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. 2022 Dec 28;12(1):22488.
doi: 10.1038/s41598-022-26748-0.

Prevalence of infectious diseases in preterm infants: a 2-year follow-up from the Japan Environment and Children's Study

Kentaro Tamura  1 , Kenta Matsumura  2   3 , Akiko Tsuchida  2   3 , Taketoshi Yoshida  4 , Hidekuni Inadera  2   3 ; Japan Environment and Children’s Study (JECS) Group
Collaborators, Affiliations

Prevalence of infectious diseases in preterm infants: a 2-year follow-up from the Japan Environment and Children's Study

Kentaro Tamura et al. Sci Rep. .

Abstract

Evidence regarding the long-term risk of infections in preterm infants is lacking. In this study, we examined whether preterm infants developed various common childhood infections more frequently than full-term infants by the age of 2 years by analyzing data from a questionnaire completed by 67,282 mother-toddler pairs in a nationwide birth cohort study. Of the target population, 2885 (4.3%) were born prematurely. After covariate adjustment for maternal and children factors, lower respiratory tract infections appeared more frequent in preterm than in full-term infants at both 1 and 2 years (adjusted odds ratio [aOR] 1.21, 95% confidence interval [CI] 1.05-1.41, and aOR 1.27, 95% CI 1.11-1.46, respectively). However, there was no significant difference in the frequencies of lower respiratory tract infection between preterm and full-term infants after Palivizumab administration. The risk of other common infections, such as in the upper respiratory tract infection, otitis media, urinary tract infection, gastroenteritis, herpangina, hand-foot-and-mouth disease, chickenpox, influenza virus, and adenovirus infections, was not higher in preterm than in full-term infants after covariates adjustment for maternal and children factors. These findings suggest Palivizumab prophylaxis could reduce the frequencies of lower respiratory tract infection in preterm to the same level as in full-term infants.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Participant flow diagram. Flow diagram of the recruitment and exclusion process for participants.
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References

    1. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75–84. doi: 10.1016/S0140-6736(08)60074-4. - DOI - PMC - PubMed
    1. Vital statistics, Ministry of Health, Labour and Welfare, Japan. https://www.mhlw.go.jp/toukei/list/81-1a.html (2022)
    1. Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390:1770–1780. doi: 10.1016/s0140-6736(17)31002-4. - DOI - PubMed
    1. Kramer MS, et al. The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. JAMA. 2000;284:843–849. doi: 10.1001/jama.284.7.843. - DOI - PubMed
    1. Houweling LM, et al. First year of life medication use and hospital admission rates: premature compared with term infants. J. Pediatr. 2013;163:61–66. doi: 10.1016/j.jpeds.2012.12.014. - DOI - PubMed

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