Systems Approach Based on Petri Nets as a Method for Modeling and Analysis of Complex Biological Systems Presented on the Example of Atherosclerosis Development Process | SpringerLink
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Systems Approach Based on Petri Nets as a Method for Modeling and Analysis of Complex Biological Systems Presented on the Example of Atherosclerosis Development Process

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Advanced, Contemporary Control

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 1196))

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Abstract

Living organisms, as well as their functional blocks, are complex systems. From this follows that for their deep understanding it is necessary to use systems methods for their analysis. The basis for such an analysis is a precise mathematical model. It seems that models expressed as Petri nets are especially promising in the area of modeling and analysis of biological systems. In this paper a Petri net based approach for such an analysis is presented on the example of a complex process of atherosclerosis development. Classic methods of analysis based on MCT sets and t-clusters were used. Additionally, extended methods of analysis such as significance analysis and knockout analysis were applied. Significance analysis can be used to determine which elementary subprocesses are key to the functioning of the modeled system, while knockout analysis can be used to confirm the results of the significance analysis.

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Acknowledgement

This research has been partially supported by the National Science Centre (Poland) grant No. 2012/07/B/ST6/01537 and by the statutory funds of Poznan University of Technology.

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Authors and Affiliations

  1. Institute of Computing Science, Poznan University of Technology, Piotrowo 2, 60-965, Poznan, Poland

    Kaja Gutowska & Piotr Formanowicz

  2. Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland

    Kaja Gutowska & Piotr Formanowicz

  3. Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, Rokietnicka 8, 60-806, Poznan, Poland

    Dorota Formanowicz

Authors
  1. Kaja Gutowska
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  2. Dorota Formanowicz
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  3. Piotr Formanowicz
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Corresponding author

Correspondence to Piotr Formanowicz .

Editor information

Editors and Affiliations

  1. Institute of Automatic Control, Lodz University of Technology, Lodz, Poland

    Andrzej Bartoszewicz

  2. Institute of Automatic Control, Lodz University of Technology, Lodz, Poland

    Jacek Kabziński

  3. Systems Research Institute, Polish Academy of Sciences, Warsaw, Poland

    Janusz Kacprzyk

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Gutowska, K., Formanowicz, D., Formanowicz, P. (2020). Systems Approach Based on Petri Nets as a Method for Modeling and Analysis of Complex Biological Systems Presented on the Example of Atherosclerosis Development Process. In: Bartoszewicz, A., Kabziński, J., Kacprzyk, J. (eds) Advanced, Contemporary Control. Advances in Intelligent Systems and Computing, vol 1196. Springer, Cham. https://doi.org/10.1007/978-3-030-50936-1_49

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