Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children's Study - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 5;22(1):542.
doi: 10.1186/s12884-022-04861-2.

Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children's Study

Hyo Kyozuka  1   2 , Tsuyoshi Murata  3   4 , Toma Fukuda  3   4 , Karin Imaizumi  3   4 , Akiko Yamaguchi  3   4 , Shun Yasuda  3   4 , Daisuke Suzuki  4   5 , Akiko Sato  4 , Yuka Ogata  4 , Mitsuaki Hosoya  4   6 , Seiji Yasumura  4   7 , Koichi Hashimoto  4   6 , Hidekazu Nishigori  4   5 , Keiya Fujimori  3   4 ; Japan Environment, Children’s Study (JECS) Group
Collaborators, Affiliations

Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children's Study

Hyo Kyozuka et al. BMC Pregnancy Childbirth. .

Abstract

Background: In reproductive medicine, vitamin D (VitD) is of particular interest because its deficiency has been linked to various infertility issues. Thus, preconception care, including appropriate VitD supplementation, is essential, especially in women using assisted reproductive technology (ART). Despite the therapeutic benefits of VitD, adverse events due to a high daily intake may influence obstetric outcomes. However, the effects of either low or high preconception VitD intake on obstetric outcomes, including the outcomes in women who used ART, remain unclear. Therefore, the aim of this study was to examine the association between pre-pregnancy daily VitD intake and obstetric outcomes in Japanese women, including those who conceived through ART.

Methods: Data were obtained from the Japan Environment and Children's study database comprising 92,571 women recruited between January 2011 and March 2014 in Japan. Participants were categorized into five quintiles according to pre-pregnancy VitD intake (Q1 and Q5 had the lowest and highest VitD intake, respectively) and stratified according to the use of ART. Multiple logistic regression was performed to identify the effects of pre-pregnancy VitD intake on preterm birth (PTB), low-birth weight infant (LBW), and small for gestational age (SGA).

Results: Using Q3 (middle VitD intake) as a reference, our analysis revealed that Q5 (highest VitD intake) showed an increased risk of LBW < 1500 g (adjusted odds ratio [aOR]: 1.09, 95% confidence interval [CI]: 1.00-1.18) and SGA (aOR: 1.26, 95% CI: 1.14-1.39) among women who conceived without ART. Among women who conceived with ART, we found that Q5 (highest VitD intake) showed an increased risk of PTB at < 37 weeks (aOR: 2.05, 95% CI: 1.27-3.31).

Conclusion: The present study revealed that higher VitD intake before pregnancy may affect perinatal outcomes, particularly in women using ART. Our findings may facilitate personalized preconceptional counseling regarding VitD intake based on the method of conception, especially among women using ART.

Keywords: Gestational age; Preconception care; Pregnancy; Premature birth; Vitamin D.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study flow chart. ART: Assisted reproductive technology
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Milart J, Lewicka A, Jobs K, Wawrzyniak A, Majder-Łopatka M, Kalicki B. Effect of vitamin D treatment on dynamics of stones formation in the urinary tract and bone density in children with idiopathic hypercalciuria. Nutrients. 2020;12:2521. doi: 10.3390/nu12092521. - DOI - PMC - PubMed
    1. Petrelli F, Luciani A, Perego G, Dognini G, Colombelli PL, Ghidini A. Therapeutic and prognostic role of vitamin D for COVID-19 infection: a systematic review and meta-analysis of 43 observational studies. J Steroid Biochem Mol Biol. 2021;211:105883. doi: 10.1016/j.jsbmb.2021.105883. - DOI - PMC - PubMed
    1. Iliuta F, Pijoan JI, Lainz L, Exposito A, Matorras R. Women’s vitamin D levels and IVF results: a systematic review of the literature and meta-analysis, considering three categories of vitamin status (replete, insufficient and deficient) Hum Fertil (Camb) 2020;14:1–19. doi: 10.1080/14647273.2020.1807618. - DOI - PubMed
    1. Dabrowski FA, Grzechocinska B, Wielgos M. The role of vitamin D in reproductive health-a Trojan horse or the Golden Fleece? Nutrients. 2015;7:4139–4153. doi: 10.3390/nu7064139. - DOI - PMC - PubMed
    1. Zhao J, Huang X, Xu B, Yan Y, Zhang Q, Li Y. Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2018;16:13. doi: 10.1186/s12958-018-0324-3. - DOI - PMC - PubMed

LinkOut - more resources