Abstract
Aortic stiffness is an important diagnostic and prognostic parameter for many diseases, and is estimated by measuring the Pulse Wave Velocity (PWV) from Cardiac Magnetic Resonance (CMR) images. However, this process requires combinations of multiple sequences, which makes the acquisition long and processing tedious. We propose a method for aorta segmentation and centerline extraction from para-sagittal Phase-Contrast (PC) CMR images. The method uses the order of appearance of the blood flow in PC images to track the aortic centerline from the seed start position to the seed end position of the aorta. The only required user interaction involves selection of 2 input seed points for the start and end position of the aorta. We validate our results against the ground truth manually extracted centerlines from para-sagittal PC images and anatomical MR images. The resulting measurement values of both centerline length and PWV show high accuracy and low variability, which allows for use in clinical setting. The main advantage of our method is that it requires only velocity encoded PC image, while being able to process images encoded only in one direction.
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References
Azad, Y.J., Malsam, A., Ley, S., Rengier, F., Dillmann, R., Unterhinninghofen, R.: Tensor-based tracking of the aorta in phase-contrast MR images. In: Medical Imaging 2014: Image Processing, vol. 9034, p. 90340L. International Society for Optics and Photonics (2014)
Babin, D., Pižurica, A., Philips, W.: Robust segmentation methods for aortic pulse wave velocity measurement. In: IEEE EMBS Benelux Chapter, Annual symposium, Abstracts (2011)
Babin, D., Vansteenkiste, E., Pižurica, A., Philips, W.: Segmentation and length measurement of the abdominal blood vessels in 3-D MRI images. In: Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBC 2009, pp. 4399–4402 (2009)
Babin, D., Devos, D., Pižurica, A., Westenberg, J., Vansteenkiste, E., Philips, W.: Robust segmentation methods with an application to aortic pulse wave velocity calculation. Comput. Med. Imaging Graph. 38(3), 179–189 (2014)
Brandts, A., et al.: Association of aortic arch pulse wave velocity with left ventricular mass and lacunar brain infarcts in hypertensive patients: assessment with MR imaging. Radiology 253(3), 681–688 (2009)
Devos, D.G., et al.: Proximal aortic stiffening in turner patients may be present before dilation can be detected: a segmental functional MRI study. J. Cardiovasc. Magn. Reson. 19(1), 27 (2017)
Devos, D.G., et al.: MR pulse wave velocity increases with age faster in the thoracic aorta than in the abdominal aorta. J. Magn. Reson. Imaging 41(3), 765–772 (2015)
van Elderen, S., et al.: Cerebral perfusion and aortic stiffness are independent predictors of white matter brain atrophy in type 1 diabetic patients assessed with magnetic resonance imaging. Diabetes Care 34(2), 459–463 (2011)
Fielden, S., Fornwalt, B., Jerosch-Herold, M., Eisner, R., Stillman, A., Oshinski, J.: A new method for the determination of aortic pulse wave velocity using cross-correlation on 2D PCMR velocity data. J. Magn. Reson. Imaging 27(6), 1382–1387 (2008)
Giri, S., et al.: Automated and accurate measurement of aortic pulse wave velocity using magnetic resonance imaging. In: Computers in Cardiology, pp. 661–664, October 2007
Jeong, Y.J., Ley, S., Delles, M., Dillmann, R., Unterhinninghofen, R.: Graph-based bifurcation detection in phase-contrast MR images. In: Medical Imaging 2013: Image Processing, vol. 8669, p. 86691Z. International Society for Optics and Photonics (2013)
Jeong, Y.J., Ley, S., Dillmann, R., Unterhinninghofen, R.: Vessel centerline extraction in phase-contrast MR images using vector flow information. In: Medical Imaging 2012: Image Processing, vol. 8314, p. 83143H. International Society for Optics and Photonics (2012)
Kröner, E., et al.: Evaluation of sampling density on the accuracy of aortic pulse wave velocity from velocity-encoded MRI in patients with Marfan syndrome. J. Cardiovasc. Magn. Reson. 36(6), 1470–1476 (2012)
Markl, M., Wallis, W., Brendecke, S., Simon, J., Frydrychowicz, A., Harloff, A.: Estimation of global aortic pulse wave velocity by flow-sensitive 4D MRI. Magn. Reson. Med. 63(6), 1575–1582 (2010)
Roes, S., et al.: Assessment of aortic pulse wave velocity and cardiac diastolic function in subjects with and without the metabolic syndrome. Diabetes Care 31(7), 1442–1444 (2008)
Volonghi, P., et al.: Automatic extraction of three-dimensional thoracic aorta geometric model from phase contrast MRI for morphometric and hemodynamic characterization. Magn. Reson. Med. 75(2), 873–882 (2016)
Acknowledgement
This work was supported by IWT Innovation Mandate spin-off project 130865: “WaVelocity: cardiovascular structure and flow analysis software” and by Croatian Science Foundation under the project UIP-2017-05-4968.
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Babin, D. et al. (2020). Segmentation of Phase-Contrast MR Images for Aortic Pulse Wave Velocity Measurements. In: Blanc-Talon, J., Delmas, P., Philips, W., Popescu, D., Scheunders, P. (eds) Advanced Concepts for Intelligent Vision Systems. ACIVS 2020. Lecture Notes in Computer Science(), vol 12002. Springer, Cham. https://doi.org/10.1007/978-3-030-40605-9_7
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DOI: https://doi.org/10.1007/978-3-030-40605-9_7
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