Abstract
In this paper, data mining is used to analyze the differentiation of mammalian Mesenchymal Stem Cells (MSCs). A database comprising the key parameters which, we believe, influence the destiny of mammalian MSCs has been constructed. This paper introduces Classification Association Rule Mining (CARM) as a data mining technique in the domain of tissue engineering and initiates a new promising research field. The experimental results show that the proposed approach performs well with respect to the accuracy of (classification) prediction. Moreover, it was found that some rules mined from the constructed MSC database are meaningful and useful.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Agrawal, R., Imielinski, T., Swami, A.: Mining Association Rules between Sets of Items in Large Database. In: Proceedings of the 1993 ACM SIGMOD International Conference on Management of Data, Washington, D.C., USA, pp. 207–216. ACM Press, New York (1993)
Ali, K., Manganaris, S., Srikant, R.: Partial Classification using Association Rules. In: Proceedings of the 3rd International Conference on Knowledge Discovery and Data Mining, Newport Beach, CA, USA, pp. 115–118. AAAI Press, Menlo Park (1997)
Antonie, M.L., Zaiane, O.R.: Text Document Categorization by Term Association. In: Proceedings of the 2002 IEEE International Conference on Data Mining, Maebashi City, Japan, pp. 19–26. IEEE Computer Society Press, Los Alamitos (2002)
Battula, V.L., Bareiss, P.M., Treml, S., Conrad, S., Albert, I., Hojak, S., Abele, H., Schewe, B., Just, L., Skutella, T., Buhring, H.J.: Human Placenta and Bone Marrow derived MSC Cultured in Serum-free, b-FGF-containing Medium Express Cell Surface Frizzled-9 and SSEA-4 and Give Rise to Multilineage Differentiation. Differentiation 75, 279–291 (2007)
Beeres, S.L., Atsma, D.E., van der Laarse, A., Pijnappels, D.A., van Tuyn, J., Fibbe, W.E., de Vries, A.A.F., Ypey, D.L., van der Wall, E.E., Schalij, M.J.: Human Adult Bone Marrow Mesenchymal Stem Cells Repair Experimental Conduction Block in Rat Cardiomyocyte Cultures. American College of Cardiology 46(10), 1943–1952 (2005)
Bianco, P., Riminucci, M., Gronthos, S., Robey, P.G.: Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications. Stem Cells 19, 180–192 (2001)
Boser, B.E., Guyon, I.M., Vapnik, V.N.: A Training Algorithm for Optimal Margin Classifiers. In: Proceedings of the 5th ACM Annual Workshop on Computational Learning Theory, Pittsburgh, PA, USA, pp. 144–152. ACM Press, New York (1992)
Coenen, F., Leng, P.: An Evaluation of Approaches to Classification Rule Selection. In: Proceedings of the 4th IEEE International Conference on Data Mining, Brighton, UK, pp. 359–362. IEEE Computer Society Press, Los Alamitos (2004)
Coenen, F., Leng, P., Zhang, L.: Threshold Tuning for improved Classification Association Rule Mining. In: Ho, T.-B., Cheung, D., Liu, H. (eds.) PAKDD 2005. LNCS, vol. 3518, pp. 216–225. Springer, Heidelberg (2005)
Coenen, F., Leng, P.: The Effect of Threshold Values on Association Rule based Classification Accuracy. Journal of Data and Knowledge Engineering 60(2), 345–360 (2007)
Comelis, C., Yan, P., Zhang, X., Chen, G.: Mining Positive and Negative Association Rules from Large Databases. In: Proceedings of the 2006 IEEE International Conference on Cybernetics and Intelligent Systems, Bangkok, Thailand, pp. 613–618. IEEE Computer Society Press, Los Alamitos (2006)
Derubeis, A.R., Cancedda, R.: Bone Marrow Stromal Cells (BMSCs) in Bone Engineering: Limitations and Recent Advances. Annals of Biomedical Engineering 32(1), 160–165 (2004)
Domingos, P., Pazzani, M.: On the Optimality of the Simple Bayesian Classifier under Zero-one Loss. Machine Learning 29(2/3), 103–130 (1997)
Griffith, L.G., Swartz, M.A.: Capturing Complex 3D Tissue Physiology in Vitro. Nature Reviews Molecular Cell Biology 7, 211–224 (2006)
Hajek, P., Havel, I., Chytil, M.: The GUHA Method of Automatic Hypotheses Determination. Computing 1, 293–308 (1966)
Han, J., Pei, J., Yin, Y.: Mining Frequent Patterns without Candidate Generation. In: Proceedings of the 2000 ACM SIGMOD International Conference on Management of Data, Dallas, TX, USA, pp. 1–12. ACM Press, New York (2000)
Hanada, K., Dennis, J.E., Caplan, A.I.: Stimulatory Effects of Basic Fibroblast Growth Factor and Bone Morphogenetic Protein-2 on Osteogenic Differentiation of Rat Bone Marrow-derived Mesenchymal Stem Cells. Journal of Bone and Mineral Research 12, 1606 (1997)
Haynesworth, S.E., Baber, M.A., Caplan, A.I.: Cytokine Expression by Human Marrow-derived Mesenchymal Progenitor Cells in Vitro: Effects of Dexamethasone and IL-1a. Journal of Cell Physiology 166(3), 585–592 (1996)
James, M.: Classification Algorithm. Wiley Interscience, New York (1985)
Kuznetsov, S.A., Friedenstein, A.J., Robey, P.G.: Factors Required for Bone Marrow Stromal Fibroblast Colony Formation in Vitro. British Journal of Haematology 97, 561–570 (1997)
Lennon, D.P., Haynesworth, S.E., Young, R.G., Dennis, J.E., Caplan, A.I.: A Chemically defined Medium Supports in Vitro Proliferation and Maintains the Osteochondral Potential of Rat Marrow-derived Mesenchymal Stem Cells. Experimental Cell Research 219, 211–222 (1995)
Li, W., Han, J., Pei, J.: CMAR: Accurate and Efficient Classification based on Multiple Class-association Rules. In: Proceedings of the 2001 IEEE International Conference on Data Mining, San Jose, CA, USA, pp. 369–376. IEEE Computer Society Press, Los Alamitos (2001)
Liu, B., Hsu, W., Ma, Y.: Integrating Classification and Association Rule Mining. In: Proceedings of the 4th International Conference on Knowledge Discovery and Data Mining, New York, USA, pp. 80–86. AAAI Press, Menlo Park (1998)
Lowd, D., Domingos, P.: Naive Bayes Models for Probability Estimation. In: Proceedings of the 22nd International Conference on Machine Learning, Bonn, Germany, pp. 529–536. ACM Press, New York (2005)
Magaki, T., Kurisu, K., Okazaki, T.: Generation of Bone Marrow-derived Neural Cells in Serum-free Monolayer Culture. Neuroscience Letters 384, 282–287 (2005)
Meuleman, N., Tondreau, T., Delforge, A., Dejeneffe, M., Massy, M., Libertalis, M., Bron, D., Lagneaux, L.: Human Marrow Mesenchymal Stem Cell Culture: Serum-free Medium Allows Better Expansion than Classical α-MEM Medium. European Journal of Haematology 76(4), 309–316 (2006)
Muller, I., Kordowich, S., Holzwarth, C., Spano, C., Isensee, G., Staiber, A., Viebahn, S., Gieseke, F., Langer, H., Gawaz, M.P., Horwitz, E.M., Conte, P., Handgretinger, R., Dominici, M.: Animal Serum-free Culture Conditions for Isolation and Expansion of Multipotent Mesenchymal Stromal Cells from Human BM. Cytotherapy 8, 437–444 (2006)
Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., Marshak, D.R.: Multilineage Potential of Adult Human Mesenchymal Stem Cells. Science 284(5411), 143–147 (1999)
Quinlan, J.R.: C4.5: Programs for Machine Learning. Morgan Kaufmann Publishers, San Mateo (1993)
Rish, I.: An Empirical Study of the Naive Bayes Classifier. In: Proceedings of the 2001 IJCAI Workshop on Empirical Methods in Artificial Intelligence, Seattle, WA, USA (2001)
Roelen, B.A., Dijke, P.: Controlling Mesenchymal Stem Cell Differentiation by TGFbeta Family Members. Journal of Orthopaedic Science 8, 740–748 (2003)
Srikant, R., Agrawal, R.: Mining Quantitative Association Rules in Large Relational Tables. In: Proceedings of the 1996 ACM SIGMOD International Conference on Management of Data, Montreal, Quebec, Canada, pp. 1–12. ACM Press, New York (1996)
Tuan, R.S., Boland, G., Tuli, R.: Adult Mesenchymal Stem Cell and Cell-based Tissue Engineering. Arthritis Research & Therapy 5, 32–45 (2003)
Wang, Y.J., Xin, Q., Coenen, F.: A Novel Rule Ordering Approach in Classification Association Rule Mining. In: Perner, P. (ed.) MLDM 2007. LNCS, vol. 4571, pp. 339–348. Springer, Heidelberg (2007)
Yoon, Y., Lee, G.G.: Practical Application of Associative Classifier for Document Classification. In: Lee, G.G., Yamada, A., Meng, H., Myaeng, S.-H. (eds.) AIRS 2005. LNCS, vol. 3689, pp. 467–478. Springer, Heidelberg (2005)
Zhang, Y., Li, C., Jiang, X., Zhang, S., Wu, Y., Liu, B., Tang, P., Mao, N.: Human Placenta-derived Mesenchymal Progenitor Cells Support Culture Expansion of Long-term Culture-initiating Cells from Cord Blood CD34+ Cells. Experimental Hematology 32, 657–664 (2004)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Wang, W., Wang, Y.J., Bañares-Alcántara, R., Cui, Z., Coenen, F. (2009). Application of Classification Association Rule Mining for Mammalian Mesenchymal Stem Cell Differentiation. In: Perner, P. (eds) Advances in Data Mining. Applications and Theoretical Aspects. ICDM 2009. Lecture Notes in Computer Science(), vol 5633. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03067-3_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-03067-3_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03066-6
Online ISBN: 978-3-642-03067-3
eBook Packages: Computer ScienceComputer Science (R0)