Abstract
Diffusion tensor magnetic resonance imaging (DTMRI) is usually used to detect the displacement distribution of water molecules in biological structure. However, in post-mortem heart fibre imaging, the low spatial resolution does not allow investigating the cardiac fibre structure at microscopic scale. In this paper, the myocyte arrangement of a human heart is investigated at a high resolution of 3.5 μm using the European Synchrotron Radiation Facility (ESRF). The orientation of the myocytes is then computed and extracted at various depths of the heart sample with a multi-scale approach. The helix arrangement of the fibre is obtained at a higher resolution compared to DTMRI. The results show that the measured elevation angles are in good agreement with knowledge of cardiac muscle anatomy. Such high-resolution cardiac fibre orientation information can be used to validate DTMRI measurements and analyze the evolution of cardiac fibre orientations from microscopic level to macroscopic one.
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Varray, F., Wang, L., Fanton, L., Zhu, YM., Magnin, I.E. (2013). High Resolution Extraction of Local Human Cardiac Fibre Orientations. In: Ourselin, S., Rueckert, D., Smith, N. (eds) Functional Imaging and Modeling of the Heart. FIMH 2013. Lecture Notes in Computer Science, vol 7945. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38899-6_18
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DOI: https://doi.org/10.1007/978-3-642-38899-6_18
Publisher Name: Springer, Berlin, Heidelberg
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