Abstract
Electronic Health Records (EHRs) have been widely used in healthcare studies recently, such as the analyses for patient diagnostic outcome and understanding of disease progression. EHR is a treasure for researchers who conduct the Real-World study to discovering Real-World Evidence (RWE). In this paper, we design an end-to-end learning system for disease states discovery based on a data-driven strategy. A large-scale proprietary EHR data mart containing about 55 million patients with over 20 billion data records is used for data extraction and analysis. Given a disease of interest, researchers could easily obtain the hidden disease states. Once our system were operational, biomedical researchers could get the results for downstream analyses such as disease prediction, drug design and outcome analyses.
Z. Tang and L. Hu—Contributed equally.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Choi, E., Bahadori, M.T., Schuetz, A., Stewart, W.F., Sun, J.: Doctor AI: predicting clinical events via recurrent neural networks. In: Machine Learning for Healthcare Conference, pp. 301–318 (2016)
Tomasev, N., et al.: A clinically applicable approach to continuous prediction of future acute kidney injury. Nature 572(7767), 116–119 (2019)
Xiao, C., Choi, E., Sun, J.: Opportunities and challenges in developing deep learning models using electronic health records data: a systematic review. J. Am. Med. Inform. Assoc. 25(10), 1419–1428 (2018)
Miotto, R., Wang, F., Wang, S., Jiang, X., Dudley, J.T.: Deep learning for healthcare: review, opportunities and challenges. Briefings Bioinform. 19(6), 1236–1246 (2017)
Tang, Z., Wang, J., Zhang, Y., Hu, P.-W., Li, S., Mei, J.: Uncovering the disease progression profile of patients with type 2 diabetes mellitus and atrial fibrillation. Diabetes 69(Suppl. 1) 1413-P (2020). https://doi.org/10.2337/db20-1413-p
Hu, P.-W., et al.: 450-P: development and validation of a predictive major adverse cardiac events (MACE) risk model for diabetes patients with acute coronary syndrome (ACS). Diabetes 69(Suppl. 1) 450-P (2020). https://doi.org/10.2337/db20-450-p
Huang, Y.-A., Chan, K.C.C., You, Z.-H., Hu, P., Wang, L., Huang, Z.-A.: Predicting microRNA–disease associations from lncRNA–microRNA interactions via multiview multitask learning. Briefings Bioinform. (2020)
Wang, X., Sontag, D., Wang, F.: Unsupervised learning of disease progression models. In: Proceedings of the 20th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, pp. 85–94. ACM (2014)
Jensen, A.B., et al.: Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients. Nat. Commun. 5, 4022 (2014)
Pham, T., Tran, T., Phung, D., Venkatesh, S.: Predicting healthcare trajectories from medical records: a deep learning approach. J. Biomed. Inform. 69, 218–229 (2017)
Liu, B., Li, Y., Sun, Z., Ghosh, S., Ng, K.: Early prediction of diabetes complications from electronic health records: a multi-task survival analysis approach. In: Thirty-Second AAAI Conference on Artificial Intelligence (2018)
Liu, Y.-Y., Li, S., Li, F., Song, L., Rehg, J.M.: Efficient learning of continuous-time hidden markov models for disease progression. In: Advances in Neural Information Processing Systems, pp. 3600–3608 (2015)
Sun, Z., et al.: A probabilistic disease progression modeling approach and its application to integrated Huntington’s disease observational data. JAMIA Open 2(1), 123–130 (2019)
Metzner, P., Schutte, C., Vanden-Eijnden, E.: Transition path theory for markov jump processes. Multiscale Model. Simul. 7(3), 1192–1219 (2009)
Tonneijck, L., et al.: Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment. J. Am. Soc. Nephrol. 28(4), 1023–1039 (2017)
Weldegiorgis, M., et al.: Longitudinal estimated GFR trajectories in patients with and without type 2 diabetes and nephropathy. Am. J. Kidney Diseases 71(1), 91–101 (2018)
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Tang, Z. et al. (2020). Embracing Disease Progression with a Learning System for Real World Evidence Discovery. In: Huang, DS., Jo, KH. (eds) Intelligent Computing Theories and Application. ICIC 2020. Lecture Notes in Computer Science(), vol 12464. Springer, Cham. https://doi.org/10.1007/978-3-030-60802-6_46
Download citation
DOI: https://doi.org/10.1007/978-3-030-60802-6_46
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-60801-9
Online ISBN: 978-3-030-60802-6
eBook Packages: Computer ScienceComputer Science (R0)