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. 2022 May;13(5):889-899.
doi: 10.1111/jdi.13723. Epub 2021 Dec 22.

Association between pre-pregnancy body mass index and gestational weight gain and perinatal outcomes in pregnant women diagnosed with gestational diabetes mellitus: The Japan Environment and Children's Study

Yoshihiro Saito  1 , Sumitaka Kobayashi  2 , Atsuko Ikeda-Araki  2   3 , Sachiko Ito  2 , Chihiro Miyashita  2 , Takashi Kimura  4 , Takumi Hirata  4 , Akiko Tamakoshi  4 , Michinori Mayama  1 , Kiwamu Noshiro  1 , Kinuko Nakagawa  1 , Takeshi Umazume  1 , Kentaro Chiba  1 , Satoshi Kawaguchi  1 , Mamoru Morikawa  1 , Kazutoshi Cho  5 , Hidemichi Watari  1 , Yoshiya Ito  6 , Yasuaki Saijo  7 , Reiko Kishi  2 ; Japan Environment and Children's Study (JECS) group
Collaborators, Affiliations

Association between pre-pregnancy body mass index and gestational weight gain and perinatal outcomes in pregnant women diagnosed with gestational diabetes mellitus: The Japan Environment and Children's Study

Yoshihiro Saito et al. J Diabetes Investig. 2022 May.

Abstract

Aims/introduction: We investigated the association between gestational diabetes mellitus (GDM) and perinatal outcomes stratified by pre-pregnancy body mass index (BMI) and/or gestational weight gain (GWG).

Materials and methods: Data from the national birth cohort in the Japan Environment and Children's Study from 2011 to 2014 (n = 85,228) were used. Japan uses the GDM guidelines of the International Association of Diabetes and Pregnancy Study Groups. The odds ratios (ORs) of perinatal outcomes were compared between women with and those without GDM.

Results: The OR (95% confidence interval) of having a small for gestational age infant in the GDM group with a pre-pregnancy BMI of ≥25.0 kg/m2 and insufficient GWG (<2.75 kg) was 1.78 (1.02-3.12). The OR of having a large for gestational age infant of the same BMI group with excessive GWG (>7.25 kg) was 2.04 (1.56-2.67). The OR of hypertensive disorders of pregnancy was higher in women with a BMI ≥18.5 kg/m2 in the GDM group than in the non-GDM group.

Conclusions: Large for gestational age and hypertensive disorders of pregnancy were associated with pre-pregnancy BMI and GWG in either normal weight or overweight/obese women, and the relationship was strengthened when GDM was present. Women with GDM and a BMI of ≥25.0 kg/m2 are at risk of having small for gestational age and large for gestational age infants depending on GWG.

Keywords: Body mass index; Gestational diabetes mellitus; Gestational weight gain.

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Figures

Figure 1
Figure 1
Flowchart of the selected participants. DMT1, type 1 diabetes; DMT2, type 2diabetes; Dr‐0m, medical records provided by a doctor or medical staff at birth; Dr‐T1, medical records provided by a doctor or medical staff in the first trimester; GDM, gestational diabetes mellitus; M‐T1, self‐administered questionnaires for mothers in the first trimester.
Figure 2
Figure 2
(a) Cumulative bar chart of the participants' gestational weight gain (GWG) stratified by pre‐pregnancy body mass index (BMI) in the Japanese Ministry of Health, Labor and Welfare (MHLW) classification. (b) Cumulative bar chart of the participants' GWGs stratified by pre‐pregnancy BMI in the Institute of Medicine (IOM) classification. GDM, gestational diabetes mellitus.
See this image and copyright information in PMC

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