Abstract
In brain image analysis many of the current pipelines are not robust to the presence of lesions which degrades their accuracy and robustness. For example, performance of classic medical image processing operations such as non-linear registration or segmentation rapidly decreases when dealing with lesions. To minimize their impact, some authors have proposed to inpaint these lesions so classic pipelines can be used. However, this requires to manually delineate the regions of interest which is time consuming. In this paper, we propose a deep network that is able to blindly inpaint lesions in brain images automatically allowing current pipelines to robustly operate under pathological conditions. We demonstrate the improved robustness/accuracy in the brain segmentation problem using the SPM12 pipeline with our automatically inpainted images.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Bertalmio, M., Sapiro, G., Caselles, V., Ballester, C.: Image inpainting. In: Proceedings of the 27th Annual Conference on Computer Graphics and Interactive Techniques, pp. 417–424 (2000)
Sdika, M., Pelletier, D.: Non rigid registration of multiple sclerosis brain images using lesion inpainting for morphometry or lesion mapping. Hum. Brain Mapp. 30, 1060–1067 (2009)
Guizard, N., Nakamura, K., Coupé, P., Fonov, V., Arnold, D., Collins, L.: Non-local means inpainting of MS lesions in longitudinal image processing. Front. Neurosci. 9, 456 (2015)
Prados, F., Cardoso, M.J., Kanber, B., et al.: A multi-time-point modality-agnostic patch-based method for lesion filling in multiple sclerosis. Neuroimage 139, 376–384 (2016)
Armanious, K., Mecky, Y., Gatidis, S., Yang, B.: Adversarial inpainting of medical image modalisties. In: ICASSP2019 (2019)
Liu, Y., Pan, J., Su, Z.: Deep blind image inpainting. In: Cui, Z., Pan, J., Zhang, S., Xiao, L., Yang, J. (eds.) IScIDE 2019. LNCS, vol. 11935, pp. 128–141. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-36189-1_11
Coupé, P., Tourdias, T., Linck, P., Romero, J.E., Manjón, J.V.: LesionBrain: an online tool for white matter lesion segmentation. In: Bai, W., Sanroma, G., Wu, G., Munsell, B.C., Zhan, Y., Coupé, P. (eds.) Patch-MI 2018. LNCS, vol. 11075, pp. 95–103. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00500-9_11
Manjon, J.V., et al.: Adaptive non-local means denoising of MR images with spatially varying noise levels. J. Magn. Reson. Imaging 31(1), 192–203 (2010)
Avants, B.B., et al.: A reproducible evaluation of ANTs similarity metric performance in brain image registration. Neuroimage 54(3), 2033–2044 (2011)
Tustison, N.J., et al.: N4ITK: improved N3 bias correction. IEEE Trans. Med. Imaging 29(6), 1310–1320 (2010)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, William M., Frangi, Alejandro F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Dou, Q., Yu, L., Chen, H., Jin, Y., Yang, X., Qin, J., Heng, P.A.: 3D deeply supervised network for automated segmentation of volumetric medical images. Med. Image Anal. 41, 40–54 (2017)
Ashburner, J.: SPM: a history. Neuroimage 62(2), 791–800 (2012)
Acknowledgement
This research was supported by the Spanish DPI2017-87743-R grant from the Ministerio de Economia, Industria y Competitividad of Spain. This work also benefited from the support of the project DeepvolBrain of the French National Research Agency (ANR-18-CE45-0013). This study was achieved within the context of the Laboratory of Excellence TRAIL ANR-10-LABX-57 for the BigDataBrain project. Moreover, we thank the Investments for the future Program IdEx Bordeaux (ANR-10- IDEX- 03- 02, HL-MRI Project), Cluster of excellence CPU and the CNRS. The authors gratefully acknowledge the support of NVIDIA Corporation with their donation of the TITAN X GPU used in this research.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Manjón, J.V. et al. (2020). Blind MRI Brain Lesion Inpainting Using Deep Learning. In: Burgos, N., Svoboda, D., Wolterink, J.M., Zhao, C. (eds) Simulation and Synthesis in Medical Imaging. SASHIMI 2020. Lecture Notes in Computer Science(), vol 12417. Springer, Cham. https://doi.org/10.1007/978-3-030-59520-3_5
Download citation
DOI: https://doi.org/10.1007/978-3-030-59520-3_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-59519-7
Online ISBN: 978-3-030-59520-3
eBook Packages: Computer ScienceComputer Science (R0)