 2386 0 R 2387 0 R 2388 0 R 2389 0 R 2390 0 R 2391 0 R ] /P 257 0 R /Pg 46 0 R /S /H2 /Type /StructElem >> endobj 2382 0 obj << /ActualText (3) /K [ 384 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2383 0 obj << /ActualText (.) /K [ 385 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2384 0 obj << /ActualText (4) /K [ 386 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2385 0 obj << /ActualText ( ) /K [ 387 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2386 0 obj << /ActualText (Differential) /K [ 388 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2387 0 obj << /ActualText ( ) /K [ 389 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2388 0 obj << /ActualText (gene) /K [ 390 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2389 0 obj << /ActualText ( ) /K [ 391 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2390 0 obj << /ActualText (extraction) /K [ 392 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2391 0 obj << /ActualText ( ) /K [ 393 ] /P 2381 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2392 0 obj << /K [ 2393 0 R 2394 0 R 2395 0 R 2396 0 R 2397 0 R 2398 0 R 2399 0 R 2400 0 R 2401 0 R 2402 0 R 2403 0 R 2404 0 R 2405 0 R 2406 0 R 2407 0 R 2408 0 R 2409 0 R 2410 0 R 2411 0 R 2412 0 R 2413 0 R 2414 0 R 2415 0 R 2416 0 R 2417 0 R 2418 0 R 2419 0 R 2420 0 R 2421 0 R 2422 0 R 2423 0 R 2424 0 R 2425 0 R 2426 0 R 2427 0 R 2428 0 R 2429 0 R 2430 0 R 2431 0 R 2432 0 R 2433 0 R 2434 0 R ] /P 257 0 R /Pg 46 0 R /S /P /Type /StructElem >> endobj 2393 0 obj << /ActualText ( ) /K [ 394 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2394 0 obj << /ActualText (As described in ) /K [ 395 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2395 0 obj << /ActualText (s) /K [ 396 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2396 0 obj << /ActualText (ection ) /K [ 397 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2397 0 obj << /ActualText (3) /K [ 398 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2398 0 obj << /ActualText (.) /K [ 399 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2399 0 obj << /ActualText (3) /K [ 400 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2400 0 obj << /ActualText (, when we match the two GRN) /K [ 401 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2401 0 obj << /ActualText (s) /K [ 402 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2402 0 obj << /ActualText (, each node in ) /K [ 403 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2403 0 obj << /ActualText (the ) /K [ 404 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2404 0 obj << /ActualText (small network) /K [ 405 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2405 0 obj << /ActualText (matches to ) /K [ 407 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2406 0 obj << /ActualText (a corresponding node in) /K [ 408 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2407 0 obj << /ActualText ( ) /K [ 409 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2408 0 obj << /ActualText (, ) /K [ 411 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2409 0 obj << /ActualText (and the mismatched node) /K [ 412 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2410 0 obj << /ActualText (s) /K [ 413 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2411 0 obj << /ActualText ( ) /K [ 414 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2412 0 obj << /ActualText (in) /K [ 415 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2413 0 obj << /ActualText ( ) /K [ 416 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2414 0 obj << /ActualText ( ) /K [ 418 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2415 0 obj << /ActualText (are) /K [ 419 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2416 0 obj << /ActualText ( ) /K [ 420 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2417 0 obj << /ActualText (deleted. ) /K [ 421 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2418 0 obj << /ActualText (In fact, ) /K [ 422 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2419 0 obj << /ActualText (t) /K [ 423 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2420 0 obj << /ActualText (here are ) /K [ 424 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2421 0 obj << /ActualText (fewer nodes without ) /K [ 425 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2422 0 obj << /ActualText (matches) /K [ 426 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2423 0 obj << /ActualText ( ) /K [ 427 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2424 0 obj << /ActualText (b) /K [ 428 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2425 0 obj << /ActualText (ecause we can control the scale of the ) /K [ 429 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2426 0 obj << /ActualText (larger ) /K [ 430 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2427 0 obj << /ActualText (network) /K [ 431 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2428 0 obj << /ActualText ( ) /K [ 432 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2429 0 obj << /ActualText ( ) /K [ 434 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2430 0 obj << /ActualText (before using ) /K [ 435 ] /P 2392 0 R /Pg 46 0 R /S /Span /Type /StructElem >> endobj 2431 0 obj << /Alt () /K [ 406 ] /P 2392 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2432 0 obj << /Alt () /K [ 410 ] /P 2392 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2433 0 obj << /Alt () /K [ 417 ] /P 2392 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2434 0 obj << /Alt () /K [ 433 ] /P 2392 0 R /Pg 46 0 R /S /InlineShape /Type /StructElem >> endobj 2435 0 obj << /K [ 2436 0 R 2437 0 R 2438 0 R 2439 0 R 2440 0 R 2441 0 R 2442 0 R 2443 0 R 2444 0 R 2445 0 R 2446 0 R 2447 0 R 2448 0 R 2449 0 R 2450 0 R 2451 0 R 2452 0 R 2453 0 R 2454 0 R 2455 0 R 2456 0 R 2457 0 R 2458 0 R 2459 0 R 2460 0 R 2461 0 R 2462 0 R 2463 0 R 2464 0 R 2465 0 R 2466 0 R 2467 0 R 2468 0 R 2469 0 R 2470 0 R 2471 0 R 2472 0 R 2473 0 R 2474 0 R 2475 0 R 2476 0 R 2477 0 R 2478 0 R 2479 0 R 2480 0 R 2481 0 R 2482 0 R 2483 0 R 2484 0 R 2485 0 R 2486 0 R 2487 0 R 2488 0 R 2489 0 R 2490 0 R 2491 0 R 2492 0 R 2493 0 R 2494 0 R 2495 0 R 2496 0 R 2497 0 R 2498 0 R 2499 0 R 2500 0 R 2501 0 R 2502 0 R 2503 0 R 2504 0 R 2505 0 R 2506 0 R 2507 0 R 2508 0 R 2509 0 R 2510 0 R 2511 0 R 2512 0 R 2513 0 R 2514 0 R 2515 0 R 2516 0 R 2517 0 R 2518 0 R 2519 0 R 2520 0 R 2521 0 R 2522 0 R 2523 0 R 2524 0 R 2525 0 R 2526 0 R 2527 0 R 2528 0 R 2529 0 R 2530 0 R 2531 0 R 2532 0 R 2533 0 R 2534 0 R 2535 0 R 2536 0 R 2537 0 R 2538 0 R 2539 0 R 2540 0 R 2541 0 R 2542 0 R 2543 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2436 0 obj << /ActualText (HGA) /K [ 0 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2437 0 obj << /ActualText ( ) /K [ 1 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2438 0 obj << /ActualText (for ) /K [ 2 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2439 0 obj << /ActualText (the ) /K [ 3 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2440 0 obj << /ActualText (alignment) /K [ 4 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2441 0 obj << /ActualText (.) /K [ 5 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2442 0 obj << /ActualText ( ) /K [ 6 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2443 0 obj << /ActualText (For example, we can control the scale by) /K [ 7 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2444 0 obj << /ActualText ( ) /K [ 8 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2445 0 obj << /ActualText (choos) /K [ 9 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2446 0 obj << /ActualText (ing) /K [ 10 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2447 0 obj << /ActualText ( ) /K [ 11 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2448 0 obj << /ActualText (a subnet ) /K [ 12 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2449 0 obj << /ActualText (that ) /K [ 13 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2450 0 obj << /ActualText (includ) /K [ 14 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2451 0 obj << /ActualText (es) /K [ 15 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2452 0 obj << /ActualText ( ) /K [ 16 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2453 0 obj << /ActualText (the ) /K [ 17 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2454 0 obj << /ActualText (genes in) /K [ 18 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2455 0 obj << /ActualText ( ) /K [ 19 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2456 0 obj << /ActualText (a) /K [ 20 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2457 0 obj << /ActualText ( ) /K [ 21 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2458 0 obj << /ActualText (pathway and their ) /K [ 22 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2459 0 obj << /ActualText (first, second or third ) /K [ 23 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2460 0 obj << /ActualText (neighbours) /K [ 24 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2461 0 obj << /ActualText (.) /K [ 25 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2462 0 obj << /ActualText ( ) /K [ 26 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2463 0 obj << /ActualText (For the same node pairs) /K [ 27 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2464 0 obj << /ActualText ( ) /K [ 28 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2465 0 obj << /ActualText (, ) /K [ 30 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2466 0 obj << /ActualText (we can ) /K [ 31 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2467 0 obj << /ActualText (calculate) /K [ 32 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2468 0 obj << /ActualText ( ) /K [ 33 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2469 0 obj << /ActualText (the D) /K [ 34 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2470 0 obj << /ActualText (-) /K [ 35 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2471 0 obj << /ActualText (value) /K [ 36 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2472 0 obj << /ActualText ( ) /K [ 37 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2473 0 obj << /ActualText ( ) /K [ 39 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2474 0 obj << /ActualText (according to ) /K [ 40 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2475 0 obj << /ActualText (its topology) /K [ 41 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2476 0 obj << /ActualText ( ) /K [ 42 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2477 0 obj << /ActualText (distribution) /K [ 43 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2478 0 obj << /ActualText (. ) /K [ 44 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2479 0 obj << /ActualText (For different ) /K [ 45 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2480 0 obj << /ActualText (node pairs) /K [ 46 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2481 0 obj << /ActualText ( ) /K [ 47 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2482 0 obj << /ActualText ( ) /K [ 49 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2483 0 obj << /ActualText (that ) /K [ 50 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2484 0 obj << /ActualText (belong to the relationship ) /K [ 51 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2485 0 obj << /ActualText (in) /K [ 52 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2486 0 obj << /ActualText (,) /K [ 54 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2487 0 obj << /ActualText ( ) /K [ 55 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2488 0 obj << /ActualText (we also consider the nucleotide sequence similarity) /K [ 56 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2489 0 obj << /ActualText ( ) /K [ 57 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2490 0 obj << /ActualText (.) /K [ 59 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2491 0 obj << /ActualText ( ) /K [ 60 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2492 0 obj << /ActualText (Tijana ) /K [ 61 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2493 0 obj << /ActualText (et al) /K [ 62 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2494 0 obj << /ActualText (.) /K [ 63 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2495 0 obj << /ActualText ( ) /K [ 64 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2496 0 obj << /ActualText (propose) /K [ 65 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2497 0 obj << /ActualText (d) /K [ 66 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2498 0 obj << /ActualText ( ) /K [ 67 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2499 0 obj << /ActualText (that) /K [ 68 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2500 0 obj << /ActualText ( ) /K [ 69 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2501 0 obj << /ActualText ( ) /K [ 71 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2502 0 obj << /ActualText (and) /K [ 72 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2503 0 obj << /ActualText ( ) /K [ 73 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2504 0 obj << /ActualText ( ) /K [ 75 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2505 0 obj << /ActualText (change) /K [ 76 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2506 0 obj << /ActualText ( ) /K [ 77 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2507 0 obj << /ActualText (appreciably ) /K [ 78 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2508 0 obj << /ActualText (if) /K [ 79 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2509 0 obj << /ActualText ( ) /K [ 80 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2510 0 obj << /ActualText ([) /K [ 82 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2511 0 obj << /K [ 2544 0 R 2545 0 R ] /P 2435 0 R /Pg 80 0 R /S /Link /Type /StructElem >> endobj 2512 0 obj << /ActualText (]) /K [ 84 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2513 0 obj << /ActualText (. ) /K [ 85 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2514 0 obj << /ActualText (Thus) /K [ 86 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2515 0 obj << /ActualText (, ) /K [ 87 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2516 0 obj << /ActualText (we ) /K [ 88 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2517 0 obj << /ActualText (selected ) /K [ 89 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2518 0 obj << /ActualText (the ) /K [ 90 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2519 0 obj << /ActualText (appreciably ) /K [ 91 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2520 0 obj << /ActualText (changing ) /K [ 92 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2521 0 obj << /ActualText (gene) /K [ 93 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2522 0 obj << /ActualText ( ) /K [ 94 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2523 0 obj << /ActualText (set) /K [ 95 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2524 0 obj << /ActualText ( ) /K [ 96 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2525 0 obj << /ActualText (,) /K [ 98 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2526 0 obj << /ActualText ( ) /K [ 99 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2527 0 obj << /ActualText (and these genes ) /K [ 100 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2528 0 obj << /ActualText (represent the ) /K [ 101 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2529 0 obj << /ActualText (most ) /K [ 102 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2530 0 obj << /ActualText (important ) /K [ 103 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2531 0 obj << /ActualText (genes ) /K [ 104 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2532 0 obj << /ActualText (across the dynamic process) /K [ 105 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2533 0 obj << /ActualText (.) /K [ 106 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2534 0 obj << /ActualText ( ) /K [ 107 ] /P 2435 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2535 0 obj << /Alt () /K [ 29 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2536 0 obj << /Alt () /K [ 38 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2537 0 obj << /Alt () /K [ 48 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2538 0 obj << /Alt () /K [ 53 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2539 0 obj << /Alt () /K [ 58 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2540 0 obj << /Alt () /K [ 70 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2541 0 obj << /Alt () /K [ 74 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2542 0 obj << /Alt () /K [ 81 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2543 0 obj << /Alt () /K [ 97 ] /P 2435 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 2544 0 obj << /Obj 226 0 R /Pg 80 0 R /Type /OBJR >> endobj 2545 0 obj << /ActualText (5) /K [ 83 ] /P 2511 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2546 0 obj << /K [ 2547 0 R 2548 0 R 2549 0 R 2550 0 R 2551 0 R 2552 0 R 2553 0 R 2554 0 R 2555 0 R 2556 0 R 2557 0 R 2558 0 R ] /P 257 0 R /Pg 80 0 R /S /H2 /Type /StructElem >> endobj 2547 0 obj << /ActualText (3) /K [ 108 ] /P 2546 0 R /Pg 80 0 R /S /Span 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2702 0 R 2703 0 R 2704 0 R 2705 0 R 2706 0 R 2707 0 R ] /P 2693 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2696 0 obj << /K 237 /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2697 0 obj << /ActualText ( ) /K [ 238 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2698 0 obj << /ActualText (neighbours) /K [ 239 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2699 0 obj << /ActualText ( ) /K [ 240 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2700 0 obj << /ActualText (<= ) /K [ 241 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2701 0 obj << /ActualText (getNeighbours\() /K [ 242 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2702 0 obj << /ActualText (G) /K [ 243 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2703 0 obj << /ActualText (x) /K [ 244 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2704 0 obj << /ActualText (,) /K [ 245 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2705 0 obj << /ActualText (node1) /K [ 246 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2706 0 obj << /ActualText (\)) /K [ 247 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2707 0 obj << /ActualText ( ) /K [ 248 ] /P 2695 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2708 0 obj << /K [ 2709 0 R ] /P 2630 0 R /Pg 80 0 R /S /TR /Type /StructElem >> endobj 2709 0 obj << /K [ 2710 0 R 2711 0 R ] /P 2708 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2710 0 obj << /K 249 /P 2709 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2711 0 obj << /K [ 2712 0 R 2713 0 R 2714 0 R 2715 0 R 2716 0 R 2717 0 R 2718 0 R 2719 0 R 2720 0 R ] /P 2709 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2712 0 obj << /K 250 /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2713 0 obj << /ActualText ( ) /K [ 251 ] /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2714 0 obj << /ActualText (Sort) /K [ 252 ] /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2715 0 obj << /ActualText ( ) /K [ 253 ] /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2716 0 obj << /ActualText (neighbours ) /K [ 254 ] /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2717 0 obj << /ActualText (by their D) /K [ 255 ] /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2718 0 obj << /ActualText (-) /K [ 256 ] /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2719 0 obj << /ActualText (value) /K [ 257 ] /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2720 0 obj << /ActualText ( ) /K [ 258 ] /P 2711 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2721 0 obj << /K [ 2722 0 R ] /P 2630 0 R /Pg 80 0 R /S /TR /Type /StructElem >> endobj 2722 0 obj << /K [ 2723 0 R 2724 0 R ] /P 2721 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2723 0 obj << /K 259 /P 2722 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2724 0 obj << /K [ 2725 0 R 2726 0 R 2727 0 R 2728 0 R 2729 0 R 2730 0 R 2731 0 R 2732 0 R 2733 0 R 2734 0 R 2735 0 R 2736 0 R ] /P 2722 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2725 0 obj << /K 260 /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2726 0 obj << /ActualText ( ) /K [ 261 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2727 0 obj << /ActualText (foreach) /K [ 262 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2728 0 obj << /ActualText ( ) /K [ 263 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2729 0 obj << /ActualText (node2) /K [ 264 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2730 0 obj << /ActualText ( ) /K [ 265 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2731 0 obj << /ActualText (in) /K [ 266 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2732 0 obj << /ActualText ( ) /K [ 267 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2733 0 obj << /ActualText (neighbours) /K [ 268 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2734 0 obj << /ActualText ( ) /K [ 269 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2735 0 obj << /ActualText (do) /K [ 270 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2736 0 obj << /ActualText ( ) /K [ 271 ] /P 2724 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2737 0 obj << /K 272 /P 2738 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2738 0 obj << /K [ 2737 0 R 2739 0 R 2753 0 R 2762 0 R 2763 0 R ] /P 2760 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2739 0 obj << /K [ 2740 0 R 2741 0 R 2742 0 R 2743 0 R 2744 0 R 2745 0 R 2746 0 R 2747 0 R 2748 0 R 2749 0 R 2750 0 R 2751 0 R ] /P 2738 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2740 0 obj << /K 273 /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2741 0 obj << /ActualText ( ) /K [ 274 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2742 0 obj << /ActualText ( ) /K [ 275 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2743 0 obj << /ActualText (deleteEdge\() /K [ 276 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2744 0 obj << /ActualText (G) /K [ 277 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2745 0 obj << /ActualText (x) /K [ 278 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2746 0 obj << /ActualText (,) /K [ 279 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2747 0 obj << /ActualText (node1) /K [ 280 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2748 0 obj << /ActualText (,) /K [ 281 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2749 0 obj << /ActualText (node2) /K [ 282 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2750 0 obj << /ActualText (\)) /K [ 283 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2751 0 obj << /ActualText ( ) /K [ 284 ] /P 2739 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2752 0 obj << /K 285 /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2753 0 obj << /K [ 2752 0 R 2754 0 R 2755 0 R 2756 0 R 2757 0 R 2758 0 R 2759 0 R 2764 0 R 2765 0 R 2766 0 R ] /P 2738 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2754 0 obj << /ActualText ( ) /K [ 286 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2755 0 obj << /ActualText ( ) /K [ 287 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2756 0 obj << /ActualText (if ) /K [ 288 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2757 0 obj << /ActualText (notConnected\() /K [ 289 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2758 0 obj << /ActualText (Diff) /K [ 290 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2759 0 obj << /ActualText (\)) /K [ 291 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2760 0 obj << /K [ 2738 0 R ] /P 2630 0 R /Pg 80 0 R /S /TR /Type /StructElem >> endobj 2761 0 obj << /K [ 2784 0 R 2785 0 R ] /P 2630 0 R /Pg 80 0 R /S /TR /Type /StructElem >> endobj 2762 0 obj << /K [ 2767 0 R 2768 0 R 2769 0 R 2770 0 R 2771 0 R 2772 0 R 2773 0 R 2774 0 R 2775 0 R 2776 0 R 2777 0 R 2778 0 R 2779 0 R ] /P 2738 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2763 0 obj << /K [ 2780 0 R 2781 0 R 2782 0 R 2783 0 R ] /P 2738 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2764 0 obj << /ActualText ( ) /K [ 292 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2765 0 obj << /ActualText (then) /K [ 293 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2766 0 obj << /ActualText ( ) /K [ 294 ] /P 2753 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2767 0 obj << /K 295 /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2768 0 obj << /ActualText ( ) /K [ 296 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2769 0 obj << /ActualText ( ) /K [ 297 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2770 0 obj << /ActualText ( ) /K [ 298 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2771 0 obj << /ActualText (addEdge\() /K [ 299 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2772 0 obj << /ActualText (G) /K [ 300 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2773 0 obj << /ActualText (x) /K [ 301 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2774 0 obj << /ActualText (,) /K [ 302 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2775 0 obj << /ActualText (node1) /K [ 303 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2776 0 obj << /ActualText (,) /K [ 304 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2777 0 obj << /ActualText (node2) /K [ 305 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2778 0 obj << /ActualText (\)) /K [ 306 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2779 0 obj << /ActualText ( ) /K [ 307 ] /P 2762 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2780 0 obj << /K 308 /P 2763 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2781 0 obj << /ActualText ( ) /K [ 309 ] /P 2763 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2782 0 obj << /ActualText (end) /K [ 310 ] /P 2763 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2783 0 obj << /ActualText ( ) /K [ 311 ] /P 2763 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2784 0 obj << /K [ 2786 0 R 2787 0 R 2788 0 R 2789 0 R ] /P 2761 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2785 0 obj << /K 346 /P 2761 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2786 0 obj << /K 312 /P 2784 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2787 0 obj << /K [ 2790 0 R 2791 0 R 2792 0 R 2793 0 R ] /P 2784 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2788 0 obj << /K [ 2794 0 R 2795 0 R 2796 0 R 2797 0 R 2798 0 R 2799 0 R ] /P 2784 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2789 0 obj << /K [ 2800 0 R 2801 0 R 2802 0 R 2803 0 R 2804 0 R 2805 0 R 2806 0 R 2807 0 R 2808 0 R 2809 0 R 2810 0 R 2811 0 R 2812 0 R 2813 0 R 2814 0 R 2815 0 R 2816 0 R 2817 0 R 2818 0 R 2819 0 R 2820 0 R 2821 0 R 2822 0 R ] /P 2784 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2790 0 obj << /K 313 /P 2787 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2791 0 obj << /ActualText (e) /K [ 314 ] /P 2787 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2792 0 obj << /ActualText (nd) /K [ 315 ] /P 2787 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2793 0 obj << /ActualText ( ) /K [ 316 ] /P 2787 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2794 0 obj << /K 317 /P 2788 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2795 0 obj << /ActualText (deleteIsolatedNodes\() /K [ 318 ] /P 2788 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2796 0 obj << /ActualText (G) /K [ 319 ] /P 2788 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2797 0 obj << /ActualText (x) /K [ 320 ] /P 2788 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2798 0 obj << /ActualText (\)) /K [ 321 ] /P 2788 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2799 0 obj << /ActualText ( ) /K [ 322 ] /P 2788 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2800 0 obj << /K 323 /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2801 0 obj << /ActualText (KDS) /K [ 324 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2802 0 obj << /ActualText ( ) /K [ 325 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2803 0 obj << /ActualText (<= Subnet\() /K [ 326 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2804 0 obj << /ActualText (G) /K [ 327 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2805 0 obj << /ActualText (, Nodes\() /K [ 328 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2806 0 obj << /ActualText (G) /K [ 329 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2807 0 obj << /ActualText (x) /K [ 330 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2808 0 obj << /ActualText (\)\) /*) /K [ 331 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2809 0 obj << /ActualText ( ) /K [ 332 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2810 0 obj << /ActualText (get subnet ) /K [ 333 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2811 0 obj << /ActualText (KDS ) /K [ 334 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2812 0 obj << /ActualText (of ) /K [ 335 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2813 0 obj << /ActualText (left ) /K [ 336 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2814 0 obj << /ActualText (nodes in ) /K [ 337 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2815 0 obj << /ActualText (G) /K [ 338 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2816 0 obj << /ActualText (x) /K [ 339 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2817 0 obj << /ActualText ( ) /K [ 340 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2818 0 obj << /ActualText (from ) /K [ 341 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2819 0 obj << /ActualText (G) /K [ 342 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2820 0 obj << /ActualText ( ) /K [ 343 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2821 0 obj << /ActualText (*/) /K [ 344 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2822 0 obj << /ActualText ( ) /K [ 345 ] /P 2789 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2823 0 obj << /K [ 2824 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2824 0 obj << /ActualText ( ) /K [ 347 ] /P 2823 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2825 0 obj << /K [ 2826 0 R 2827 0 R 2828 0 R 2829 0 R 2830 0 R 2831 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2826 0 obj << /ActualText (Here, we illustrate the process of KDS abstraction as a toy example. Suppose there are 5 nodes in ) /K [ 348 ] /P 2825 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2827 0 obj << /ActualText (the original network G and G* as shown in Fig. 4. The hypothetical D) /K [ 349 ] /P 2825 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2828 0 obj << /ActualText (-) /K [ 350 ] /P 2825 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2829 0 obj << /ActualText (values of these 5 pairs of nodes ) /K [ 351 ] /P 2825 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2830 0 obj << /ActualText (are listed in Table 1.) /K [ 352 ] /P 2825 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2831 0 obj << /ActualText ( ) /K [ 353 ] /P 2825 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2832 0 obj << /K [ 2833 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2833 0 obj << /ActualText ( ) /K [ 354 ] /P 2832 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2834 0 obj << /K [ 528 ] /P 257 0 R /Pg 80 0 R /S /Figure /Type /StructElem >> endobj 2835 0 obj << /K [ 2836 0 R 2837 0 R 2838 0 R 2839 0 R 2840 0 R 2841 0 R 2842 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2836 0 obj << /ActualText (Fig. 4. ) /K [ 355 ] /P 2835 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2837 0 obj << /ActualText (Toy example of the networks G and G*. The red nodes represent the nodes in ) /K [ 356 ] /P 2835 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2838 0 obj << /ActualText (Diff) /K [ 357 ] /P 2835 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2839 0 obj << /ActualText (, whereas the blue nodes are not in ) /K [ 358 ] /P 2835 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2840 0 obj << /ActualText (Diff) /K [ 359 ] /P 2835 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2841 0 obj << /ActualText (.) /K [ 360 ] /P 2835 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2842 0 obj << /ActualText ( ) /K [ 361 ] /P 2835 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2843 0 obj << /K [ 2844 0 R 2845 0 R 2846 0 R 2847 0 R 2848 0 R 2849 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2844 0 obj << /ActualText (Table 1) /K [ 362 ] /P 2843 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2845 0 obj << /ActualText ( ) /K [ 363 ] /P 2843 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2846 0 obj << /ActualText (Hypothetical D) /K [ 364 ] /P 2843 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2847 0 obj << /ActualText (-) /K [ 365 ] /P 2843 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2848 0 obj << /ActualText (values of the 5 pairs of nodes between G and G*) /K [ 366 ] /P 2843 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2849 0 obj << /ActualText ( ) /K [ 367 ] /P 2843 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2850 0 obj << /K [ 2851 0 R 2852 0 R 2853 0 R ] /P 257 0 R /Pg 80 0 R /S /Table /Type /StructElem >> endobj 2851 0 obj << /K [ 2854 0 R 2855 0 R 2856 0 R 2857 0 R 2858 0 R 2859 0 R ] /P 2850 0 R /Pg 80 0 R /S /TR /Type /StructElem >> endobj 2852 0 obj << /K [ 2878 0 R 2879 0 R 2880 0 R 2881 0 R 2882 0 R 2883 0 R ] /P 2850 0 R /Pg 80 0 R /S /TR /Type /StructElem >> endobj 2853 0 obj << /K [ 2920 0 R 2921 0 R 2922 0 R 2923 0 R 2924 0 R 2925 0 R ] /P 2850 0 R /Pg 80 0 R /S /TR /Type /StructElem >> endobj 2854 0 obj << /K [ 2860 0 R ] /P 2851 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2855 0 obj << /K [ 2863 0 R ] /P 2851 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2856 0 obj << /K [ 2866 0 R ] /P 2851 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2857 0 obj << /K [ 2869 0 R ] /P 2851 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2858 0 obj << /K [ 2872 0 R ] /P 2851 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2859 0 obj << /K [ 2875 0 R ] /P 2851 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2860 0 obj << /K [ 2861 0 R 2862 0 R ] /P 2854 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2861 0 obj << /ActualText (Nodes in G) /K [ 368 ] /P 2860 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2862 0 obj << /ActualText ( ) /K [ 369 ] /P 2860 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2863 0 obj << /K [ 2864 0 R 2865 0 R ] /P 2855 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2864 0 obj << /ActualText (A) /K [ 370 ] /P 2863 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2865 0 obj << /ActualText ( ) /K [ 371 ] /P 2863 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2866 0 obj << /K [ 2867 0 R 2868 0 R ] /P 2856 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2867 0 obj << /ActualText (D) /K [ 372 ] /P 2866 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2868 0 obj << /ActualText ( ) /K [ 373 ] /P 2866 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2869 0 obj << /K [ 2870 0 R 2871 0 R ] /P 2857 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2870 0 obj << /ActualText (E) /K [ 374 ] /P 2869 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2871 0 obj << /ActualText ( ) /K [ 375 ] /P 2869 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2872 0 obj << /K [ 2873 0 R 2874 0 R ] /P 2858 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2873 0 obj << /ActualText (B) /K [ 376 ] /P 2872 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2874 0 obj << /ActualText ( ) /K [ 377 ] /P 2872 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2875 0 obj << /K [ 2876 0 R 2877 0 R ] /P 2859 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2876 0 obj << /ActualText (C) /K [ 378 ] /P 2875 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2877 0 obj << /ActualText ( ) /K [ 379 ] /P 2875 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2878 0 obj << /K [ 2884 0 R 2885 0 R ] /P 2852 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2879 0 obj << /K [ 2889 0 R 2890 0 R ] /P 2852 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2880 0 obj << /K [ 2896 0 R 2897 0 R ] /P 2852 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2881 0 obj << /K [ 2902 0 R 2903 0 R ] /P 2852 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2882 0 obj << /K [ 2908 0 R 2909 0 R ] /P 2852 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2883 0 obj << /K [ 2914 0 R 2915 0 R ] /P 2852 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2884 0 obj << /K 380 /P 2878 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2885 0 obj << /K [ 2886 0 R 2887 0 R 2888 0 R ] /P 2878 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2886 0 obj << /K 381 /P 2885 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2887 0 obj << /ActualText (Nodes in G*) /K [ 382 ] /P 2885 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2888 0 obj << /ActualText ( ) /K [ 383 ] /P 2885 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2889 0 obj << /K 384 /P 2879 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2890 0 obj << /K [ 2891 0 R 2892 0 R 2893 0 R 2894 0 R 2895 0 R ] /P 2879 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2891 0 obj << /K 385 /P 2890 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2892 0 obj << /ActualText (A) /K [ 386 ] /P 2890 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2893 0 obj << /ActualText ( ) /K [ 387 ] /P 2890 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2894 0 obj << /ActualText (') /K [ 388 ] /P 2890 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2895 0 obj << /ActualText ( ) /K [ 389 ] /P 2890 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2896 0 obj << /K 390 /P 2880 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2897 0 obj << /K [ 2898 0 R 2899 0 R 2900 0 R 2901 0 R ] /P 2880 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2898 0 obj << /K 391 /P 2897 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2899 0 obj << /ActualText (D) /K [ 392 ] /P 2897 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2900 0 obj << /ActualText (') /K [ 393 ] /P 2897 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2901 0 obj << /ActualText ( ) /K [ 394 ] /P 2897 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2902 0 obj << /K 395 /P 2881 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2903 0 obj << /K [ 2904 0 R 2905 0 R 2906 0 R 2907 0 R ] /P 2881 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2904 0 obj << /K 396 /P 2903 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2905 0 obj << /ActualText (E) /K [ 397 ] /P 2903 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2906 0 obj << /ActualText (') /K [ 398 ] /P 2903 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2907 0 obj << /ActualText ( ) /K [ 399 ] /P 2903 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2908 0 obj << /K 400 /P 2882 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2909 0 obj << /K [ 2910 0 R 2911 0 R 2912 0 R 2913 0 R ] /P 2882 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2910 0 obj << /K 401 /P 2909 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2911 0 obj << /ActualText (H) /K [ 402 ] /P 2909 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2912 0 obj << /ActualText (') /K [ 403 ] /P 2909 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2913 0 obj << /ActualText ( ) /K [ 404 ] /P 2909 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2914 0 obj << /K 405 /P 2883 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2915 0 obj << /K [ 2916 0 R 2917 0 R 2918 0 R 2919 0 R ] /P 2883 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2916 0 obj << /K 406 /P 2915 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2917 0 obj << /ActualText (F) /K [ 407 ] /P 2915 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2918 0 obj << /ActualText (') /K [ 408 ] /P 2915 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2919 0 obj << /ActualText ( ) /K [ 409 ] /P 2915 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2920 0 obj << /K [ 2926 0 R ] /P 2853 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2921 0 obj << /K [ 2931 0 R ] /P 2853 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2922 0 obj << /K [ 2934 0 R ] /P 2853 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2923 0 obj << /K [ 2937 0 R ] /P 2853 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2924 0 obj << /K [ 2940 0 R ] /P 2853 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2925 0 obj << /K [ 2943 0 R ] /P 2853 0 R /Pg 80 0 R /S /TD /Type /StructElem >> endobj 2926 0 obj << /K [ 2927 0 R 2928 0 R 2929 0 R 2930 0 R ] /P 2920 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2927 0 obj << /ActualText (D) /K [ 410 ] /P 2926 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2928 0 obj << /ActualText (-) /K [ 411 ] /P 2926 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2929 0 obj << /ActualText (value) /K [ 412 ] /P 2926 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2930 0 obj << /ActualText ( ) /K [ 413 ] /P 2926 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2931 0 obj << /K [ 2932 0 R 2933 0 R ] /P 2921 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2932 0 obj << /ActualText (0.70) /K [ 414 ] /P 2931 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2933 0 obj << /ActualText ( ) /K [ 415 ] /P 2931 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2934 0 obj << /K [ 2935 0 R 2936 0 R ] /P 2922 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2935 0 obj << /ActualText (0.50) /K [ 416 ] /P 2934 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2936 0 obj << /ActualText ( ) /K [ 417 ] /P 2934 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2937 0 obj << /K [ 2938 0 R 2939 0 R ] /P 2923 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2938 0 obj << /ActualText (0.45) /K [ 418 ] /P 2937 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2939 0 obj << /ActualText ( ) /K [ 419 ] /P 2937 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2940 0 obj << /K [ 2941 0 R 2942 0 R ] /P 2924 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2941 0 obj << /ActualText (0.35) /K [ 420 ] /P 2940 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2942 0 obj << /ActualText ( ) /K [ 421 ] /P 2940 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2943 0 obj << /K [ 2944 0 R 2945 0 R ] /P 2925 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2944 0 obj << /ActualText (0.28) /K [ 422 ] /P 2943 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2945 0 obj << /ActualText ( ) /K [ 423 ] /P 2943 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2946 0 obj << /K [ 2947 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2947 0 obj << /ActualText ( ) /K [ 424 ] /P 2946 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2948 0 obj << /K [ 2949 0 R 2950 0 R 2951 0 R 2952 0 R 2953 0 R 2954 0 R 2955 0 R 2956 0 R 2957 0 R 2958 0 R 2959 0 R 2960 0 R 2961 0 R 2962 0 R 2963 0 R 2964 0 R 2965 0 R 2966 0 R 2967 0 R 2968 0 R 2969 0 R 2970 0 R 2971 0 R 2972 0 R 2973 0 R 2974 0 R 2975 0 R 2976 0 R 2977 0 R 2978 0 R 2979 0 R 2980 0 R 2981 0 R 2982 0 R 2983 0 R 2984 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2949 0 obj << /ActualText (According to the steps outlined in algorithm 1, the removal order of these edges in G is \() /K [ 425 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2950 0 obj << /ActualText (E) /K [ 426 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2951 0 obj << /ActualText (,) /K [ 427 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2952 0 obj << /ActualText ( ) /K [ 428 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2953 0 obj << /ActualText (B) /K [ 429 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2954 0 obj << /ActualText (\)) /K [ 430 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2955 0 obj << /ActualText (-) /K [ 431 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2956 0 obj << /ActualText (> \() /K [ 432 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2957 0 obj << /ActualText (A) /K [ 433 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2958 0 obj << /ActualText (, ) /K [ 434 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2959 0 obj << /ActualText (B) /K [ 435 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2960 0 obj << /ActualText (\) ) /K [ 436 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2961 0 obj << /ActualText (and in G* it is \() /K [ 437 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2962 0 obj << /ActualText (E) /K [ 438 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2963 0 obj << /ActualText (') /K [ 439 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2964 0 obj << /ActualText (,) /K [ 440 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2965 0 obj << /ActualText ( ) /K [ 441 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2966 0 obj << /ActualText (F) /K [ 442 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2967 0 obj << /ActualText (') /K [ 443 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2968 0 obj << /ActualText (\) ) /K [ 444 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2969 0 obj << /ActualText (-) /K [ 445 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2970 0 obj << /ActualText (> \(E) /K [ 446 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2971 0 obj << /ActualText (') /K [ 447 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2972 0 obj << /ActualText (, H) /K [ 448 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2973 0 obj << /ActualText (') /K [ 449 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2974 0 obj << /ActualText (\)) /K [ 450 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2975 0 obj << /ActualText (-) /K [ 451 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2976 0 obj << /ActualText (> \() /K [ 452 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2977 0 obj << /ActualText (D) /K [ 453 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2978 0 obj << /ActualText (') /K [ 454 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2979 0 obj << /ActualText (, ) /K [ 455 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2980 0 obj << /ActualText (F) /K [ 456 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2981 0 obj << /ActualText (') /K [ 457 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2982 0 obj << /ActualText (\). Therefore, the final results of the KDS in G and G* are as ) /K [ 458 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2983 0 obj << /ActualText (shown in Fig. 5.) /K [ 459 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2984 0 obj << /ActualText ( ) /K [ 460 ] /P 2948 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2985 0 obj << /K [ 2986 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2986 0 obj << /ActualText ( ) /K [ 461 ] /P 2985 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2987 0 obj << /K [ 529 ] /P 257 0 R /Pg 80 0 R /S /Figure /Type /StructElem >> endobj 2988 0 obj << /K [ 2989 0 R 2990 0 R 2991 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2989 0 obj << /ActualText (Fig. 5. ) /K [ 462 ] /P 2988 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2990 0 obj << /ActualText (KDS of G and G* of the toy example.) /K [ 463 ] /P 2988 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2991 0 obj << /ActualText ( ) /K [ 464 ] /P 2988 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2992 0 obj << /K [ 2993 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2993 0 obj << /ActualText ( ) /K [ 465 ] /P 2992 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2994 0 obj << /K [ 2995 0 R 2996 0 R 2997 0 R 2998 0 R 2999 0 R 3000 0 R 3001 0 R 3002 0 R 3003 0 R 3004 0 R 3005 0 R 3006 0 R 3007 0 R 3008 0 R 3009 0 R 3010 0 R 3011 0 R 3012 0 R 3013 0 R 3014 0 R 3015 0 R 3016 0 R 3017 0 R 3018 0 R 3019 0 R 3020 0 R 3021 0 R 3022 0 R 3023 0 R 3024 0 R 3025 0 R 3026 0 R 3027 0 R 3028 0 R 3029 0 R 3030 0 R 3031 0 R 3032 0 R 3033 0 R 3034 0 R 3035 0 R 3036 0 R 3037 0 R 3038 0 R 3039 0 R 3040 0 R 3041 0 R 3042 0 R 3043 0 R 3044 0 R 3045 0 R 3046 0 R 3047 0 R 3048 0 R 3049 0 R 3050 0 R 3051 0 R 3052 0 R 3053 0 R 3054 0 R 3055 0 R 3056 0 R 3057 0 R ] /P 257 0 R /Pg 80 0 R /S /P /Type /StructElem >> endobj 2995 0 obj << /ActualText (Finally, the) /K [ 466 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2996 0 obj << /ActualText ( ) /K [ 467 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2997 0 obj << /ActualText (KDS) /K [ 468 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2998 0 obj << /ActualText ( ) /K [ 469 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 2999 0 obj << /ActualText (of) /K [ 470 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3000 0 obj << /ActualText ( ) /K [ 471 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3001 0 obj << /ActualText ( ) /K [ 473 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3002 0 obj << /ActualText (was obtained,) /K [ 474 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3003 0 obj << /ActualText ( ) /K [ 475 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3004 0 obj << /ActualText (which) /K [ 476 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3005 0 obj << /ActualText ( ) /K [ 477 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3006 0 obj << /ActualText (includ) /K [ 478 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3007 0 obj << /ActualText (e) /K [ 479 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3008 0 obj << /ActualText (s) /K [ 480 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3009 0 obj << /ActualText ( ) /K [ 481 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3010 0 obj << /ActualText (the ) /K [ 482 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3011 0 obj << /ActualText (differential ) /K [ 483 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3012 0 obj << /ActualText (nodes) /K [ 484 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3013 0 obj << /ActualText ( ) /K [ 485 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3014 0 obj << /ActualText (. ) /K [ 486 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3015 0 obj << /ActualText (T) /K [ 487 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3016 0 obj << /ActualText (o further ) /K [ 488 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3017 0 obj << /ActualText (determine ) /K [ 489 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3018 0 obj << /ActualText (the ) /K [ 490 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3019 0 obj << /ActualText (dissimilarity) /K [ 491 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3020 0 obj << /ActualText ( ) /K [ 492 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3021 0 obj << /ActualText (between ) /K [ 493 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3022 0 obj << /ActualText (the two ) /K [ 494 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3023 0 obj << /ActualText (KDS) /K [ 495 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3024 0 obj << /ActualText (s) /K [ 496 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3025 0 obj << /ActualText (, we compute the PE and ) /K [ 497 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3026 0 obj << /ActualText (EC score) /K [ 498 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3027 0 obj << /ActualText (s) /K [ 499 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3028 0 obj << /ActualText (.) /K [ 500 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3029 0 obj << /ActualText ( ) /K [ 501 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3030 0 obj << /ActualText (In this ) /K [ 502 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3031 0 obj << /ActualText (study) /K [ 503 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3032 0 obj << /ActualText (, ) /K [ 504 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3033 0 obj << /ActualText (we) /K [ 505 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3034 0 obj << /ActualText ( ) /K [ 506 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3035 0 obj << /ActualText (also ) /K [ 507 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3036 0 obj << /ActualText (evaluate) /K [ 508 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3037 0 obj << /ActualText (d) /K [ 509 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3038 0 obj << /ActualText ( ) /K [ 510 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3039 0 obj << /ActualText (the) /K [ 511 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3040 0 obj << /ActualText ( ) /K [ 512 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3041 0 obj << /ActualText (p) /K [ 513 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3042 0 obj << /ActualText (-) /K [ 514 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3043 0 obj << /ActualText (value) /K [ 515 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3044 0 obj << /ActualText (s) /K [ 516 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3045 0 obj << /ActualText ( ) /K [ 517 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3046 0 obj << /ActualText (of PE and EC ) /K [ 518 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3047 0 obj << /ActualText (in a ) /K [ 519 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3048 0 obj << /ActualText (KDS with 100) /K [ 520 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3049 0 obj << /ActualText (-) /K [ 521 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3050 0 obj << /ActualText (time random result) /K [ 522 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3051 0 obj << /ActualText (s) /K [ 523 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3052 0 obj << /ActualText (.) /K [ 524 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3053 0 obj << /ActualText ( ) /K [ 525 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3054 0 obj << /ActualText (The ) /K [ 526 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3055 0 obj << /ActualText (random connected ) /K [ 527 ] /P 2994 0 R /Pg 80 0 R /S /Span /Type /StructElem >> endobj 3056 0 obj << /Alt () /K [ 472 ] /P 2994 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 3057 0 obj << /Alt () /K [ ] /P 2994 0 R /Pg 80 0 R /S /InlineShape /Type /StructElem >> endobj 3058 0 obj << /K [ 3059 0 R 3060 0 R 3061 0 R 3062 0 R 3063 0 R 3064 0 R 3065 0 R 3066 0 R 3067 0 R 3068 0 R 3069 0 R 3070 0 R 3071 0 R 3072 0 R 3073 0 R 3074 0 R 3075 0 R 3076 0 R 3077 0 R 3078 0 R 3079 0 R 3080 0 R 3081 0 R 3082 0 R 3083 0 R 3084 0 R 3085 0 R 3086 0 R 3087 0 R 3088 0 R 3089 0 R 3090 0 R 3091 0 R 3092 0 R 3093 0 R 3094 0 R 3095 0 R 3096 0 R 3097 0 R 3098 0 R 3099 0 R 3100 0 R 3101 0 R 3102 0 R 3103 0 R 3104 0 R 3105 0 R 3106 0 R 3107 0 R 3108 0 R 3109 0 R 3110 0 R 3111 0 R 3112 0 R 3113 0 R 3114 0 R ] /P 257 0 R /Pg 98 0 R /S /P /Type /StructElem >> endobj 3059 0 obj << /ActualText (subnet ) /K [ 0 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3060 0 obj << /ActualText (was ) /K [ 1 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3061 0 obj << /ActualText (generated ) /K [ 2 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3062 0 obj << /ActualText (using ) /K [ 3 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3063 0 obj << /ActualText (a specified number of ) /K [ 4 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3064 0 obj << /ActualText (gene) /K [ 5 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3065 0 obj << /ActualText (s. ) /K [ 6 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3066 0 obj << /ActualText (The v) /K [ 7 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3067 0 obj << /ActualText (alidati) /K [ 8 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3068 0 obj << /ActualText (on of) /K [ 9 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3069 0 obj << /ActualText ( ) /K [ 10 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3070 0 obj << /ActualText (the ) /K [ 11 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3071 0 obj << /ActualText (dissimilarity) /K [ 12 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3072 0 obj << /ActualText ( ) /K [ 13 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3073 0 obj << /ActualText (between ) /K [ 14 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3074 0 obj << /ActualText (the ) /K [ 15 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3075 0 obj << /ActualText (result) /K [ 16 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3076 0 obj << /ActualText (s) /K [ 17 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3077 0 obj << /ActualText ( ) /K [ 18 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3078 0 obj << /ActualText (produced by ) /K [ 19 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3079 0 obj << /ActualText (the ) /K [ 20 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3080 0 obj << /ActualText (TKDS) /K [ 21 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3081 0 obj << /ActualText ( ) /K [ 22 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3082 0 obj << /ActualText (algorithm ) /K [ 23 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3083 0 obj << /ActualText (and ) /K [ 24 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3084 0 obj << /ActualText (random results is a ) /K [ 25 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3085 0 obj << /ActualText (frequent) /K [ 26 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3086 0 obj << /ActualText (ly ) /K [ 27 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3087 0 obj << /ActualText (used ) /K [ 28 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3088 0 obj << /ActualText (statistical method.) /K [ 29 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3089 0 obj << /ActualText ( ) /K [ 30 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3090 0 obj << /ActualText (This ) /K [ 31 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3091 0 obj << /ActualText (dissimilarity) /K [ 32 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3092 0 obj << /ActualText ( ) /K [ 33 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3093 0 obj << /ActualText (is characterized by) /K [ 34 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3094 0 obj << /ActualText ( ) /K [ 35 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3095 0 obj << /ActualText (the) /K [ 36 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3096 0 obj << /ActualText ( ) /K [ 37 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3097 0 obj << /ActualText (p) /K [ 38 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3098 0 obj << /ActualText (-) /K [ 39 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3099 0 obj << /ActualText (value.) /K [ 40 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3100 0 obj << /ActualText ( ) /K [ 41 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3101 0 obj << /ActualText (The smaller the ) /K [ 42 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3102 0 obj << /ActualText (p) /K [ 43 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3103 0 obj << /ActualText (-) /K [ 44 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3104 0 obj << /ActualText (value) /K [ 45 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3105 0 obj << /ActualText ( ) /K [ 46 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3106 0 obj << /ActualText (is) /K [ 47 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3107 0 obj << /ActualText (, the more reliable) /K [ 48 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3108 0 obj << /ActualText ( ) /K [ 49 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3109 0 obj << /ActualText (the result) /K [ 50 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3110 0 obj << /ActualText ( ) /K [ 51 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3111 0 obj << /ActualText (is) /K [ 52 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3112 0 obj << /ActualText (.) /K [ 53 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3113 0 obj << /ActualText ( ) /K [ 54 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3114 0 obj << /ActualText ( ) /K [ 55 ] /P 3058 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3115 0 obj << /K [ 3116 0 R 3117 0 R 3118 0 R 3119 0 R ] /P 257 0 R /Pg 98 0 R /S /H1 /Type /StructElem >> endobj 3116 0 obj << /ActualText (4) /K [ 56 ] /P 3115 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3117 0 obj << /ActualText ( ) /K [ 57 ] /P 3115 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3118 0 obj << /ActualText (Experiments) /K [ 58 ] /P 3115 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3119 0 obj << /ActualText ( ) /K [ 59 ] /P 3115 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3120 0 obj << /K [ 3121 0 R 3122 0 R 3123 0 R 3124 0 R 3125 0 R 3126 0 R 3127 0 R ] /P 257 0 R /Pg 98 0 R /S /H2 /Type /StructElem >> endobj 3121 0 obj << /ActualText (4) /K [ 60 ] /P 3120 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3122 0 obj << /ActualText (.1) /K [ 61 ] /P 3120 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3123 0 obj << /ActualText ( ) /K [ 62 ] /P 3120 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3124 0 obj << /ActualText (Dataset and ) /K [ 63 ] /P 3120 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3125 0 obj << /ActualText (a ) /K [ 64 ] /P 3120 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3126 0 obj << /ActualText (priori knowledge) /K [ 65 ] /P 3120 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3127 0 obj << /ActualText ( ) /K [ 66 ] /P 3120 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3128 0 obj << /K [ 3129 0 R 3130 0 R 3131 0 R 3132 0 R 3133 0 R 3134 0 R 3135 0 R 3136 0 R 3137 0 R 3138 0 R 3139 0 R 3140 0 R 3141 0 R 3142 0 R 3143 0 R 3144 0 R 3145 0 R 3146 0 R 3147 0 R 3148 0 R 3149 0 R 3150 0 R 3151 0 R 3152 0 R 3153 0 R 3154 0 R 3155 0 R 3156 0 R 3157 0 R ] /P 257 0 R /Pg 98 0 R /S /P /Type /StructElem >> endobj 3129 0 obj << /ActualText ( ) /K [ 67 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3130 0 obj << /ActualText (A classic ) /K [ 68 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3131 0 obj << /ActualText (dataset was used in this work to analyse the molecular signature of non) /K [ 69 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3132 0 obj << /ActualText (-) /K [ 70 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3133 0 obj << /ActualText (smoking females ) /K [ 71 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3134 0 obj << /ActualText (with NSCLC in Taiwan) /K [ 72 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3135 0 obj << /ActualText ([) /K [ 73 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3136 0 obj << /K [ 3158 0 R 3159 0 R ] /P 3128 0 R /Pg 98 0 R /S /Link /Type /StructElem >> endobj 3137 0 obj << /ActualText (]) /K [ 75 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3138 0 obj << /ActualText (. This dataset ) /K [ 76 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3139 0 obj << /ActualText (contains gene expression analyses ) /K [ 77 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3140 0 obj << /ActualText (of ) /K [ 78 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3141 0 obj << /ActualText (RNA extracted from ) /K [ 79 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3142 0 obj << /ActualText (paired tumour and normal tissues using the Affymetrix Human Genome U133 Plus 2.0 Array. ) /K [ 80 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3143 0 obj << /ActualText (The dataset ) /K [ 81 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3144 0 obj << /ActualText (includes) /K [ 82 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3145 0 obj << /ActualText ( ) /K [ 83 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3146 0 obj << /ActualText (60 cancerous samples and 60 normal samples. Only one pathway, i.e., hsa05223 in NSCLC of ) /K [ 84 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3147 0 obj << /ActualText (Ho) /K [ 85 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3148 0 obj << /ActualText (mo sapiens, is found in the KEGG database, and 58 genes are identified. The gene nucleotide ) /K [ 86 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3149 0 obj << /ActualText (sequences are retrieved from Ensembl using EMBL) /K [ 87 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3150 0 obj << /ActualText (-) /K [ 88 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3151 0 obj << /ActualText (EBI) /K [ 89 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3152 0 obj << /ActualText ([) /K [ 90 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3153 0 obj << /K [ 3160 0 R 3161 0 R ] /P 3128 0 R /Pg 98 0 R /S /Link /Type /StructElem >> endobj 3154 0 obj << /ActualText (]) /K [ 92 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3155 0 obj << /ActualText (, which freely provides abundant biological ) /K [ 93 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3156 0 obj << /ActualText (data and online services.) /K [ 94 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3157 0 obj << /ActualText ( ) /K [ 95 ] /P 3128 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3158 0 obj << /Obj 227 0 R /Pg 98 0 R /Type /OBJR >> endobj 3159 0 obj << /ActualText (19) /K [ 74 ] /P 3136 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3160 0 obj << /Obj 228 0 R /Pg 98 0 R /Type /OBJR >> endobj 3161 0 obj << /ActualText (20) /K [ 91 ] /P 3153 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3162 0 obj << /K [ 3163 0 R 3164 0 R 3165 0 R 3166 0 R 3167 0 R 3168 0 R ] /P 257 0 R /Pg 98 0 R /S /H2 /Type /StructElem >> endobj 3163 0 obj << /ActualText (4) /K [ 96 ] /P 3162 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3164 0 obj << /ActualText (.2) /K [ 97 ] /P 3162 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3165 0 obj << /ActualText ( ) /K [ 98 ] /P 3162 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3166 0 obj << /ActualText (Network ) /K [ 99 ] /P 3162 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3167 0 obj << /ActualText (construction and pairwise alignment) /K [ 100 ] /P 3162 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3168 0 obj << /ActualText ( ) /K [ 101 ] /P 3162 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3169 0 obj << /ActualText ( ) /K [ 102 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3170 0 obj << /K [ 3169 0 R 3171 0 R 3172 0 R 3173 0 R 3174 0 R 3175 0 R 3176 0 R 3177 0 R 3178 0 R 3179 0 R 3180 0 R 3181 0 R 3182 0 R 3183 0 R 3184 0 R 3185 0 R 3186 0 R 3187 0 R 3188 0 R 3189 0 R 3190 0 R 3191 0 R 3192 0 R 3193 0 R 3194 0 R 3195 0 R 3196 0 R 3197 0 R 3198 0 R 3199 0 R 3200 0 R 3201 0 R 3202 0 R 3203 0 R 3204 0 R 3205 0 R 3206 0 R 3207 0 R 3208 0 R 3209 0 R 3210 0 R 3211 0 R 3212 0 R 3213 0 R 3214 0 R 3215 0 R 3216 0 R 3217 0 R 3218 0 R 3219 0 R 3220 0 R 3221 0 R 3222 0 R 3223 0 R 3224 0 R 3225 0 R 3226 0 R 3227 0 R 3228 0 R 3229 0 R 3230 0 R 3231 0 R 3232 0 R 3233 0 R 3234 0 R 3235 0 R 3236 0 R 3237 0 R 3238 0 R 3239 0 R 3240 0 R 3241 0 R 3242 0 R 3243 0 R 3244 0 R 3245 0 R 3246 0 R 3247 0 R 3248 0 R 3249 0 R 3250 0 R 3251 0 R 3252 0 R 3253 0 R 3254 0 R 3255 0 R 3256 0 R 3257 0 R 3258 0 R 3259 0 R 3260 0 R 3261 0 R 3262 0 R 3263 0 R 3264 0 R 3265 0 R 3266 0 R 3267 0 R 3268 0 R 3269 0 R 3270 0 R 3271 0 R 3272 0 R 3273 0 R 3274 0 R 3275 0 R 3276 0 R 3277 0 R 3278 0 R 3279 0 R 3280 0 R 3281 0 R 3282 0 R 3283 0 R 3284 0 R 3285 0 R 3286 0 R 3287 0 R 3288 0 R 3289 0 R 3290 0 R 3291 0 R 3292 0 R 3293 0 R 3294 0 R 3295 0 R 3296 0 R 3297 0 R 3298 0 R 3299 0 R 3300 0 R 3301 0 R 3302 0 R 3303 0 R 3304 0 R 3305 0 R 3306 0 R 3307 0 R 3308 0 R 3309 0 R 3310 0 R 3311 0 R 3312 0 R 3313 0 R 3314 0 R 3315 0 R 3316 0 R 3317 0 R 3318 0 R 3319 0 R 3320 0 R 3321 0 R 3322 0 R 3323 0 R 3324 0 R 3325 0 R 3326 0 R 3327 0 R 3328 0 R 3329 0 R 3330 0 R 3331 0 R 3332 0 R 3333 0 R ] /P 257 0 R /Pg 98 0 R /S /P /Type /StructElem >> endobj 3171 0 obj << /ActualText (First) /K [ 103 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3172 0 obj << /ActualText (, we ) /K [ 104 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3173 0 obj << /ActualText (select) /K [ 105 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3174 0 obj << /ActualText (ed) /K [ 106 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3175 0 obj << /ActualText ( ) /K [ 107 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3176 0 obj << /ActualText (58 ) /K [ 108 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3177 0 obj << /ActualText (genes in) /K [ 109 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3178 0 obj << /ActualText ( ) /K [ 110 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3179 0 obj << /ActualText (the) /K [ 111 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3180 0 obj << /ActualText ( ) /K [ 112 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3181 0 obj << /ActualText (NS) /K [ 113 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3182 0 obj << /ActualText (C) /K [ 114 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3183 0 obj << /ActualText (LC) /K [ 115 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3184 0 obj << /ActualText (-) /K [ 116 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3185 0 obj << /ActualText (related ) /K [ 117 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3186 0 obj << /ActualText (pathway) /K [ 118 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3187 0 obj << /ActualText ( ) /K [ 119 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3188 0 obj << /ActualText (and ) /K [ 120 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3189 0 obj << /ActualText (other ) /K [ 121 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3190 0 obj << /ActualText (genes ) /K [ 122 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3191 0 obj << /ActualText (with) /K [ 123 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3192 0 obj << /ActualText ( ) /K [ 124 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3193 0 obj << /ActualText (strong Pearson ) /K [ 125 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3194 0 obj << /ActualText (correlations) /K [ 126 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3195 0 obj << /ActualText ( ) /K [ 127 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3196 0 obj << /ActualText (\() /K [ 128 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3197 0 obj << /ActualText (e.g., ) /K [ 129 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3198 0 obj << /ActualText (0.8) /K [ 130 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3199 0 obj << /ActualText ( ) /K [ 131 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3200 0 obj << /ActualText (or greater) /K [ 132 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3201 0 obj << /ActualText (\)) /K [ 133 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3202 0 obj << /ActualText ( ) /K [ 134 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3203 0 obj << /ActualText (according to) /K [ 135 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3204 0 obj << /ActualText ( ) /K [ 136 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3205 0 obj << /ActualText (the pre) /K [ 137 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3206 0 obj << /ActualText (-) /K [ 138 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3207 0 obj << /ActualText (processed gene expression matrix.) /K [ 139 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3208 0 obj << /ActualText ( ) /K [ 140 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3209 0 obj << /ActualText (Then) /K [ 141 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3210 0 obj << /ActualText (, 186 and ) /K [ 142 ] 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193 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3258 0 obj << /ActualText (,) /K [ 195 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3259 0 obj << /ActualText ( ) /K [ 196 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3260 0 obj << /ActualText (and ) /K [ 197 ] /P 3170 0 R /Pg 98 0 R /S /Span /Type /StructElem >> endobj 3261 0 obj << /ActualText (. 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/Pg 112 0 R /S /P /Type /StructElem >> endobj 4897 0 obj << /ActualText (The topology of the ) /K [ 206 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4898 0 obj << /ActualText (abovementioned) /K [ 207 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4899 0 obj << /ActualText ( ) /K [ 208 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4900 0 obj << /ActualText (genes has ) /K [ 209 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4901 0 obj << /ActualText (clearly ) /K [ 210 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4902 0 obj << /ActualText (changed) /K [ 211 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4903 0 obj << /ActualText (,) /K [ 212 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4904 0 obj << /ActualText ( ) /K [ 213 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4905 0 obj << /ActualText (which explain) /K [ 214 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4906 0 obj << /ActualText (s) /K [ 215 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4907 0 obj << /ActualText ( ) /K [ 216 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4908 0 obj << /ActualText (the ) /K [ 217 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4909 0 obj << /ActualText (importance ) /K [ 218 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4910 0 obj << /ActualText (of ) /K [ 219 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4911 0 obj << /ActualText (physical propert) /K [ 220 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4912 0 obj << /ActualText (ies) /K [ 221 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4913 0 obj << /ActualText (. In biology, genes ) /K [ 222 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4914 0 obj << /ActualText (execute their functions) /K [ 223 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4915 0 obj << /ActualText ( ) /K [ 224 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4916 0 obj << /ActualText (within ) /K [ 225 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4917 0 obj << /ActualText (interacting functional modules.) /K [ 226 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4918 0 obj << /ActualText ( ) /K [ 227 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4919 0 obj << /ActualText (Thus) /K [ 228 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4920 0 obj << /ActualText (, ) /K [ 229 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4921 0 obj << /ActualText (the ) /K [ 230 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4922 0 obj << /ActualText (TKDS) /K [ 231 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4923 0 obj << /ActualText ( ) /K [ 232 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4924 0 obj << /ActualText (extracts the ) /K [ 233 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4925 0 obj << /ActualText (KDS) /K [ 234 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4926 0 obj << /ActualText (s) /K [ 235 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4927 0 obj << /ActualText ( ) /K [ 236 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4928 0 obj << /ActualText ( ) /K [ 238 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4929 0 obj << /ActualText (and ) /K [ 239 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4930 0 obj << /ActualText ( ) /K [ 241 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4931 0 obj << /ActualText (of the 30 differential genes from the original network) /K [ 242 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4932 0 obj << /ActualText (s) /K [ 243 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4933 0 obj << /ActualText ( ) /K [ 244 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4934 0 obj << /ActualText ( ) /K [ 246 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4935 0 obj << /ActualText (and) /K [ 247 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4936 0 obj << /ActualText ( ) /K [ 248 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4937 0 obj << /ActualText (. The result) /K [ 250 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4938 0 obj << /ActualText (s) /K [ 251 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4939 0 obj << /ActualText ( ) /K [ 252 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4940 0 obj << /ActualText (are ) /K [ 253 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4941 0 obj << /ActualText (visualized ) /K [ 254 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4942 0 obj << /ActualText (using ) /K [ 255 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4943 0 obj << /ActualText (Gephi) /K [ 256 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4944 0 obj << /ActualText ([) /K [ 257 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4945 0 obj << /K [ 5036 0 R 5037 0 R ] /P 4896 0 R /Pg 112 0 R /S /Link /Type /StructElem >> endobj 4946 0 obj << /ActualText (]) /K [ 259 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4947 0 obj << /ActualText ( ) /K [ 260 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4948 0 obj << /ActualText (as ) /K [ 261 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4949 0 obj << /ActualText (shown in F) /K [ 262 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4950 0 obj << /ActualText (ig.) /K [ 263 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4951 0 obj << /ActualText ( ) /K [ 264 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4952 0 obj << /ActualText (6) /K [ 265 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4953 0 obj << /ActualText (:) /K [ 266 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4954 0 obj << /ActualText ( ) /K [ 267 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4955 0 obj << /ActualText (the) /K [ 268 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4956 0 obj << /ActualText ( ) /K [ 269 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4957 0 obj << /ActualText (blue nodes represent 30 ) /K [ 270 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4958 0 obj << /ActualText (genes that are ) /K [ 271 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4959 0 obj << /ActualText (common ) /K [ 272 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4960 0 obj << /ActualText (to ) /K [ 273 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4961 0 obj << /ActualText (both ) /K [ 274 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4962 0 obj << /ActualText (the ) /K [ 275 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4963 0 obj << /ActualText (cancer and normal state) /K [ 276 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4964 0 obj << /ActualText (s) /K [ 277 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4965 0 obj << /ActualText (,) /K [ 278 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4966 0 obj << /ActualText ( ) /K [ 279 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4967 0 obj << /ActualText (the) /K [ 280 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4968 0 obj << /ActualText ( ) /K [ 281 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4969 0 obj << /ActualText (red nodes ) /K [ 282 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4970 0 obj << /ActualText (represent ) /K [ 283 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4971 0 obj << /ActualText (the differential genes ) /K [ 284 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4972 0 obj << /ActualText (connect) /K [ 285 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4973 0 obj << /ActualText (ed) /K [ 286 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4974 0 obj << /ActualText ( ) /K [ 287 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4975 0 obj << /ActualText (to ) /K [ 288 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4976 0 obj << /ActualText (the) /K [ 289 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4977 0 obj << /ActualText ( ) /K [ 290 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4978 0 obj << /ActualText (30 genes ) /K [ 291 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4979 0 obj << /ActualText (represented in blue, ) /K [ 292 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4980 0 obj << /ActualText (the green nodes ) /K [ 293 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4981 0 obj << /ActualText (represent ) /K [ 294 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4982 0 obj << /ActualText (the common nodes added ) /K [ 295 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4983 0 obj << /ActualText (using) /K [ 296 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4984 0 obj << /ActualText ( ) /K [ 297 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4985 0 obj << /ActualText (the proposed method) /K [ 298 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4986 0 obj << /ActualText (, and the ) /K [ 299 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4987 0 obj << /ActualText (small ) /K [ 300 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4988 0 obj << /ActualText (black nodes are the ordinary genes ) /K [ 301 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4989 0 obj << /ActualText (that do not exist in) /K [ 302 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4990 0 obj << /ActualText ( ) /K [ 303 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4991 0 obj << /ActualText (the KDS) /K [ 304 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4992 0 obj << /ActualText (.) /K [ 305 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4993 0 obj << /ActualText ( ) /K [ 306 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4994 0 obj << /ActualText (A) /K [ 307 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4995 0 obj << /ActualText ( ) /K [ 308 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4996 0 obj << /ActualText (and) /K [ 309 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4997 0 obj << /ActualText ( ) /K [ 310 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4998 0 obj << /ActualText (B ) /K [ 311 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 4999 0 obj << /ActualText (represent ) /K [ 312 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5000 0 obj << /ActualText (the overall network) /K [ 313 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5001 0 obj << /ActualText (,) /K [ 314 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5002 0 obj << /ActualText ( ) /K [ 315 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5003 0 obj << /ActualText (and C) /K [ 316 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5004 0 obj << /ActualText ( ) /K [ 317 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5005 0 obj << /ActualText (and) /K [ 318 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5006 0 obj << /ActualText ( ) /K [ 319 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5007 0 obj << /ActualText (D are the) /K [ 320 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5008 0 obj << /ActualText ( ) /K [ 321 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5009 0 obj << /ActualText (two ) /K [ 322 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5010 0 obj << /ActualText (extract) /K [ 323 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5011 0 obj << /ActualText (ed) /K [ 324 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5012 0 obj << /ActualText ( ) /K [ 325 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5013 0 obj << /ActualText (KDS) /K [ 326 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5014 0 obj << /ActualText (s) /K [ 327 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5015 0 obj << /ActualText ( ) /K [ 328 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5016 0 obj << /ActualText (in ) /K [ 329 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5017 0 obj << /ActualText (the ) /K [ 330 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5018 0 obj << /ActualText (cancer and normal ) /K [ 331 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5019 0 obj << /ActualText (states) /K [ 332 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5020 0 obj << /ActualText (,) /K [ 333 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5021 0 obj << /ActualText ( ) /K [ 334 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5022 0 obj << /ActualText (provid) /K [ 335 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5023 0 obj << /ActualText (ing ) /K [ 336 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5024 0 obj << /ActualText (a more distinct visual) /K [ 337 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5025 0 obj << /ActualText (ization) /K [ 338 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5026 0 obj << /ActualText (.) /K [ 339 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5027 0 obj << /ActualText ( ) /K [ 340 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5028 0 obj << /ActualText (E) /K [ 341 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5029 0 obj << /ActualText (very node and its counterpart are at the same location in ) /K [ 342 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5030 0 obj << /ActualText (these four networks) /K [ 343 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5031 0 obj << /ActualText ( ) /K [ 344 ] /P 4896 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5032 0 obj << /Alt () /K [ 237 ] /P 4896 0 R /Pg 112 0 R /S /InlineShape /Type /StructElem >> endobj 5033 0 obj << /Alt () /K [ 240 ] /P 4896 0 R /Pg 112 0 R /S /InlineShape /Type /StructElem >> endobj 5034 0 obj << /Alt () /K [ 245 ] /P 4896 0 R /Pg 112 0 R /S /InlineShape /Type /StructElem >> endobj 5035 0 obj << /Alt () /K [ 249 ] /P 4896 0 R /Pg 112 0 R /S /InlineShape /Type /StructElem >> endobj 5036 0 obj << /Obj 239 0 R /Pg 112 0 R /Type /OBJR >> endobj 5037 0 obj << /ActualText (30) /K [ 258 ] /P 4945 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5038 0 obj << /K [ 5039 0 R 5040 0 R 5041 0 R 5042 0 R 5043 0 R 5044 0 R 5045 0 R 5046 0 R 5047 0 R 5048 0 R 5049 0 R 5050 0 R 5051 0 R 5052 0 R 5053 0 R 5054 0 R 5055 0 R 5056 0 R 5057 0 R 5058 0 R 5059 0 R 5060 0 R 5061 0 R 5062 0 R 5063 0 R 5064 0 R 5065 0 R 5066 0 R 5067 0 R 5068 0 R 5069 0 R 5070 0 R 5071 0 R 5072 0 R 5073 0 R 5074 0 R 5075 0 R 5076 0 R 5077 0 R 5078 0 R 5079 0 R 5080 0 R 5081 0 R 5082 0 R 5083 0 R 5084 0 R 5085 0 R ] /P 257 0 R /Pg 112 0 R /S /P /Type /StructElem >> endobj 5039 0 obj << /ActualText (In addition) /K [ 345 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5040 0 obj << /ActualText ( ) /K [ 346 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5041 0 obj << /ActualText (to) /K [ 347 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5042 0 obj << /ActualText ( ) /K [ 348 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5043 0 obj << /ActualText (the 70 common genes, TKDS considers the relationships between these genes and the ) /K [ 349 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5044 0 obj << /ActualText (genes that are ) /K [ 350 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5045 0 obj << /ActualText (exclusively present) /K [ 351 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5046 0 obj << /ActualText ( ) /K [ 352 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5047 0 obj << /ActualText (in the cancer network and constructs the kernel differential subgraph ) /K [ 353 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5048 0 obj << /ActualText (\(KDS\) in cancer state with 21 additional genes added. Interestingly, by searching the COSMIC ) /K [ 354 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5049 0 obj << /ActualText (database) /K [ 355 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5050 0 obj << /ActualText ([) /K [ 356 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5051 0 obj << /K [ 5086 0 R 5087 0 R ] /P 5038 0 R /Pg 112 0 R /S /Link /Type /StructElem >> endobj 5052 0 obj << /ActualText (]) /K [ 358 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5053 0 obj << /ActualText (, we found 3 of the 21 genes that cause non) /K [ 359 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5054 0 obj << /ActualText (-) /K [ 360 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5055 0 obj << /ActualText (small cell lung cancer \(NSC) /K [ 361 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5056 0 obj << /ActualText (LC\). ) /K [ 362 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5057 0 obj << /ActualText (In addition,) /K [ 363 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5058 0 obj << /ActualText ( ) /K [ 364 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5059 0 obj << /ActualText (two subnet) /K [ 365 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5060 0 obj << /ActualText (s) /K [ 366 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5061 0 obj << /ActualText ( ) /K [ 367 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5062 0 obj << /ActualText (are obtained ) /K [ 368 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5063 0 obj << /ActualText (from) /K [ 369 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5064 0 obj << /ActualText ( ) /K [ 370 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5065 0 obj << /ActualText (the 3 genes and their ) /K [ 371 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5066 0 obj << /ActualText (neighbours) /K [ 372 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5067 0 obj << /ActualText (. ) /K [ 373 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5068 0 obj << /ActualText (As noted in) /K [ 374 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5069 0 obj << /ActualText ( ) /K [ 375 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5070 0 obj << /ActualText (Fig. ) /K [ 376 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5071 0 obj << /ActualText (7) /K [ 377 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5072 0 obj << /ActualText (, there are ) /K [ 378 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5073 0 obj << /ActualText (two ) /K [ 379 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5074 0 obj << /ActualText (subnet) /K [ 380 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5075 0 obj << /ActualText (s) /K [ 381 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5076 0 obj << /ActualText ( ) /K [ 382 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5077 0 obj << /ActualText (in ) /K [ 383 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5078 0 obj << /ActualText (the ) /K [ 384 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5079 0 obj << /ActualText (cancer state) /K [ 385 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5080 0 obj << /ActualText ( ) /K [ 386 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5081 0 obj << /ActualText (containing the new) /K [ 387 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5082 0 obj << /ActualText (ly) /K [ 388 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5083 0 obj << /ActualText ( ) /K [ 389 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5084 0 obj << /ActualText (added genes PIK3CB, MAP2K2 and AKT1.) /K [ 390 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5085 0 obj << /ActualText ( ) /K [ 391 ] /P 5038 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5086 0 obj << /Obj 240 0 R /Pg 112 0 R /Type /OBJR >> endobj 5087 0 obj << /ActualText (31) /K [ 357 ] /P 5051 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5088 0 obj << /K [ 5089 0 R ] /P 257 0 R /Pg 112 0 R /S /P /Type /StructElem >> endobj 5089 0 obj << /ActualText ( ) /K [ 392 ] /P 5088 0 R /Pg 112 0 R /S /Span /Type /StructElem >> endobj 5090 0 obj << /K [ 393 ] /P 257 0 R /Pg 112 0 R /S /Figure /Type /StructElem >> endobj 5091 0 obj << /K [ 5092 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5092 0 obj << /ActualText ( ) /K [ 0 ] /P 5091 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5093 0 obj << /K [ 199 ] /P 257 0 R /Pg 120 0 R /S /Figure /Type /StructElem >> endobj 5094 0 obj << /K [ 5095 0 R 5096 0 R 5097 0 R 5098 0 R 5099 0 R 5100 0 R 5101 0 R 5102 0 R 5103 0 R 5104 0 R 5105 0 R 5106 0 R 5107 0 R 5108 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5095 0 obj << /ActualText (Fig. ) /K [ 1 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5096 0 obj << /ActualText (6) /K [ 2 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5097 0 obj << /ActualText (.) /K [ 3 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5098 0 obj << /ActualText ( ) /K [ 4 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5099 0 obj << /ActualText (Overall network and isolated KDS in the cancer and normal states. The blue nodes represent 30 genes that are common to ) /K [ 5 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5100 0 obj << /ActualText (both the cancer and normal states, the red nodes represent the differential genes that connect to the 30 genes represented in) /K [ 6 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5101 0 obj << /ActualText ( ) /K [ 7 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5102 0 obj << /ActualText (blue) /K [ 8 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5103 0 obj << /ActualText (;) /K [ 9 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5104 0 obj << /ActualText ( ) /K [ 10 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5105 0 obj << /ActualText (the ) /K [ 11 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5106 0 obj << /ActualText (green nodes represent the common nodes added using the proposed method, and the small black nodes are the ordinary genes ) /K [ 12 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5107 0 obj << /ActualText (that do not exist in the KDS.) /K [ 13 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5108 0 obj << /ActualText ( ) /K [ 14 ] /P 5094 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5109 0 obj << /K [ 5110 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5110 0 obj << /ActualText ( ) /K [ 15 ] /P 5109 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5111 0 obj << /K [ 5112 0 R 5113 0 R 5114 0 R 5115 0 R 5116 0 R 5117 0 R 5118 0 R 5119 0 R 5120 0 R 5121 0 R 5122 0 R 5123 0 R 5124 0 R 5125 0 R 5126 0 R 5127 0 R 5128 0 R 5129 0 R 5130 0 R 5131 0 R 5132 0 R 5133 0 R 5134 0 R 5135 0 R 5136 0 R 5137 0 R 5138 0 R 5139 0 R 5140 0 R 5141 0 R 5142 0 R 5143 0 R 5144 0 R 5145 0 R 5146 0 R 5147 0 R 5148 0 R 5149 0 R 5150 0 R 5151 0 R 5152 0 R 5153 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5112 0 obj << /ActualText (The above two functional modules mainly relate to important molecules of ) /K [ 16 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5113 0 obj << /ActualText (the ) /K [ 17 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5114 0 obj << /ActualText (PI3K/) /K [ 18 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5115 0 obj << /ActualText (AKT) /K [ 19 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5116 0 obj << /ActualText (, MAPK ) /K [ 20 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5117 0 obj << /ActualText (and PRKC ) /K [ 21 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5118 0 obj << /ActualText (signalling pathways.) /K [ 22 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5119 0 obj << /ActualText ( ) /K [ 23 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5120 0 obj << /ActualText (The PI3K/AKT signal transduction pathway plays an important role in ) /K [ 24 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5121 0 obj << /ActualText (the regulation of cell survival and proliferation) /K [ 25 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5122 0 obj << /ActualText (. PI3K/AKT signalling) /K [ 26 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5123 0 obj << /ActualText ( ) /K [ 27 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5124 0 obj << /ActualText (dysfunction play) /K [ 28 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5125 0 obj << /ActualText (s) /K [ 29 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5126 0 obj << /ActualText ( ) /K [ 30 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5127 0 obj << /ActualText (a) /K [ 31 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5128 0 obj << /ActualText ( ) /K [ 32 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5129 0 obj << /ActualText (crucial role in ) /K [ 33 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5130 0 obj << /ActualText (multiple ) /K [ 34 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5131 0 obj << /ActualText (tumo) /K [ 35 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5132 0 obj << /ActualText (u) /K [ 36 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5133 0 obj << /ActualText (rigenesis) /K [ 37 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5134 0 obj << /ActualText ( ) /K [ 38 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5135 0 obj << /ActualText (and development) /K [ 39 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5136 0 obj << /ActualText ( ) /K [ 40 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5137 0 obj << /ActualText (models) /K [ 41 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5138 0 obj << /ActualText ( ) /K [ 42 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5139 0 obj << /ActualText (and ) /K [ 43 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5140 0 obj << /ActualText (is ) /K [ 44 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5141 0 obj << /ActualText (associ) /K [ 45 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5142 0 obj << /ActualText (ate) /K [ 46 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5143 0 obj << /ActualText (d) /K [ 47 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5144 0 obj << /ActualText ( ) /K [ 48 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5145 0 obj << /ActualText (with tumour anti) /K [ 49 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5146 0 obj << /ActualText (-) /K [ 50 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5147 0 obj << /ActualText (apoptosis, ) /K [ 51 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5148 0 obj << /ActualText (migration and invasion) /K [ 52 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5149 0 obj << /ActualText ([) /K [ 53 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5150 0 obj << /K [ 5154 0 R 5155 0 R ] /P 5111 0 R /Pg 120 0 R /S /Link /Type /StructElem >> endobj 5151 0 obj << /ActualText (]) /K [ 55 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5152 0 obj << /ActualText (. ) /K [ 56 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5153 0 obj << /ActualText ( ) /K [ 57 ] /P 5111 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5154 0 obj << /Obj 241 0 R /Pg 120 0 R /Type /OBJR >> endobj 5155 0 obj << /ActualText (32) /K [ 54 ] /P 5150 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5156 0 obj << /K [ 5157 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5157 0 obj << /ActualText ( ) /K [ 58 ] /P 5156 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5158 0 obj << /K [ 5159 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5159 0 obj << /ActualText ( ) /K [ 59 ] /P 5158 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5160 0 obj << /K [ 200 ] /P 257 0 R /Pg 120 0 R /S /Figure /Type /StructElem >> endobj 5161 0 obj << /K [ 5162 0 R 5163 0 R 5164 0 R 5165 0 R 5166 0 R 5167 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5162 0 obj << /ActualText (Fig. ) /K [ 60 ] /P 5161 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5163 0 obj << /ActualText (7) /K [ 61 ] /P 5161 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5164 0 obj << /ActualText (. Functional) /K [ 62 ] /P 5161 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5165 0 obj << /ActualText ( ) /K [ 63 ] /P 5161 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5166 0 obj << /ActualText (modules in the KDS containing newly added genes related to NSCLC) /K [ 64 ] /P 5161 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5167 0 obj << /ActualText ( ) /K [ 65 ] /P 5161 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5168 0 obj << /K [ 5169 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5169 0 obj << /ActualText ( ) /K [ 66 ] /P 5168 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5170 0 obj << /ActualText (Studies have ) /K [ 67 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5171 0 obj << /K [ 5170 0 R 5172 0 R 5173 0 R 5174 0 R 5175 0 R 5176 0 R 5177 0 R 5178 0 R 5179 0 R 5182 0 R 5183 0 R 5184 0 R 5185 0 R 5186 0 R 5187 0 R 5188 0 R 5189 0 R 5190 0 R 5191 0 R 5192 0 R 5193 0 R 5194 0 R 5195 0 R 5196 0 R 5197 0 R 5198 0 R 5199 0 R 5200 0 R 5201 0 R 5202 0 R 5203 0 R 5204 0 R 5205 0 R 5206 0 R 5207 0 R 5208 0 R 5209 0 R 5210 0 R 5211 0 R 5212 0 R 5213 0 R 5214 0 R 5215 0 R 5216 0 R 5217 0 R 5218 0 R 5219 0 R 5220 0 R 5221 0 R 5222 0 R 5223 0 R 5224 0 R 5225 0 R 5226 0 R 5227 0 R 5228 0 R 5229 0 R 5230 0 R 5231 0 R 5232 0 R 5233 0 R 5234 0 R 5235 0 R 5236 0 R 5237 0 R 5238 0 R 5239 0 R 5240 0 R 5241 0 R 5242 0 R 5243 0 R 5244 0 R 5245 0 R 5246 0 R 5247 0 R 5248 0 R 5249 0 R 5252 0 R 5253 0 R 5254 0 R 5255 0 R 5256 0 R 5257 0 R 5258 0 R 5259 0 R 5260 0 R 5261 0 R ] /P 257 0 R /Pg 120 0 R /S /P /Type /StructElem >> endobj 5172 0 obj << /ActualText (demonstrated) /K [ 68 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5173 0 obj << /ActualText ( ) /K [ 69 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5174 0 obj << /ActualText (abnormal up) /K [ 70 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5175 0 obj << /ActualText (-) /K [ 71 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5176 0 obj << /ActualText (regulation of PI3K in breast cancer, prostate cancer, ) /K [ 72 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5177 0 obj << /ActualText (ovarian cancer, colorectal cancer and other human malignancies) /K [ 73 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5178 0 obj << /ActualText ([) /K [ 74 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5179 0 obj << /K [ 5180 0 R 5181 0 R ] /P 5171 0 R /Pg 120 0 R /S /Link /Type /StructElem >> endobj 5180 0 obj << /Obj 242 0 R /Pg 120 0 R /Type /OBJR >> endobj 5181 0 obj << /ActualText (33) /K [ 75 ] /P 5179 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5182 0 obj << /ActualText (]) /K [ 76 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5183 0 obj << /ActualText (. Class 1A phosphatidylinositol ) /K [ 77 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5184 0 obj << /ActualText (kinases \(PI3Ks\) are important core molecules in the PI3K/AKT signal transduction pathway that are ) /K [ 78 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5185 0 obj << /ActualText (mainly activated by various kinases and G protein) /K [ 79 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5186 0 obj << /ActualText (-) /K [ 80 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5187 0 obj << /ActualText (coupled receptors. PI3K is a lipid) /K [ 81 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5188 0 obj << /ActualText ( ) /K [ 82 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5189 0 obj << /ActualText (kinase family ) /K [ 83 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5190 0 obj << /ActualText (consisting of a catalytic subunit ) /K [ 84 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5191 0 obj << /ActualText (\() /K [ 85 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5192 0 obj << /ActualText (PIK3C) /K [ 86 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5193 0 obj << /ActualText (\)) /K [ 87 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5194 0 obj << /ActualText ( ) /K [ 88 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5195 0 obj << /ActualText (and a regulatory subunit \(PIK3R\), in which the catalytic subunit ) /K [ 89 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5196 0 obj << /ActualText (contains four members) /K [ 90 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5197 0 obj << /ActualText (.) /K [ 91 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5198 0 obj << /ActualText ( ) /K [ 92 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5199 0 obj << /ActualText (PIK3CB protein is widely abundant in the cell) /K [ 93 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5200 0 obj << /ActualText (,) /K [ 94 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5201 0 obj << /ActualText ( ) /K [ 95 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5202 0 obj << /ActualText (regulates) /K [ 96 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5203 0 obj << /ActualText ( ) /K [ 97 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5204 0 obj << /ActualText (synthesis and promot) /K [ 98 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5205 0 obj << /ActualText (es) /K [ 99 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5206 0 obj << /ActualText ( ) /K [ 100 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5207 0 obj << /ActualText (the normal development of cells) /K [ 101 ] /P 5171 0 R /Pg 120 0 R /S /Span /Type /StructElem >> endobj 5208 0 obj << /ActualText (. 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/StructElem >> endobj 5357 0 obj << /ActualText (KDS) /K [ 43 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5358 0 obj << /ActualText ( ) /K [ 44 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5359 0 obj << /ActualText (is more differential ) /K [ 45 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5360 0 obj << /ActualText (than the ) /K [ 46 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5361 0 obj << /ActualText (original network, we compute ) /K [ 47 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5362 0 obj << /ActualText (the PE and EC score) /K [ 48 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5363 0 obj << /ActualText (s) /K [ 49 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5364 0 obj << /ActualText ( ) /K [ 50 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5365 0 obj << /ActualText (for ) /K [ 51 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5366 0 obj << /ActualText (the ) /K [ 52 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5367 0 obj << /ActualText (original network) /K [ 53 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5368 0 obj << /ActualText ( ) /K [ 54 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5369 0 obj << /ActualText (and) /K [ 56 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5370 0 obj << /ActualText ( ) /K [ 57 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5371 0 obj << /ActualText ( ) /K [ 59 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5372 0 obj << /ActualText (and ) /K [ 60 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5373 0 obj << /ActualText (the ) /K [ 61 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5374 0 obj << /ActualText (KDS) /K [ 62 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5375 0 obj << /ActualText ( ) /K [ 63 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5376 0 obj << /ActualText ( ) /K [ 65 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5377 0 obj << /ActualText (and) /K [ 66 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5378 0 obj << /ActualText ( ) /K [ 67 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5379 0 obj << /ActualText (.) /K [ 69 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5380 0 obj << /ActualText ( ) /K [ 70 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5381 0 obj << /ActualText (Table ) /K [ 71 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5382 0 obj << /ActualText (3) /K [ 72 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5383 0 obj << /ActualText ( ) /K [ 73 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5384 0 obj << /ActualText (list) /K [ 74 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5385 0 obj << /ActualText (s) /K [ 75 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5386 0 obj << /ActualText ( ) /K [ 76 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5387 0 obj << /ActualText (the values ) /K [ 77 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5388 0 obj << /ActualText (obtained ) /K [ 78 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5389 0 obj << /ActualText (using ) /K [ 79 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5390 0 obj << /ActualText (the ) /K [ 80 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5391 0 obj << /ActualText (different methods.) /K [ 81 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5392 0 obj << /ActualText ( ) /K [ 82 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5393 0 obj << /ActualText (PE and EC show, to ) /K [ 83 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5394 0 obj << /ActualText (a certain) /K [ 84 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5395 0 obj << /ActualText ( ) /K [ 85 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5396 0 obj << /ActualText (extent, the similarity of ) /K [ 86 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5397 0 obj << /ActualText (the two networks. ) /K [ 87 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5398 0 obj << /ActualText (T) /K [ 88 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5399 0 obj << /ActualText (he ) /K [ 89 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5400 0 obj << /ActualText (TKDS ) /K [ 90 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5401 0 obj << /ActualText (PE) /K [ 91 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5402 0 obj << /ActualText ( ) /K [ 92 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5403 0 obj << /ActualText (score of ) /K [ 93 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5404 0 obj << /ActualText (7.86) /K [ 94 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5405 0 obj << /ActualText ( ) /K [ 95 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5406 0 obj << /ActualText (and EC ) /K [ 96 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5407 0 obj << /ActualText (score of) /K [ 97 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5408 0 obj << /ActualText ( ) /K [ 98 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5409 0 obj << /ActualText (0.02 ) /K [ 99 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5410 0 obj << /ActualText (are ) /K [ 100 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5411 0 obj << /ActualText (lower) /K [ 101 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5412 0 obj << /ActualText ( ) /K [ 102 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5413 0 obj << /ActualText (than the ) /K [ 103 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5414 0 obj << /ActualText (original network ) /K [ 104 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5415 0 obj << /ActualText (PE ) /K [ 105 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5416 0 obj << /ActualText (score of ) /K [ 106 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5417 0 obj << /ActualText (60.08 and EC ) /K [ 107 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5418 0 obj << /ActualText (score of) /K [ 108 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5419 0 obj << /ActualText ( ) /K [ 109 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5420 0 obj << /ActualText (0.16) /K [ 110 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5421 0 obj << /ActualText (. ) /K [ 111 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5422 0 obj << /ActualText (Thus) /K [ 112 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5423 0 obj << /ActualText (,) /K [ 113 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5424 0 obj << /ActualText ( ) /K [ 114 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5425 0 obj << /ActualText (the KDS is more differential ) /K [ 115 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5426 0 obj << /ActualText (than ) /K [ 116 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5427 0 obj << /ActualText (the original network.) /K [ 117 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5428 0 obj << /ActualText ( ) /K [ 118 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5429 0 obj << /ActualText (Thus) /K [ 119 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5430 0 obj << /ActualText (, the more differential, the more important ) /K [ 120 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5431 0 obj << /ActualText (it is ) /K [ 121 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5432 0 obj << /ActualText (to reveal the dynamic chang) /K [ 122 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5433 0 obj << /ActualText (e) /K [ 123 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5434 0 obj << /ActualText ( ) /K [ 124 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5435 0 obj << /ActualText (between different states) /K [ 125 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5436 0 obj << /ActualText (.) /K [ 126 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5437 0 obj << /ActualText ( ) /K [ 127 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5438 0 obj << /ActualText (Next, the average PE and EC scores of 100 randomly connected subnets are calculated. The number of ) /K [ 128 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5439 0 obj << /ActualText (genes in the random subnets is equal to that in the ) /K [ 129 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5440 0 obj << /ActualText (differential subnet obtained using the proposed method. ) /K [ 130 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5441 0 obj << /ActualText (The TKDS PE score of 7.86 and the EC score of 0.02 are lower than the scores obtained using the random ) /K [ 131 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5442 0 obj << /ActualText (method. Therefore, the proposed TKDS method is superior to the random method.) /K [ 132 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5443 0 obj << /ActualText ( ) /K [ 133 ] /P 5352 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5444 0 obj << /Alt () /K [ 55 ] /P 5352 0 R /Pg 124 0 R /S /InlineShape /Type /StructElem >> endobj 5445 0 obj << /Alt () /K [ 58 ] /P 5352 0 R /Pg 124 0 R /S /InlineShape /Type /StructElem >> endobj 5446 0 obj << /Alt () /K [ 64 ] /P 5352 0 R /Pg 124 0 R /S /InlineShape /Type /StructElem >> endobj 5447 0 obj << /Alt () /K [ 68 ] /P 5352 0 R /Pg 124 0 R /S /InlineShape /Type /StructElem >> endobj 5448 0 obj << /K [ 5449 0 R 5450 0 R 5451 0 R 5452 0 R 5453 0 R 5454 0 R ] /P 257 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5449 0 obj << /ActualText (Table ) /K [ 134 ] /P 5448 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5450 0 obj << /ActualText (3) /K [ 135 ] /P 5448 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5451 0 obj << /ActualText ( ) /K [ 136 ] /P 5448 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5452 0 obj << /ActualText (PE and EC s) /K [ 137 ] /P 5448 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5453 0 obj << /ActualText (cores obtained using different methods) /K [ 138 ] /P 5448 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5454 0 obj << /ActualText ( ) /K [ 139 ] /P 5448 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5455 0 obj << /K [ 5456 0 R 5457 0 R 5458 0 R 5459 0 R 5460 0 R ] /P 257 0 R /Pg 124 0 R /S /Table /Type /StructElem >> endobj 5456 0 obj << /K [ 5461 0 R 5462 0 R 5463 0 R 5464 0 R 5465 0 R 5466 0 R ] /P 5455 0 R /Pg 124 0 R /S /TR /Type /StructElem >> endobj 5457 0 obj << /K [ 5482 0 R 5483 0 R 5484 0 R 5485 0 R 5486 0 R 5487 0 R ] /P 5455 0 R /Pg 124 0 R /S /TR /Type /StructElem >> endobj 5458 0 obj << /K [ 5513 0 R 5514 0 R 5515 0 R 5516 0 R 5517 0 R ] /P 5455 0 R /Pg 124 0 R /S /TR /Type /StructElem >> endobj 5459 0 obj << /K [ 5533 0 R 5534 0 R 5535 0 R 5536 0 R 5537 0 R ] /P 5455 0 R /Pg 124 0 R /S /TR /Type /StructElem >> endobj 5460 0 obj << /K [ 5563 0 R 5564 0 R 5565 0 R 5566 0 R 5567 0 R 5568 0 R ] /P 5455 0 R /Pg 124 0 R /S /TR /Type /StructElem >> endobj 5461 0 obj << /K [ 5467 0 R ] /P 5456 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5462 0 obj << /K [ 5470 0 R ] /P 5456 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5463 0 obj << /K [ 5473 0 R ] /P 5456 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5464 0 obj << /K [ 5476 0 R ] /P 5456 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5465 0 obj << /K [ 5479 0 R ] /P 5456 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5466 0 obj << /K 234 /P 5456 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5467 0 obj << /K [ 5468 0 R 5469 0 R ] /P 5461 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5468 0 obj << /ActualText (Item) /K [ 224 ] /P 5467 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5469 0 obj << /ActualText ( ) /K [ 225 ] /P 5467 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5470 0 obj << /K [ 5471 0 R 5472 0 R ] /P 5462 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5471 0 obj << /ActualText (Nodes in cancer ) /K [ 226 ] /P 5470 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5472 0 obj << /ActualText ( ) /K [ 227 ] /P 5470 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5473 0 obj << /K [ 5474 0 R 5475 0 R ] /P 5463 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5474 0 obj << /ActualText (Nodes in normal state) /K [ 228 ] /P 5473 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5475 0 obj << /ActualText ( ) /K [ 229 ] /P 5473 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5476 0 obj << /K [ 5477 0 R 5478 0 R ] /P 5464 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5477 0 obj << /ActualText (PE score) /K [ 230 ] /P 5476 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5478 0 obj << /ActualText ( ) /K [ 231 ] /P 5476 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5479 0 obj << /K [ 5480 0 R 5481 0 R ] /P 5465 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5480 0 obj << /ActualText (EC score) /K [ 232 ] /P 5479 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5481 0 obj << /ActualText ( ) /K [ 233 ] /P 5479 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5482 0 obj << /K [ 5488 0 R 5489 0 R ] /P 5457 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5483 0 obj << /K [ 5493 0 R 5494 0 R ] /P 5457 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5484 0 obj << /K [ 5498 0 R 5499 0 R ] /P 5457 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5485 0 obj << /K [ 5503 0 R 5504 0 R ] /P 5457 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5486 0 obj << /K [ 5508 0 R 5509 0 R ] /P 5457 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5487 0 obj << /K 255 /P 5457 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5488 0 obj << /K 235 /P 5482 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5489 0 obj << /K [ 5490 0 R 5491 0 R 5492 0 R ] /P 5482 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5490 0 obj << /K 236 /P 5489 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5491 0 obj << /ActualText (Original) /K [ 237 ] /P 5489 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5492 0 obj << /ActualText ( ) /K [ 238 ] /P 5489 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5493 0 obj << /K 239 /P 5483 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5494 0 obj << /K [ 5495 0 R 5496 0 R 5497 0 R ] /P 5483 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5495 0 obj << /K 240 /P 5494 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5496 0 obj << /ActualText (186) /K [ 241 ] /P 5494 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5497 0 obj << /ActualText ( ) /K [ 242 ] /P 5494 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5498 0 obj << /K 243 /P 5484 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5499 0 obj << /K [ 5500 0 R 5501 0 R 5502 0 R ] /P 5484 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5500 0 obj << /K 244 /P 5499 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5501 0 obj << /ActualText (192) /K [ 245 ] /P 5499 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5502 0 obj << /ActualText ( ) /K [ 246 ] /P 5499 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5503 0 obj << /K 247 /P 5485 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5504 0 obj << /K [ 5505 0 R 5506 0 R 5507 0 R ] /P 5485 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5505 0 obj << /K 248 /P 5504 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5506 0 obj << /ActualText (60.08) /K [ 249 ] /P 5504 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5507 0 obj << /ActualText ( ) /K [ 250 ] /P 5504 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5508 0 obj << /K 251 /P 5486 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5509 0 obj << /K [ 5510 0 R 5511 0 R 5512 0 R ] /P 5486 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5510 0 obj << /K 252 /P 5509 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5511 0 obj << /ActualText (0.16) /K [ 253 ] /P 5509 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5512 0 obj << /ActualText ( ) /K [ 254 ] /P 5509 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5513 0 obj << /K [ 5518 0 R ] /P 5458 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5514 0 obj << /K [ 5521 0 R ] /P 5458 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5515 0 obj << /K [ 5524 0 R ] /P 5458 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5516 0 obj << /K [ 5527 0 R ] /P 5458 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5517 0 obj << /K [ 5530 0 R ] /P 5458 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5518 0 obj << /K [ 5519 0 R 5520 0 R ] /P 5513 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5519 0 obj << /ActualText (TKDS) /K [ 256 ] /P 5518 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5520 0 obj << /ActualText ( ) /K [ 257 ] /P 5518 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5521 0 obj << /K [ 5522 0 R 5523 0 R ] /P 5514 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5522 0 obj << /ActualText (51) /K [ 258 ] /P 5521 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5523 0 obj << /ActualText ( ) /K [ 259 ] /P 5521 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5524 0 obj << /K [ 5525 0 R 5526 0 R ] /P 5515 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5525 0 obj << /ActualText (44) /K [ 260 ] /P 5524 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5526 0 obj << /ActualText ( ) /K [ 261 ] /P 5524 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5527 0 obj << /K [ 5528 0 R 5529 0 R ] /P 5516 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5528 0 obj << /ActualText (7.86) /K [ 262 ] /P 5527 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5529 0 obj << /ActualText ( ) /K [ 263 ] /P 5527 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5530 0 obj << /K [ 5531 0 R 5532 0 R ] /P 5517 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5531 0 obj << /ActualText (0.02) /K [ 264 ] /P 5530 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5532 0 obj << /ActualText ( ) /K [ 265 ] /P 5530 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5533 0 obj << /K [ 5538 0 R 5539 0 R ] /P 5459 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5534 0 obj << /K [ 5543 0 R 5544 0 R ] /P 5459 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5535 0 obj << /K [ 5548 0 R 5549 0 R ] /P 5459 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5536 0 obj << /K [ 5553 0 R 5554 0 R ] /P 5459 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5537 0 obj << /K [ 5558 0 R 5559 0 R ] /P 5459 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5538 0 obj << /K 266 /P 5533 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5539 0 obj << /K [ 5540 0 R 5541 0 R 5542 0 R ] /P 5533 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5540 0 obj << /K 267 /P 5539 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5541 0 obj << /ActualText (Random) /K [ 268 ] /P 5539 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5542 0 obj << /ActualText ( ) /K [ 269 ] /P 5539 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5543 0 obj << /K 270 /P 5534 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5544 0 obj << /K [ 5545 0 R 5546 0 R 5547 0 R ] /P 5534 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5545 0 obj << /K 271 /P 5544 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5546 0 obj << /ActualText (51) /K [ 272 ] /P 5544 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5547 0 obj << /ActualText ( ) /K [ 273 ] /P 5544 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5548 0 obj << /K 274 /P 5535 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5549 0 obj << /K [ 5550 0 R 5551 0 R 5552 0 R ] /P 5535 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5550 0 obj << /K 275 /P 5549 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5551 0 obj << /ActualText (44) /K [ 276 ] /P 5549 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5552 0 obj << /ActualText ( ) /K [ 277 ] /P 5549 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5553 0 obj << /K 278 /P 5536 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5554 0 obj << /K [ 5555 0 R 5556 0 R 5557 0 R ] /P 5536 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5555 0 obj << /K 279 /P 5554 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5556 0 obj << /ActualText (12.65) /K [ 280 ] /P 5554 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5557 0 obj << /ActualText ( ) /K [ 281 ] /P 5554 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5558 0 obj << /K 282 /P 5537 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5559 0 obj << /K [ 5560 0 R 5561 0 R 5562 0 R ] /P 5537 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5560 0 obj << /K 283 /P 5559 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5561 0 obj << /ActualText (0.14) /K [ 284 ] /P 5559 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5562 0 obj << /ActualText ( ) /K [ 285 ] /P 5559 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5563 0 obj << /K [ 5569 0 R ] /P 5460 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5564 0 obj << /K [ 5575 0 R ] /P 5460 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5565 0 obj << /K [ 5578 0 R ] /P 5460 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5566 0 obj << /K [ 5581 0 R ] /P 5460 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5567 0 obj << /K [ 5584 0 R ] /P 5460 0 R /Pg 124 0 R /S /TD /Type /StructElem >> endobj 5568 0 obj << /K 299 /P 5460 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5569 0 obj << /K [ 5570 0 R 5571 0 R 5572 0 R 5573 0 R 5574 0 R ] /P 5563 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5570 0 obj << /ActualText (Shortest path) /K [ 286 ] /P 5569 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5571 0 obj << /ActualText (-) /K [ 287 ] /P 5569 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5572 0 obj << /ActualText (based ) /K [ 288 ] /P 5569 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5573 0 obj << /ActualText (method) /K [ 289 ] /P 5569 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5574 0 obj << /ActualText ( ) /K [ 290 ] /P 5569 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5575 0 obj << /K [ 5576 0 R 5577 0 R ] /P 5564 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5576 0 obj << /ActualText (67) /K [ 291 ] /P 5575 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5577 0 obj << /ActualText ( ) /K [ 292 ] /P 5575 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5578 0 obj << /K [ 5579 0 R 5580 0 R ] /P 5565 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5579 0 obj << /ActualText (54) /K [ 293 ] /P 5578 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5580 0 obj << /ActualText ( ) /K [ 294 ] /P 5578 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5581 0 obj << /K [ 5582 0 R 5583 0 R ] /P 5566 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5582 0 obj << /ActualText (7.51) /K [ 295 ] /P 5581 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5583 0 obj << /ActualText ( ) /K [ 296 ] /P 5581 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5584 0 obj << /K [ 5585 0 R 5586 0 R ] /P 5567 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5585 0 obj << /ActualText (0.10) /K [ 297 ] /P 5584 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5586 0 obj << /ActualText ( ) /K [ 298 ] /P 5584 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5587 0 obj << /K [ 5588 0 R 5589 0 R 5590 0 R 5591 0 R 5592 0 R 5593 0 R 5594 0 R 5595 0 R 5596 0 R 5597 0 R 5598 0 R 5599 0 R 5600 0 R 5601 0 R 5602 0 R 5603 0 R 5604 0 R 5605 0 R 5606 0 R 5607 0 R 5608 0 R 5609 0 R 5610 0 R 5611 0 R 5612 0 R 5613 0 R 5614 0 R 5615 0 R 5616 0 R 5617 0 R 5618 0 R 5619 0 R 5620 0 R 5621 0 R 5622 0 R 5623 0 R 5624 0 R 5625 0 R 5626 0 R 5627 0 R ] /P 257 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5588 0 obj << /ActualText (Certainly, we hope to identify the lowest KDSs possible and ) /K [ 140 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5589 0 obj << /ActualText (enhance ) /K [ 141 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5590 0 obj << /ActualText (the difference as much as ) /K [ 142 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5591 0 obj << /ActualText (possible. Consequently, we propose an intuitive shortest path) /K [ 143 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5592 0 obj << /ActualText (-) /K [ 144 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5593 0 obj << /ActualText (based method to construct the network and ) /K [ 145 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5594 0 obj << /ActualText (union of these paths in a new subgraph.) /K [ 146 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5595 0 obj << /ActualText ( ) /K [ 147 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5596 0 obj << /ActualText (Because of the non) /K [ 148 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5597 0 obj << /ActualText (-) /K [ 149 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5598 0 obj << /ActualText (uniqueness of the shortest path, we repeat ) /K [ 150 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5599 0 obj << /ActualText (this path 50 times. As shown in Table ) /K [ 151 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5600 0 obj << /ActualText (3) /K [ 152 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5601 0 obj << /ActualText (, the TKDS PE score of 7.86 is similar to the shortest path) /K [ 153 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5602 0 obj << /ActualText (-) /K [ 154 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5603 0 obj << /ActualText (based ) /K [ 155 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5604 0 obj << /ActualText (method score of 7.51, and the EC score of 0.02 is lower than the score of 0.10 obtained ) /K [ 156 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5605 0 obj << /ActualText (using the shortest ) /K [ 157 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5606 0 obj << /ActualText (path) /K [ 158 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5607 0 obj << /ActualText (-) /K [ 159 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5608 0 obj << /ActualText (based method. Furthermore, the average ) /K [ 160 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5609 0 obj << /ActualText (number) /K [ 161 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5610 0 obj << /ActualText ( ) /K [ 162 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5611 0 obj << /ActualText (of ) /K [ 163 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5612 0 obj << /ActualText (nodes ) /K [ 164 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5613 0 obj << /ActualText (is ) /K [ 165 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5614 0 obj << /ActualText (67 and 54 using the shortest path) /K [ 166 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5615 0 obj << /ActualText (-) /K [ 167 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5616 0 obj << /ActualText (based ) /K [ 168 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5617 0 obj << /ActualText (method) /K [ 169 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5618 0 obj << /ActualText (,) /K [ 170 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5619 0 obj << /ActualText ( ) /K [ 171 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5620 0 obj << /ActualText (which is ) /K [ 172 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5621 0 obj << /ActualText (greater than ) /K [ 173 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5622 0 obj << /ActualText (the ) /K [ 174 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5623 0 obj << /ActualText (number) /K [ 175 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5624 0 obj << /ActualText ( ) /K [ 176 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5625 0 obj << /ActualText (obtained ) /K [ 177 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5626 0 obj << /ActualText (using the TKDS \(51 and 44\).) /K [ 178 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5627 0 obj << /ActualText ( ) /K [ 179 ] /P 5587 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5628 0 obj << /K [ 5629 0 R ] /P 257 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5629 0 obj << /ActualText ( ) /K [ 180 ] /P 5628 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5630 0 obj << /K [ 223 ] /P 257 0 R /Pg 124 0 R /S /Figure /Type /StructElem >> endobj 5631 0 obj << /K [ 5632 0 R 5633 0 R 5634 0 R 5635 0 R 5636 0 R 5637 0 R 5638 0 R 5639 0 R 5640 0 R 5641 0 R 5642 0 R 5643 0 R 5644 0 R 5645 0 R 5646 0 R 5647 0 R 5648 0 R 5649 0 R 5650 0 R 5651 0 R 5652 0 R 5653 0 R 5654 0 R 5655 0 R 5656 0 R 5657 0 R 5658 0 R 5659 0 R 5660 0 R ] /P 257 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5632 0 obj << /ActualText (Fig. ) /K [ 181 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5633 0 obj << /ActualText (8) /K [ 182 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5634 0 obj << /ActualText (. ) /K [ 183 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5635 0 obj << /ActualText (PE and EC score distributions ) /K [ 184 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5636 0 obj << /ActualText (obtained ) /K [ 185 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5637 0 obj << /ActualText (using ) /K [ 186 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5638 0 obj << /ActualText (different methods. A and B represent the distribution) /K [ 187 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5639 0 obj << /ActualText (s of the ) /K [ 188 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5640 0 obj << /ActualText (PE and EC ) /K [ 189 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5641 0 obj << /ActualText (score) /K [ 190 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5642 0 obj << /ActualText (s) /K [ 191 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5643 0 obj << /ActualText (, respectively) /K [ 192 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5644 0 obj << /ActualText (, obtained with the random method) /K [ 193 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5645 0 obj << /ActualText (. C and D display the tendenc) /K [ 194 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5646 0 obj << /ActualText (ies) /K [ 195 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5647 0 obj << /ActualText ( ) /K [ 196 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5648 0 obj << /ActualText (of ) /K [ 197 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5649 0 obj << /ActualText (the ) /K [ 198 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5650 0 obj << /ActualText (PE and EC score) /K [ 199 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5651 0 obj << /ActualText (s) /K [ 200 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5652 0 obj << /ActualText (, respectively) /K [ 201 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5653 0 obj << /ActualText (, ) /K [ 202 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5654 0 obj << /ActualText (obtained with the shortest) /K [ 203 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5655 0 obj << /ActualText (-) /K [ 204 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5656 0 obj << /ActualText (path) /K [ 205 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5657 0 obj << /ActualText (-) /K [ 206 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5658 0 obj << /ActualText (based method) /K [ 207 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5659 0 obj << /ActualText (.) /K [ 208 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5660 0 obj << /ActualText ( ) /K [ 209 ] /P 5631 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5661 0 obj << /K [ 5662 0 R ] /P 257 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5662 0 obj << /ActualText ( ) /K [ 210 ] /P 5661 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5663 0 obj << /K [ 5664 0 R 5665 0 R 5666 0 R 5667 0 R 5668 0 R 5669 0 R 5670 0 R 5671 0 R 5672 0 R 5673 0 R 5674 0 R 5675 0 R ] /P 257 0 R /Pg 124 0 R /S /P /Type /StructElem >> endobj 5664 0 obj << /ActualText (Fig. ) /K [ 211 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5665 0 obj << /ActualText (8) /K [ 212 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5666 0 obj << /ActualText ( ) /K [ 213 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5667 0 obj << /ActualText (A and) /K [ 214 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5668 0 obj << /ActualText ( ) /K [ 215 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5669 0 obj << /ActualText (B present the distribution of the PE and EC values in the random subnet, and the ) /K [ 216 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5670 0 obj << /ActualText (p) /K [ 217 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5671 0 obj << /ActualText (-) /K [ 218 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5672 0 obj << /ActualText (values calculated using single sample ) /K [ 219 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5673 0 obj << /ActualText (t) /K [ 220 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5674 0 obj << /ActualText (-) /K [ 221 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5675 0 obj << /ActualText (tests in SPSS are less than 0.01. The distribution of the PE and ) /K [ 222 ] /P 5663 0 R /Pg 124 0 R /S /Span /Type /StructElem >> endobj 5676 0 obj << /K [ 5677 0 R 5678 0 R 5679 0 R 5680 0 R 5681 0 R 5682 0 R 5683 0 R 5684 0 R 5685 0 R ] /P 257 0 R /Pg 132 0 R /S /P /Type /StructElem >> endobj 5677 0 obj << /ActualText (EC values using the proposed and the shortest path) /K [ 0 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5678 0 obj << /ActualText (-) /K [ 1 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5679 0 obj << /ActualText (based methods ar) /K [ 2 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5680 0 obj << /ActualText (e shown in Fig. ) /K [ 3 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5681 0 obj << /ActualText (8) /K [ 4 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5682 0 obj << /ActualText ( ) /K [ 5 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5683 0 obj << /ActualText (C and D, which ) /K [ 6 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5684 0 obj << /ActualText (further illustrate the effectiveness of the proposed method.) /K [ 7 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5685 0 obj << /ActualText ( ) /K [ 8 ] /P 5676 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5686 0 obj << /K [ 5687 0 R ] /P 257 0 R /Pg 132 0 R /S /P /Type /StructElem >> endobj 5687 0 obj << /ActualText ( ) /K [ 9 ] /P 5686 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5688 0 obj << /K [ 5689 0 R 5690 0 R 5691 0 R 5692 0 R 5693 0 R 5694 0 R 5695 0 R 5696 0 R ] /P 257 0 R /Pg 132 0 R /S /H2 /Type /StructElem >> endobj 5689 0 obj << /ActualText (4) /K [ 10 ] /P 5688 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5690 0 obj << /ActualText (.5) /K [ 11 ] /P 5688 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5691 0 obj << /ActualText ( ) /K [ 12 ] /P 5688 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5692 0 obj << /ActualText (GO ) /K [ 13 ] /P 5688 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5693 0 obj << /ActualText (analys) /K [ 14 ] /P 5688 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5694 0 obj << /ActualText (e) /K [ 15 ] /P 5688 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5695 0 obj << /ActualText (s) /K [ 16 ] /P 5688 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5696 0 obj << /ActualText ( ) /K [ 17 ] /P 5688 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5697 0 obj << /ActualText ( ) /K [ 18 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5698 0 obj << /K [ 5697 0 R 5699 0 R 5700 0 R 5701 0 R 5702 0 R 5703 0 R 5704 0 R 5705 0 R 5706 0 R 5707 0 R 5708 0 R 5709 0 R 5710 0 R 5711 0 R 5712 0 R 5713 0 R 5714 0 R 5715 0 R 5716 0 R 5717 0 R 5718 0 R 5719 0 R 5720 0 R 5721 0 R 5722 0 R 5723 0 R 5724 0 R 5725 0 R 5726 0 R 5727 0 R 5728 0 R 5729 0 R 5730 0 R 5731 0 R 5732 0 R 5733 0 R 5734 0 R 5735 0 R 5736 0 R 5737 0 R 5738 0 R 5739 0 R 5740 0 R 5741 0 R 5742 0 R 5743 0 R 5744 0 R 5745 0 R 5746 0 R 5747 0 R 5748 0 R 5749 0 R 5750 0 R 5751 0 R 5752 0 R 5753 0 R 5754 0 R 5755 0 R 5756 0 R 5757 0 R 5758 0 R 5759 0 R 5760 0 R 5761 0 R 5762 0 R 5763 0 R 5764 0 R 5765 0 R 5766 0 R 5767 0 R 5768 0 R 5769 0 R 5770 0 R 5771 0 R 5772 0 R 5773 0 R 5774 0 R 5775 0 R 5776 0 R 5777 0 R 5778 0 R 5779 0 R 5780 0 R 5781 0 R 5782 0 R 5783 0 R 5784 0 R 5785 0 R 5786 0 R 5787 0 R 5788 0 R 5789 0 R 5790 0 R 5791 0 R 5792 0 R 5793 0 R 5794 0 R 5795 0 R 5796 0 R 5797 0 R 5798 0 R 5799 0 R 5800 0 R 5801 0 R 5802 0 R 5803 0 R 5804 0 R 5805 0 R 5806 0 R 5807 0 R 5808 0 R 5809 0 R 5810 0 R 5811 0 R 5812 0 R 5813 0 R 5814 0 R 5815 0 R 5816 0 R 5817 0 R 5818 0 R 5819 0 R 5820 0 R 5821 0 R 5822 0 R 5823 0 R 5824 0 R 5825 0 R 5826 0 R 5827 0 R 5828 0 R 5829 0 R 5830 0 R 5831 0 R 5832 0 R 5833 0 R 5834 0 R 5835 0 R ] /P 257 0 R /Pg 132 0 R /S /P /Type /StructElem >> endobj 5699 0 obj << /ActualText (GO analys) /K [ 19 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5700 0 obj << /ActualText (e) /K [ 20 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5701 0 obj << /ActualText (s ha) /K [ 21 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5702 0 obj << /ActualText (ve) /K [ 22 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5703 0 obj << /ActualText ( ) /K [ 23 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5704 0 obj << /ActualText (been widely used ) /K [ 24 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5705 0 obj << /ActualText (to ) /K [ 25 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5706 0 obj << /ActualText (functional) /K [ 26 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5707 0 obj << /ActualText (ly) /K [ 27 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5708 0 obj << /ActualText ( ) /K [ 28 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5709 0 obj << /ActualText (defin) /K [ 29 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5710 0 obj << /ActualText (e) /K [ 30 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5711 0 obj << /ActualText ( ) /K [ 31 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5712 0 obj << /ActualText (and ) /K [ 32 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5713 0 obj << /ActualText (describ) /K [ 33 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5714 0 obj << /ActualText (e ) /K [ 34 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5715 0 obj << /ActualText (genes and proteins.) /K [ 35 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5716 0 obj << /ActualText ( ) /K [ 36 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5717 0 obj << /ActualText (In this ) /K [ 37 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5718 0 obj << /ActualText (study) /K [ 38 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5719 0 obj << /ActualText (, we ) /K [ 39 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5720 0 obj << /ActualText (map) /K [ 40 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5721 0 obj << /ActualText (ped) /K [ 41 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5722 0 obj << /ActualText ( ) /K [ 42 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5723 0 obj << /ActualText (these) /K [ 43 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5724 0 obj << /ActualText ( ) /K [ 44 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5725 0 obj << /ActualText (differential) /K [ 45 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5726 0 obj << /ActualText (ly) /K [ 46 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5727 0 obj << /ActualText ( ) /K [ 47 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5728 0 obj << /ActualText (changing) /K [ 48 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5729 0 obj << /ActualText ( ) /K [ 49 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5730 0 obj << /ActualText (genes ) /K [ 50 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5731 0 obj << /ActualText (with ) /K [ 51 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5732 0 obj << /ActualText (D) /K [ 52 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5733 0 obj << /ActualText (-) /K [ 53 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5734 0 obj << /ActualText (value) /K [ 54 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5735 0 obj << /ActualText (s) /K [ 55 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5736 0 obj << /ActualText ( ) /K [ 56 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5737 0 obj << /ActualText (greater than 0.4 ) /K [ 57 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5738 0 obj << /ActualText (to ) /K [ 58 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5739 0 obj << /ActualText (the ) /K [ 59 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5740 0 obj << /ActualText (GO items) /K [ 60 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5741 0 obj << /ActualText ( ) /K [ 61 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5742 0 obj << /ActualText (of ) /K [ 62 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5743 0 obj << /ActualText (biological process \() /K [ 63 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5744 0 obj << /ActualText (BP) /K [ 64 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5745 0 obj << /ActualText (\)) /K [ 65 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5746 0 obj << /ActualText (, ) /K [ 66 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5747 0 obj << /ActualText (molecular ) /K [ 67 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5748 0 obj << /ActualText (function \() /K [ 68 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5749 0 obj << /ActualText (MF) /K [ 69 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5750 0 obj << /ActualText (\)) /K [ 70 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5751 0 obj << /ActualText ( ) /K [ 71 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5752 0 obj << /ActualText (and ) /K [ 72 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5753 0 obj << /ActualText (cellular component \() /K [ 73 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5754 0 obj << /ActualText (CC) /K [ 74 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5755 0 obj << /ActualText (\)) /K [ 75 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5756 0 obj << /ActualText ( ) /K [ 76 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5757 0 obj << /ActualText (using ) /K [ 77 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5758 0 obj << /ActualText (the ) /K [ 78 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5759 0 obj << /ActualText (Gene Ontology ) /K [ 79 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5760 0 obj << /ActualText (Consortium) /K [ 80 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5761 0 obj << /ActualText ( ) /K [ 81 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5762 0 obj << /ActualText (database) /K [ 82 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5763 0 obj << /ActualText ([) /K [ 83 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5764 0 obj << /K [ 5836 0 R 5837 0 R ] /P 5698 0 R /Pg 132 0 R /S /Link /Type /StructElem >> endobj 5765 0 obj << /ActualText (, ) /K [ 85 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5766 0 obj << /K [ 5838 0 R 5839 0 R ] /P 5698 0 R /Pg 132 0 R /S /Link /Type /StructElem >> endobj 5767 0 obj << /ActualText (]) /K [ 87 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5768 0 obj << /ActualText (.) /K [ 88 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5769 0 obj << /ActualText ( ) /K [ 89 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5770 0 obj << /ActualText (Fig. ) /K [ 90 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5771 0 obj << /ActualText (9) /K [ 91 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5772 0 obj << /ActualText ( ) /K [ 92 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5773 0 obj << /ActualText (presents ) /K [ 93 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5774 0 obj << /ActualText (the) /K [ 94 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5775 0 obj << /ActualText ( ) /K [ 95 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5776 0 obj << /ActualText (categories of) /K [ 96 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5777 0 obj << /ActualText ( ) /K [ 97 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5778 0 obj << /ActualText (the ) /K [ 98 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5779 0 obj << /ActualText (GO ) /K [ 99 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5780 0 obj << /ActualText (functions) /K [ 100 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5781 0 obj << /ActualText ( ) /K [ 101 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5782 0 obj << /ActualText (of the ) /K [ 102 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5783 0 obj << /ActualText (genes with the ) /K [ 103 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5784 0 obj << /ActualText (top ) /K [ 104 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5785 0 obj << /ActualText (30 D) /K [ 105 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5786 0 obj << /ActualText (-) /K [ 106 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5787 0 obj << /ActualText (value) /K [ 107 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5788 0 obj << /ActualText (s) /K [ 108 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5789 0 obj << /ActualText (. ) /K [ 109 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5790 0 obj << /ActualText (As shown) /K [ 110 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5791 0 obj << /ActualText ( ) /K [ 111 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5792 0 obj << /ActualText (below) /K [ 112 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5793 0 obj << /ActualText (, ) /K [ 113 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5794 0 obj << /ActualText (the ) /K [ 114 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5795 0 obj << /ActualText (four leading ) /K [ 115 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5796 0 obj << /ActualText (process) /K [ 116 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5797 0 obj << /ActualText (es) /K [ 117 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5798 0 obj << /ActualText ( ) /K [ 118 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5799 0 obj << /ActualText (of response to stimulations, biological ) /K [ 119 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5800 0 obj << /ActualText (regulation, metabolic process and cell communication) /K [ 120 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5801 0 obj << /ActualText ( ) /K [ 121 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5802 0 obj << /ActualText (are ) /K [ 122 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5803 0 obj << /ActualText (the most ) /K [ 123 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5804 0 obj << /ActualText (enriched ) /K [ 124 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5805 0 obj << /ActualText (with the formation and ) /K [ 125 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5806 0 obj << /ActualText (development of ) /K [ 126 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5807 0 obj << /ActualText (a ) /K [ 127 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5808 0 obj << /ActualText (tumour) /K [ 128 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5809 0 obj << /ActualText (.) /K [ 129 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5810 0 obj << /ActualText ( ) /K [ 130 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5811 0 obj << /ActualText (M) /K [ 131 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5812 0 obj << /ActualText (embrane ) /K [ 132 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5813 0 obj << /ActualText (and nucle) /K [ 133 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5814 0 obj << /ActualText (ar genes) /K [ 134 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5815 0 obj << /ActualText ( ) /K [ 135 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5816 0 obj << /ActualText (account for) /K [ 136 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5817 0 obj << /ActualText ( ) /K [ 137 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5818 0 obj << /ActualText (a large proportion) /K [ 138 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5819 0 obj << /ActualText ( ) /K [ 139 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5820 0 obj << /ActualText (of the ) /K [ 140 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5821 0 obj << /ActualText (cellular ) /K [ 141 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5822 0 obj << /ActualText (component) /K [ 142 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5823 0 obj << /ActualText (,) /K [ 143 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5824 0 obj << /ActualText ( ) /K [ 144 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5825 0 obj << /ActualText (a) /K [ 145 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5826 0 obj << /ActualText (nd protein binding plays a key role in function) /K [ 146 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5827 0 obj << /ActualText (al molecular) /K [ 147 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5828 0 obj << /ActualText ( ) /K [ 148 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5829 0 obj << /ActualText (process) /K [ 149 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5830 0 obj << /ActualText (es) /K [ 150 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5831 0 obj << /ActualText ([) /K [ 151 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5832 0 obj << /K [ 5840 0 R 5841 0 R ] /P 5698 0 R /Pg 132 0 R /S /Link /Type /StructElem >> endobj 5833 0 obj << /ActualText (]) /K [ 153 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5834 0 obj << /ActualText (.) /K [ 154 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5835 0 obj << /ActualText ( ) /K [ 155 ] /P 5698 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5836 0 obj << /Obj 246 0 R /Pg 132 0 R /Type /OBJR >> endobj 5837 0 obj << /ActualText (37) /K [ 84 ] /P 5764 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5838 0 obj << /Obj 247 0 R /Pg 132 0 R /Type /OBJR >> endobj 5839 0 obj << /ActualText (38) /K [ 86 ] /P 5766 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5840 0 obj << /Obj 248 0 R /Pg 132 0 R /Type /OBJR >> endobj 5841 0 obj << /ActualText (39) /K [ 152 ] /P 5832 0 R /Pg 132 0 R /S /Span /Type /StructElem >> endobj 5842 0 obj << /K [ 5843 0 R ] /P 257 0 R /Pg 132 0 R 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6327 0 R 6328 0 R 6329 0 R 6330 0 R 6331 0 R 6332 0 R 6333 0 R 6334 0 R 6335 0 R 6336 0 R 6337 0 R 6338 0 R 6339 0 R 6340 0 R 6341 0 R 6342 0 R 6343 0 R 6344 0 R 6345 0 R 6346 0 R 6347 0 R 6348 0 R 6349 0 R ] /P 257 0 R /Pg 136 0 R /S /P /Type /StructElem >> endobj 6326 0 obj << /ActualText ( ) /K [ 326 ] /P 6325 0 R /Pg 136 0 R /S /Span /Type /StructElem >> endobj 6327 0 obj << /ActualText (The differences between networks of different conditions, such as stages of disease development, ) /K [ 327 ] /P 6325 0 R /Pg 136 0 R /S /Span /Type /StructElem >> endobj 6328 0 obj << /ActualText (occur ) /K [ 328 ] /P 6325 0 R /Pg 136 0 R /S /Span /Type /StructElem >> endobj 6329 0 obj << /ActualText (as a result of) /K [ 329 ] /P 6325 0 R /Pg 136 0 R /S /Span /Type /StructElem >> endobj 6330 0 obj << /ActualText ( ) /K [ 330 ] /P 6325 0 R /Pg 136 0 R /S /Span /Type /StructElem >> endobj 6331 0 obj << /ActualText (changes ) /K [ 331 ] /P 6325 0 R /Pg 136 0 R /S /Span /Type /StructElem >> endobj 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6349 0 obj << /ActualText (TKDS ) /K [ 349 ] /P 6325 0 R /Pg 136 0 R /S /Span /Type /StructElem >> endobj 6350 0 obj << /K [ 6351 0 R 6352 0 R 6353 0 R 6354 0 R 6355 0 R 6356 0 R 6357 0 R 6358 0 R 6359 0 R 6360 0 R 6361 0 R 6362 0 R 6363 0 R 6364 0 R 6365 0 R 6366 0 R 6367 0 R 6368 0 R 6369 0 R 6370 0 R 6371 0 R 6372 0 R 6373 0 R 6374 0 R 6375 0 R 6376 0 R 6377 0 R 6378 0 R 6379 0 R ] /P 257 0 R /Pg 139 0 R /S /P /Type /StructElem >> endobj 6351 0 obj << /ActualText (method considers topological difference) /K [ 0 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6352 0 obj << /ActualText (s) /K [ 1 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6353 0 obj << /ActualText ( ) /K [ 2 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6354 0 obj << /ActualText (not only between the common nodes, which are described by ) /K [ 3 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6355 0 obj << /ActualText (D) /K [ 4 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6356 0 obj << /ActualText (-) /K [ 5 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6357 0 obj << /ActualText (values) /K [ 6 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6358 0 obj << /ActualText (,) /K [ 7 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6359 0 obj << /ActualText ( ) /K [ 8 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6360 0 obj << /ActualText (but also) /K [ 9 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6361 0 obj << /ActualText ( ) /K [ 10 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6362 0 obj << /ActualText (different nodes that are omitted by other methods. In addition, TKDS ) /K [ 11 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6363 0 obj << /ActualText (considers) /K [ 12 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6364 0 obj << /ActualText ( ) /K [ 13 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6365 0 obj << /ActualText (the ) /K [ 14 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6366 0 obj << /ActualText (relationships between common and diff) /K [ 15 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6367 0 obj << /ActualText (erent nodes. ) /K [ 16 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6368 0 obj << /ActualText (As previously described, ) /K [ 17 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6369 0 obj << /ActualText (kDDN is an excellent ) /K [ 18 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6370 0 obj << /ActualText (algorithm for comparing differences in networks with ) /K [ 19 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6371 0 obj << /ActualText (the ) /K [ 20 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6372 0 obj << /ActualText (same nodes) /K [ 21 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6373 0 obj << /ActualText (. We therefore compared our ) /K [ 22 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6374 0 obj << /ActualText (topology) /K [ 23 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6375 0 obj << /ActualText (-) /K [ 24 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6376 0 obj << /ActualText (based method TKDS with ) /K [ 25 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6377 0 obj << /ActualText (kDDN) /K [ 26 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6378 0 obj << /ActualText (. ) /K [ 27 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6379 0 obj << /ActualText ( ) /K [ 28 ] /P 6350 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6380 0 obj << /K [ 6381 0 R 6382 0 R 6383 0 R 6384 0 R 6385 0 R 6386 0 R 6387 0 R 6388 0 R 6389 0 R 6390 0 R 6391 0 R 6392 0 R 6393 0 R 6394 0 R 6395 0 R 6396 0 R 6397 0 R 6398 0 R 6399 0 R 6400 0 R 6401 0 R 6402 0 R 6403 0 R 6404 0 R 6405 0 R 6406 0 R 6407 0 R 6408 0 R 6409 0 R 6410 0 R 6411 0 R 6412 0 R 6413 0 R 6414 0 R 6415 0 R 6416 0 R 6417 0 R 6418 0 R 6419 0 R 6420 0 R 6421 0 R 6422 0 R 6423 0 R 6424 0 R 6425 0 R 6426 0 R 6427 0 R 6428 0 R 6429 0 R 6430 0 R 6431 0 R 6432 0 R 6433 0 R 6434 0 R 6435 0 R 6436 0 R 6437 0 R 6438 0 R 6439 0 R 6440 0 R 6441 0 R 6442 0 R 6443 0 R 6444 0 R 6445 0 R 6446 0 R 6447 0 R 6448 0 R 6449 0 R 6450 0 R 6451 0 R 6452 0 R 6453 0 R 6454 0 R ] /P 257 0 R /Pg 139 0 R /S /P /Type /StructElem >> endobj 6381 0 obj << /ActualText (In the 70 common genes, a) /K [ 29 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6382 0 obj << /ActualText (fter) /K [ 30 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6383 0 obj << /ActualText ( ) /K [ 31 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6384 0 obj << /ActualText (computing the centrality of the n) /K [ 32 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6385 0 obj << /ActualText (etwork response to cancerization, ) /K [ 33 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6386 0 obj << /ActualText (13 overlapp) /K [ 34 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6387 0 obj << /ActualText (ing) /K [ 35 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6388 0 obj << /ActualText ( ) /K [ 36 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6389 0 obj << /ActualText (genes in the ) /K [ 37 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6390 0 obj << /ActualText (top ) /K [ 38 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6391 0 obj << /ActualText (30 differential) /K [ 39 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6392 0 obj << /ActualText ( ) /K [ 40 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6393 0 obj << /ActualText (genes ) /K [ 41 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6394 0 obj << /ActualText (were identified) /K [ 42 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6395 0 obj << /ActualText ( ) /K [ 43 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6396 0 obj << /ActualText (by TKDS \(top30) /K [ 44 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6397 0 obj << /ActualText (-) /K [ 45 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6398 0 obj << /ActualText (TKDS\) and kDDN ) /K [ 46 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6399 0 obj << /ActualText (\(top30) /K [ 47 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6400 0 obj << /ActualText (-) /K [ 48 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6401 0 obj << /ActualText (kDDN\).) /K [ 49 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6402 0 obj << /ActualText ( ) /K [ 50 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6403 0 obj << /ActualText (Both methods identified the following) /K [ 51 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6404 0 obj << /ActualText ( ) /K [ 52 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6405 0 obj << /ActualText (13) /K [ 53 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6406 0 obj << /ActualText ( ) /K [ 54 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6407 0 obj << /ActualText (genes:) /K [ 55 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6408 0 obj << /ActualText ( ) /K [ 56 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6409 0 obj << /ActualText (SOS1, CDK4) /K [ 57 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6410 0 obj << /ActualText (, ) /K [ 58 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6411 0 obj << /ActualText (ALK, STK4, ARAF, ) /K [ 59 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6412 0 obj << /ActualText (NRAS, HRAS, CLDND1, EGFR, AKT3,) /K [ 60 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type 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70 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6423 0 obj << /ActualText (-) /K [ 71 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6424 0 obj << /ActualText (TKDS are ) /K [ 72 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6425 0 obj << /ActualText (all) /K [ 73 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6426 0 obj << /ActualText ( ) /K [ 74 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6427 0 obj << /ActualText (related to cancer) /K [ 75 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6428 0 obj << /ActualText ( ) /K [ 76 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6429 0 obj << /ActualText (as demonstrated by) /K [ 77 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6430 0 obj << /ActualText ( ) /K [ 78 ] /P 6380 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6431 0 obj << /ActualText (literature mining) /K [ 79 ] /P 6380 0 R /Pg 139 0 R /S 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Interestingly, ) /K [ 176 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6532 0 obj << /ActualText (by searching the COSMIC database, we ) /K [ 177 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6533 0 obj << /ActualText (identified) /K [ 178 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6534 0 obj << /ActualText ( ) /K [ 179 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6535 0 obj << /ActualText (3 of the 21 genes tha) /K [ 180 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6536 0 obj << /ActualText (t cause non) /K [ 181 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6537 0 obj << /ActualText (-) /K [ 182 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6538 0 obj << /ActualText (small cell lung cancer ) /K [ 183 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6539 0 obj << /ActualText (\(NSCLC\). ) /K [ 184 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type 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0 obj << /ActualText (The two functional modules ) /K [ 194 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6550 0 obj << /ActualText (shown in Fig. 7 are ) /K [ 195 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6551 0 obj << /ActualText (mainly relate) /K [ 196 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6552 0 obj << /ActualText (d) /K [ 197 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6553 0 obj << /ActualText ( ) /K [ 198 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6554 0 obj << /ActualText (to important molecules of the PI3K/AKT, MAPK and PRKC signalling ) /K [ 199 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6555 0 obj << /ActualText (pathways) /K [ 200 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6556 0 obj << /ActualText ( ) /K [ 201 ] /P 6490 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6557 0 obj << /ActualText (which play ) /K [ 202 ] /P 6490 0 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0 obj << /ActualText ( ) /K [ 213 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6576 0 obj << /ActualText (In this study, we proposed) /K [ 214 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6577 0 obj << /ActualText ( ) /K [ 215 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6578 0 obj << /ActualText (the TKDS method, ) /K [ 216 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6579 0 obj << /ActualText (a ) /K [ 217 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6580 0 obj << /ActualText (topology) /K [ 218 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6581 0 obj << /ActualText (-) /K [ 219 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6582 0 obj << /ActualText (based method) /K [ 220 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6583 0 obj << /ActualText (, ) /K [ 221 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6584 0 obj << /ActualText (to ) /K [ 222 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6585 0 obj << /ActualText (infer) /K [ 223 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6586 0 obj << /ActualText ( ) /K [ 224 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6587 0 obj << /ActualText (the ) /K [ 225 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6588 0 obj << /ActualText (KDS ) /K [ 226 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6589 0 obj << /ActualText (from gene ) /K [ 227 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6590 0 obj << /ActualText (regulatory networks with different nodes.) /K [ 228 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6591 0 obj << /ActualText ( ) /K [ 229 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6592 0 obj << /ActualText (For the common nodes, the TKDS method considers the ) /K [ 230 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6593 0 obj << /ActualText (D) /K [ 231 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6594 0 obj << /ActualText (-) /K [ 232 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6595 0 obj << /ActualText (value) /K [ 233 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6596 0 obj << /ActualText ( ) /K [ 234 ] /P 6574 0 R /Pg 139 0 R /S /Span /Type /StructElem >> endobj 6597 0 obj << /ActualText (of the topological change. 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Lyon, France: International Agency for Research on Cancer ) /K [ 23 ] /P 6743 0 R /Pg 142 0 R /S /Span /Type /StructElem >> endobj 6750 0 obj << /ActualText (2013.[Visitado 2014 Dic 22]) /K [ 24 ] /P 6743 0 R /Pg 142 0 R /S /Span /Type /StructElem >> endobj 6751 0 obj << /ActualText (. 2016.) /K [ 25 ] /P 6743 0 R /Pg 142 0 R /S /Span /Type /StructElem >> endobj 6752 0 obj << /ActualText ( ) /K [ 26 ] /P 6743 0 R /Pg 142 0 R /S /Span /Type /StructElem >> endobj 6753 0 obj << /ActualText (2.) /K [ 27 ] /P 6754 0 R /Pg 142 0 R /S /Span /Type /StructElem >> endobj 6754 0 obj << /K [ 6753 0 R 6755 0 R 6756 0 R 6757 0 R 6758 0 R 6759 0 R 6760 0 R 6761 0 R 6762 0 R 6763 0 R 6764 0 R 6765 0 R 6766 0 R ] /P 257 0 R /Pg 142 0 R /S /P /Type /StructElem >> endobj 6755 0 obj << /ActualText ( ) /K [ 28 ] /P 6754 0 R /Pg 142 0 R /S /Span /Type /StructElem >> endobj 6756 0 obj << /ActualText (Emmert) /K [ 29 ] /P 6754 0 R /Pg 142 0 R /S /Span /Type /StructElem >> endobj 6757 0 obj << /ActualText (-) 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His main research topics) /K [ 111 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7433 0 obj << /ActualText ( ) /K [ 112 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7434 0 obj << /ActualText (are ) /K [ 113 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7435 0 obj << /ActualText (bioinformatics and ) /K [ 114 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7436 0 obj << /ActualText (high) /K [ 115 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7437 0 obj << /ActualText (-) /K [ 116 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7438 0 obj << /ActualText (performance) /K [ 117 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7439 0 obj << /ActualText ( ) /K [ 118 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7440 0 obj << /ActualText (computing.) /K [ 119 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7441 0 obj << /ActualText ( ) /K [ 120 ] /P 7275 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7442 0 obj << /ActualText ( ) /K [ 121 ] /P 7276 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7443 0 obj << /ActualText (Jiao Wang) /K [ 122 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7444 0 obj << /ActualText ( ) /K [ 123 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7445 0 obj << /ActualText (received her Ph.D) /K [ 124 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7446 0 obj << /ActualText (.) /K [ 125 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7447 0 obj << /ActualText ( ) /K [ 126 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7448 0 obj << /ActualText (in neural science from Shanghai University, China ) /K [ 127 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7449 0 obj << /ActualText (in 2012. She is currently an assistant professor ) /K [ 128 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7450 0 obj << /ActualText (at the) /K [ 129 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7451 0 obj << /ActualText ( ) /K [ 130 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7452 0 obj << /ActualText (Life Science Centre. Her main ) /K [ 131 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7453 0 obj << /ActualText (research topics) /K [ 132 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7454 0 obj << /ActualText ( ) /K [ 133 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7455 0 obj << /ActualText (include brain research, bioinformatics and neural degeneration disease.) /K [ 134 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7456 0 obj << /ActualText ( ) /K [ 135 ] /P 7277 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7457 0 obj << /ActualText ( ) /K [ 136 ] /P 7279 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7458 0 obj << /ActualText ( ) /K [ 137 ] /P 7280 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7459 0 obj << /ActualText (Yong Zhang) /K [ 138 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7460 0 obj << /ActualText ( ) /K [ 139 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7461 0 obj << /ActualText (received his MD. & PH.D in pulmonary department from Fudan ) /K [ 140 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7462 0 obj << /ActualText (University, Shanghai, China in 2013. He is currently associated ) /K [ 141 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7463 0 obj << /ActualText (consultant doctor of ) /K [ 142 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7464 0 obj << /ActualText (pulmonary department in Zhongshan hospital. He is also member and reviewer of ) /K [ 143 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7465 0 obj << /ActualText (Springer, member of Chinese Medical Association. He is experienced in lung cancer ) /K [ 144 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7466 0 obj << /ActualText (screening, also devote to lung cancer biomarker detection and molecular mec) /K [ 145 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7467 0 obj << /ActualText (hanism ) /K [ 146 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7468 0 obj << /ActualText (with genomic sequencing and bioinformatics methods.) /K [ 147 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7469 0 obj << /ActualText ( ) /K [ 148 ] /P 7281 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7470 0 obj << /ActualText (Yanhui Li) /K [ 149 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7471 0 obj << /ActualText ( ) /K [ 150 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7472 0 obj << /ActualText (received her BS degree in ) /K [ 151 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7473 0 obj << /ActualText (pharmaceutical engineering) /K [ 152 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7474 0 obj << /ActualText ( ) /K [ 153 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7475 0 obj << /ActualText (from ) /K [ 154 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7476 0 obj << /ActualText (Anhui ) /K [ 155 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7477 0 obj << /ActualText (University of Science and Technology) /K [ 156 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7478 0 obj << /ActualText (, China in 201) /K [ 157 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7479 0 obj << /ActualText (5) /K [ 158 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7480 0 obj << /ActualText (. She is currently a postgraduate ) /K [ 159 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7481 0 obj << /ActualText (at the ) /K [ 160 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7482 0 obj << /ActualText (Life Science ) /K [ 161 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7483 0 obj << /ActualText (Centre) /K [ 162 ] /P 7283 0 R /Pg 162 0 R /S /Span /Type /StructElem >> endobj 7484 0 obj << /ActualText (. 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1883 0 R 1884 0 R 1885 0 R 1886 0 R 1926 0 R 1887 0 R 1888 0 R 1889 0 R 1890 0 R 1891 0 R 1892 0 R 1893 0 R 1894 0 R 1895 0 R 1896 0 R 1897 0 R 1898 0 R 1899 0 R 1900 0 R 1901 0 R 1902 0 R 1903 0 R 1904 0 R 1905 0 R 1906 0 R 1907 0 R 1908 0 R 1909 0 R 1910 0 R 1911 0 R 1912 0 R 1913 0 R 1928 0 R 1929 0 R 1930 0 R 1931 0 R 1932 0 R 1933 0 R 1934 0 R 1935 0 R 1936 0 R 1937 0 R 1938 0 R 1939 0 R 1940 0 R 1974 0 R 1941 0 R 1942 0 R 1943 0 R 1975 0 R 1944 0 R 1945 0 R 1946 0 R 1947 0 R 1948 0 R 1949 0 R 1950 0 R 1951 0 R 1952 0 R 1953 0 R 1954 0 R 1955 0 R 1956 0 R 1957 0 R 1958 0 R 1959 0 R 1960 0 R 1976 0 R 1961 0 R 1962 0 R 1963 0 R 1964 0 R 1965 0 R 1966 0 R 1967 0 R 1968 0 R 1969 0 R 1970 0 R 1971 0 R 1972 0 R 1973 0 R 1719 0 R ] endobj 7507 0 obj [ 1978 0 R 1985 0 R 1979 0 R 1980 0 R 1981 0 R 1982 0 R 1983 0 R 1984 0 R 1987 0 R 1988 0 R 1989 0 R 2050 0 R 1990 0 R 1991 0 R 1992 0 R 2051 0 R 1993 0 R 1994 0 R 1995 0 R 1996 0 R 1997 0 R 1998 0 R 1999 0 R 2000 0 R 2052 0 R 2001 0 R 2002 0 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2240 0 R 2241 0 R 2242 0 R 2243 0 R 2244 0 R 2245 0 R 2246 0 R 2247 0 R 2248 0 R 2249 0 R 2250 0 R 2251 0 R 2252 0 R 2253 0 R 2254 0 R 2255 0 R 2256 0 R 2276 0 R 2257 0 R 2258 0 R 2259 0 R 2277 0 R 2260 0 R 2261 0 R 2262 0 R 2263 0 R 2264 0 R 2265 0 R 2266 0 R 2267 0 R 2278 0 R 2268 0 R 2269 0 R 2270 0 R 2271 0 R 2272 0 R 2273 0 R 2274 0 R 2275 0 R 2281 0 R 2282 0 R 2283 0 R 2284 0 R 2285 0 R 2286 0 R 2288 0 R 2289 0 R 2290 0 R 2291 0 R 2292 0 R 2293 0 R 2294 0 R 2295 0 R 2296 0 R 2338 0 R 2297 0 R 2298 0 R 2299 0 R 2300 0 R 2301 0 R 2339 0 R 2302 0 R 2303 0 R 2304 0 R 2340 0 R 2305 0 R 2306 0 R 2307 0 R 2308 0 R 2309 0 R 2310 0 R 2311 0 R 2312 0 R 2313 0 R 2314 0 R 2341 0 R 2315 0 R 2316 0 R 2317 0 R 2318 0 R 2342 0 R 2319 0 R 2320 0 R 2321 0 R 2322 0 R 2323 0 R 2343 0 R 2324 0 R 2325 0 R 2326 0 R 2327 0 R 2328 0 R 2329 0 R 2330 0 R 2331 0 R 2332 0 R 2344 0 R 2333 0 R 2334 0 R 2335 0 R 2336 0 R 2337 0 R 2346 0 R 2352 0 R 2347 0 R 2348 0 R 2349 0 R 2350 0 R 2351 0 R 2354 0 R 2360 0 R 2355 0 R 2356 0 R 2357 0 R 2358 0 R 2359 0 R 2362 0 R 2363 0 R 2364 0 R 2365 0 R 2366 0 R 2367 0 R 2377 0 R 2368 0 R 2369 0 R 2370 0 R 2378 0 R 2371 0 R 2379 0 R 2372 0 R 2373 0 R 2374 0 R 2380 0 R 2375 0 R 2376 0 R 2382 0 R 2383 0 R 2384 0 R 2385 0 R 2386 0 R 2387 0 R 2388 0 R 2389 0 R 2390 0 R 2391 0 R 2393 0 R 2394 0 R 2395 0 R 2396 0 R 2397 0 R 2398 0 R 2399 0 R 2400 0 R 2401 0 R 2402 0 R 2403 0 R 2404 0 R 2431 0 R 2405 0 R 2406 0 R 2407 0 R 2432 0 R 2408 0 R 2409 0 R 2410 0 R 2411 0 R 2412 0 R 2413 0 R 2433 0 R 2414 0 R 2415 0 R 2416 0 R 2417 0 R 2418 0 R 2419 0 R 2420 0 R 2421 0 R 2422 0 R 2423 0 R 2424 0 R 2425 0 R 2426 0 R 2427 0 R 2428 0 R 2434 0 R 2429 0 R 2430 0 R 2092 0 R 2279 0 R ] endobj 7508 0 obj [ 2436 0 R 2437 0 R 2438 0 R 2439 0 R 2440 0 R 2441 0 R 2442 0 R 2443 0 R 2444 0 R 2445 0 R 2446 0 R 2447 0 R 2448 0 R 2449 0 R 2450 0 R 2451 0 R 2452 0 R 2453 0 R 2454 0 R 2455 0 R 2456 0 R 2457 0 R 2458 0 R 2459 0 R 2460 0 R 2461 0 R 2462 0 R 2463 0 R 2464 0 R 2535 0 R 2465 0 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2581 0 R 2582 0 R 2583 0 R 2584 0 R 2585 0 R 2586 0 R 2587 0 R 2588 0 R 2589 0 R 2590 0 R 2591 0 R 2592 0 R 2593 0 R 2594 0 R 2595 0 R 2596 0 R 2597 0 R 2598 0 R 2599 0 R 2626 0 R 2600 0 R 2601 0 R 2602 0 R 2603 0 R 2604 0 R 2605 0 R 2606 0 R 2607 0 R 2608 0 R 2609 0 R 2610 0 R 2611 0 R 2612 0 R 2613 0 R 2614 0 R 2615 0 R 2616 0 R 2617 0 R 2618 0 R 2619 0 R 2620 0 R 2621 0 R 2622 0 R 2623 0 R 2624 0 R 2628 0 R 2633 0 R 2635 0 R 2636 0 R 2637 0 R 2632 0 R 2641 0 R 2643 0 R 2644 0 R 2645 0 R 2646 0 R 2647 0 R 2648 0 R 2649 0 R 2650 0 R 2651 0 R 2640 0 R 2654 0 R 2656 0 R 2657 0 R 2658 0 R 2659 0 R 2662 0 R 2666 0 R 2667 0 R 2668 0 R 2669 0 R 2670 0 R 2671 0 R 2672 0 R 2673 0 R 2674 0 R 2675 0 R 2676 0 R 2677 0 R 2678 0 R 2679 0 R 2680 0 R 2681 0 R 2682 0 R 2683 0 R 2684 0 R 2685 0 R 2686 0 R 2687 0 R 2688 0 R 2689 0 R 2690 0 R 2691 0 R 2694 0 R 2696 0 R 2697 0 R 2698 0 R 2699 0 R 2700 0 R 2701 0 R 2702 0 R 2703 0 R 2704 0 R 2705 0 R 2706 0 R 2707 0 R 2710 0 R 2712 0 R 2713 0 R 2714 0 R 2715 0 R 2716 0 R 2717 0 R 2718 0 R 2719 0 R 2720 0 R 2723 0 R 2725 0 R 2726 0 R 2727 0 R 2728 0 R 2729 0 R 2730 0 R 2731 0 R 2732 0 R 2733 0 R 2734 0 R 2735 0 R 2736 0 R 2737 0 R 2740 0 R 2741 0 R 2742 0 R 2743 0 R 2744 0 R 2745 0 R 2746 0 R 2747 0 R 2748 0 R 2749 0 R 2750 0 R 2751 0 R 2752 0 R 2754 0 R 2755 0 R 2756 0 R 2757 0 R 2758 0 R 2759 0 R 2764 0 R 2765 0 R 2766 0 R 2767 0 R 2768 0 R 2769 0 R 2770 0 R 2771 0 R 2772 0 R 2773 0 R 2774 0 R 2775 0 R 2776 0 R 2777 0 R 2778 0 R 2779 0 R 2780 0 R 2781 0 R 2782 0 R 2783 0 R 2786 0 R 2790 0 R 2791 0 R 2792 0 R 2793 0 R 2794 0 R 2795 0 R 2796 0 R 2797 0 R 2798 0 R 2799 0 R 2800 0 R 2801 0 R 2802 0 R 2803 0 R 2804 0 R 2805 0 R 2806 0 R 2807 0 R 2808 0 R 2809 0 R 2810 0 R 2811 0 R 2812 0 R 2813 0 R 2814 0 R 2815 0 R 2816 0 R 2817 0 R 2818 0 R 2819 0 R 2820 0 R 2821 0 R 2822 0 R 2785 0 R 2824 0 R 2826 0 R 2827 0 R 2828 0 R 2829 0 R 2830 0 R 2831 0 R 2833 0 R 2836 0 R 2837 0 R 2838 0 R 2839 0 R 2840 0 R 2841 0 R 2842 0 R 2844 0 R 2845 0 R 2846 0 R 2847 0 R 2848 0 R 2849 0 R 2861 0 R 2862 0 R 2864 0 R 2865 0 R 2867 0 R 2868 0 R 2870 0 R 2871 0 R 2873 0 R 2874 0 R 2876 0 R 2877 0 R 2884 0 R 2886 0 R 2887 0 R 2888 0 R 2889 0 R 2891 0 R 2892 0 R 2893 0 R 2894 0 R 2895 0 R 2896 0 R 2898 0 R 2899 0 R 2900 0 R 2901 0 R 2902 0 R 2904 0 R 2905 0 R 2906 0 R 2907 0 R 2908 0 R 2910 0 R 2911 0 R 2912 0 R 2913 0 R 2914 0 R 2916 0 R 2917 0 R 2918 0 R 2919 0 R 2927 0 R 2928 0 R 2929 0 R 2930 0 R 2932 0 R 2933 0 R 2935 0 R 2936 0 R 2938 0 R 2939 0 R 2941 0 R 2942 0 R 2944 0 R 2945 0 R 2947 0 R 2949 0 R 2950 0 R 2951 0 R 2952 0 R 2953 0 R 2954 0 R 2955 0 R 2956 0 R 2957 0 R 2958 0 R 2959 0 R 2960 0 R 2961 0 R 2962 0 R 2963 0 R 2964 0 R 2965 0 R 2966 0 R 2967 0 R 2968 0 R 2969 0 R 2970 0 R 2971 0 R 2972 0 R 2973 0 R 2974 0 R 2975 0 R 2976 0 R 2977 0 R 2978 0 R 2979 0 R 2980 0 R 2981 0 R 2982 0 R 2983 0 R 2984 0 R 2986 0 R 2989 0 R 2990 0 R 2991 0 R 2993 0 R 2995 0 R 2996 0 R 2997 0 R 2998 0 R 2999 0 R 3000 0 R 3056 0 R 3001 0 R 3002 0 R 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