Trombin
| Trombin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.21.5 | ||||||||
| CAS broj | 2594047 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trombin (EC 3.4.21.5, trombaza, trombofort, topikal, trombin-C, tropostazin, aktivatirani krvno-koagulacioni faktor II, krvno-koagulacioni faktor IIa, faktor IIa, E trombin, beta-trombin, gama-trombin) je enzim.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Selektivno razlaganje Arg-Gly veza u fibrinogenu čime se formira fibrin i odvajaju fibrinopeptidi A i B
Ovaj enzim se formira iz protrombina.
- ↑ Baughman, D.J. (1970). „Thrombin assay”. Methods Enzymol. 19: 145-157.
- ↑ Magnusson, S. (1970). „Bovine prothrombin and thrombin”. Methods Enzymol. 19: 157-184.
- ↑ Miller, K.D. (1970). „Horse prothrombin”. Methods Enzymol. 19: 140-145.
- ↑ Lundblad, R.L., Kingdon, H.S. and Mann, K.G. (1976). „Thrombin”. Methods Enzymol. 45: 156-176. PMID 1011989.
- ↑ Mann, K.G. (1976). „Prothrombin”. Methods Enzymol. 45: 123-156. PMID 1011988.
- ↑ Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. (1979). „The role of serine proteases in the blood coagulation cascade”. Adv. Enzymol. 48: 277-318. PMID 367103.
- ↑ Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry 23: 644-650. PMID 6370301.
- ↑ MacGillivray, R.T.A. and Davie, E.W. (1984). „Characterization of bovine prothrombin mRNA and its translation product”. Biochemistry 23: 1626-1634. PMID 6326805.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.