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. 2023 Jul 10;21(1):68.
doi: 10.1186/s12955-023-02156-4.

Health-related quality of life of mothers and developmental characteristics of very low birth weight children at 2.5 years of age: results from the Japan Environment and Children's Study (JECS)

Hatoko Sasaki  1   2 , Kyongsun Pak  3 , Hidetoshi Mezawa  4 , Kiwako Yamamoto-Hanada  4 , Kazue Ishitsuka  5 , Mizuho Konishi  4   6 , Minaho Nishizato  4 , Miori Sato  4 , Mayako Saito-Abe  4 , Limin Yang  4 , Yukihiro Ohya  4 ; Japan Environment, Children’s Study (JECS) Group
Affiliations

Health-related quality of life of mothers and developmental characteristics of very low birth weight children at 2.5 years of age: results from the Japan Environment and Children's Study (JECS)

Hatoko Sasaki et al. Health Qual Life Outcomes. .

Abstract

Background: The level of child development may be associated with the risk of poor maternal health-related quality of life (HRQoL). The objective of this study was to describe the developmental characteristics of very low birth weight (VLBW) children at 2.5 years of age and to examine associations between maternal HRQoL and the degree of child development based on the Japanese version of Ages and Stages Questionnaire (J-ASQ-3).

Methods: A cross-sectional study was performed using the data from a nationwide prospective birth cohort study in Japan. Among a total of 104,062 fetal records, the VLBW infants (birth weight ≤ 1500 g) were analyzed using linear regression models, adjusted for potential covariates. Subgroup analysis was also conducted to assess the association between social connection or cooperation of the partner and maternal HRQoL by the level of child development.

Results: The final study subjects included 357 VLBW children and mothers. The suspected developmental delays (SDDs) in at least two domains was significantly associated with lower maternal mental HRQoL regression coefficient -2.314 (95%CI: -4.065 to -0.564). There was no association between the status of child development and maternal physical HRQoL. After adjusting for child and maternal covariates, the maternal HRQoL was not significantly associated with child development. Amongst women who indicated having some social support, having a child with a SDD in two or more domains was negatively associated with mental HRQoL compared with women whose child was less developmental delay, regression coefficient -2.337 (95%CI: -3.961 to -0.714). Amongst women who indicated having partner's cooperation to child-rearing, having a child with a SDD in two or more domains was negatively associated with mental HRQoL compared with women whose child was less developmental delay, regression coefficient -3.785 (95%CI: -6.647 to -0.924).

Conclusions: Our findings indicate that the lower maternal mental HRQoL was independently associated with the SDDs evaluated by the J-ASQ-3, whereas there was no association after adjusting for covariates. Further research is warranted to elucidate the impact of social connection and partner's cooperation on maternal HRQoL and child development. This study urges that particular attention should be paid to mothers of VLBW children with SDDs and also to provide early intervention and continued support.

Keywords: Child development; Health-related quality of life; Japan Environment and Children’s Study (JECS); Very low birth weight.

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Conflict of interest statement

The authors declare no competing interests.

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Percentages of suspected developmental delay in J-ASQ-3 domains
Fig. 2
Fig. 2
1 Univariate regression of the association between social connection / cooperation of the partner and physical HRQoL by probability of scoring “Needs assessment” on J-ASQ-3 (The arrows of confidence intervals indicate the wide range of upper or lower limit.). 2: Univariate regression of the association between social connection / cooperation of the partner and mental HRQoL by probability of scoring “Needs assessment” on J-ASQ-3 (The arrows of confidence intervals indicate the wide range of upper or lower limit.)
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