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Considerations in applying compressed sensing to in vivo phosphorus MR spectroscopic imaging of human brain at 3T

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Abstract

The purpose of this study was to apply compressed sensing method for accelerated phosphorus MR spectroscopic imaging (31P-MRSI) of human brain in vivo at 3T. Fast 31P-MRSI data of five volunteers were acquired on a 3T clinical MR scanner using pulse-acquire sequence with a pseudorandom undersampling pattern for a data reduction factor of 5.33 and were reconstructed using compressed sensing. Additionally, simulated 31P-MRSI human brain tumor datasets were created to analyze the effects of k-space sampling pattern, data matrix size, regularization parameters of the reconstruction, and noise on the compressed sensing accelerated 31P-MRSI data. The 31P metabolite peak ratios of the full and compressed sensing accelerated datasets of healthy volunteers in vivo were similar according to the results of a Bland–Altman test. The estimated effective spatial resolution increased with reduction factor and sampling more at the k-space center. A lower regularization parameter for both total variation and L1-norm penalties resulted in a better compressed sensing reconstruction of 31P-MRSI. Although the root-mean-square error increased with noise levels, the compressed sensing reconstruction was robust for up to a reduction factor of 10 for the simulated data that had sharply defined tumor borders. As a result, compressed sensing was successfully applied to accelerate 31P-MRSI of human brain in vivo at 3T.

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Acknowledgements

This research was supported by TUBITAK Career Development Grant 112E036 and EU Marie Curie IRG Grant FP7-PEOPLE-RG-2009 256528.

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Authors and Affiliations

  1. Biomedical Engineering Institute, Bogazici University, Rasathane Cad, Kandilli Campus, Kandilli Mah., 34684, Istanbul, Turkey

    Gokce Hale Hatay, Muhammed Yildirim & Esin Ozturk-Isik

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  1. Gokce Hale Hatay
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  2. Muhammed Yildirim
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  3. Esin Ozturk-Isik
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Correspondence to Esin Ozturk-Isik.

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Conflict of interest

Gokce Hale Hatay and Esin Ozturk-Isik: no relevant conflicts of interest to disclose. Muhammed Yildirim: financial activities related to the present article: none to disclose. Financial activities not related to the present article: is an employee of Philips Healthcare. Other relationships: none to disclose.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Hatay, G.H., Yildirim, M. & Ozturk-Isik, E. Considerations in applying compressed sensing to in vivo phosphorus MR spectroscopic imaging of human brain at 3T. Med Biol Eng Comput 55, 1303–1315 (2017). https://doi.org/10.1007/s11517-016-1591-9

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  • DOI: https://doi.org/10.1007/s11517-016-1591-9

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