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. 2024 Mar 27;14(1):7248.
doi: 10.1038/s41598-024-55623-3.

Association of maternal leukocyte, monocyte, and neutrophil counts with hypertensive disorders of pregnancy: the Japan Environment and Children's Study (JECS)

Shiori Ishiyama  1 , Kazuki Mochizuki  2 , Ryoji Shinohara  3 , Kunio Miyake  4 , Megumi Kushima  3 , Reiji Kojima  4 , Sayaka Horiuchi  3 , Sanae Otawa  3 , Hideki Yui  3 , Tadao Ooka  4 , Yuka Akiyama  4 , Hiroshi Yokomichi  4 , Zentaro Yamagata  5   6 ; Japan Environment and Children’s Study Group
Collaborators, Affiliations

Association of maternal leukocyte, monocyte, and neutrophil counts with hypertensive disorders of pregnancy: the Japan Environment and Children's Study (JECS)

Shiori Ishiyama et al. Sci Rep. .

Abstract

Hypertensive disorders of pregnancy (HDP) increase the risk of preterm births and cesarean delivery. This study aimed to investigate whether maternal blood leukocyte, monocyte, or neutrophil counts in the first trimester are related to the development of HDP. Data were collected from the Japan Environment and Children's Study, a large birth cohort study (n = 38,194) that recruited pregnant women in 15 Regional Centers across Japan (from January 2011 to March 2014). The odds ratios (ORs) for mild/severe HDP according to the cut-off value of leukocyte/neutrophil/monocyte counts by the receiver operating characteristic curve showed high ORs. Furthermore, pregnant women with the highest quartiles of leukocyte and monocyte counts had higher adjusted ORs (aORs) for mild (leukocyte: aOR = 1.27, 95% confidence interval [CI]: 1.02-1.58; monocyte: aOR = 1.30, 95% CI 1.04-1.63) and severe HDP (leukocyte: aOR = 1.51, 95% CI 1.08-2.13; monocyte: aOR = 1.44, 95% CI 1.03-2.01) compared with those with the lowest quartiles of those counts. In addition, pregnant women with the highest neutrophil counts had higher aOR for mild HDP (aOR = 1.26, 95% CI 1.02-1.56) compared with those with the lowest count. In conclusion, high leukocyte and monocyte counts in the first trimester are associated with the development of HDP. Thus, they may be used to predict subsequent HDP.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Outcomes of ROC curve analyses for mild HDP. (A) Leukocyte counts (cut-off value: 9000, AUC: 55.6%, sensitivity: 38.3%, specificity: 71.1%), (B) Neutrophil counts (cut-off value: 6469.5, AUC: 54.9%, sensitivity: 44.1%, specificity: 65.1%), (C) Monocyte counts (cut-off value: 336.3, AUC: 56.1%, sensitivity: 70.8%, specificity: 38.2%). AUC area under the curve, HDP Hypertensive Disorders of Pregnancy, ROC receiver operating characteristic.
Figure 2
Figure 2
Outcomes of ROC curve analyses for severe HDP. (A) Leukocyte counts (cut-off value: 9600, AUC: 56.2%, sensitivity: 29.5%, specificity: 80.2%), (B) Neutrophil counts (cut-off value: 5413.1, AUC: 55.5%, sensitivity: 71.6%, specificity: 38.7%), (C) Monocyte counts (cut-off value: 376.3, AUC: 57.1%, sensitivity: 58.4%, specificity: 53.0%). AUC area under the curve, HDP Hypertensive Disorders of Pregnancy, ROC receiver operating characteristic.
Figure 3
Figure 3
Participant inclusion flow chart.
See this image and copyright information in PMC

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