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. 2022 Jul;71(3):335-344.
doi: 10.1016/j.alit.2022.01.002. Epub 2022 Feb 24.

Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort

Makoto Irahara  1 , Kiwako Yamamoto-Hanada  2 , Mayako Saito-Abe  1 , Miori Sato  1 , Yumiko Miyaji  1 , Limin Yang  1 , Hiroshi Mitsubuchi  3 , Masako Oda  4 , Masafumi Sanefuji  5 , Shouichi Ohga  5 , Akihiko Ikegami  6 , Nathan Mise  6 , Reiko Suga  7 , Masayuki Shimono  7 , Shin Yamazaki  8 , Shoji F Nakayama  8 , Yukihiro Ohya  1
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Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort

Makoto Irahara et al. Allergol Int. 2022 Jul.
Free article

Abstract

Background: Allergen-specific immunoglobulins have a crucial role in allergic diseases. Most wheeze episodes develop before school age, and allergic rhinitis later develops during early elementary school years. However, the clinical background and cytokine/chemokine profiles associated with changes in immunoglobulins during early school-age are poorly understood.

Methods: This study used blood samples from children participating in the JECS Pilot Study. We examined nineteen kinds of aeroallergen-specific immunoglobulins (IgE, IgG1, IgG4, and IgA) levels in patients at age 6 and age 8. Fluctuations of Der f 1- and Cry j 1-specific immunoglobulins levels during the two periods were compared to assess the frequency of allergic statuses and clusters of cytokine/chemokine profiles.

Results: The medians of aeroallergen-specific IgE levels did not fluctuate, and almost all IgG1 and IgG4 decreased. In IgA, four (e.g., Der f 1) increased, whereas the other four (e.g., Cry j 1) decreased. The ratio of the Der f 1-specific IgG1 level at age 8 to that at age 6 was higher in children with poor asthma control than in children with better asthma control. Moreover, the cytokine/chemokine cluster with relatively lower IL-33 and higher CXCL7/NAP2 was associated with lower Der f 1- and Cry j 1-specific IgG4 levels, but not IgE levels.

Conclusions: The cluster of cytokine/chemokine profiles characterized by lower IL-33 and higher CXCL7/NAP2 was associated with the maintenance of aeroallergen-specific IgG4 levels. This result provides a basis for considering the control of aeroallergen-specific immunoglobulins.

Keywords: Chemokine; Der f 1; IgE; IgG4; Interleukin.

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