Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children's Study (JECS)

doi:10.1186/s12887-021-02885-9

. 2021 Sep 23;21(1):419.

doi: 10.1186/s12887-021-02885-9.

Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children's Study (JECS)

Collaborators, Affiliations

Collaborators

Japan Environment and Children’s Study Group:
Michihiro Kamijima, Shin Yamazaki, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Takeo Nakayama, Hiroyasu Iso, Masayuki Shima, Youichi Kurozawa, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh

Affiliations

¹ Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan.
² Toyama Regional Center for JECS, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-8555, Japan.
³ Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan.
⁴ Department of Public Health, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi City, Gunma, 371-8511, Japan.
⁵ Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan. inadera@med.u-toyama.ac.jp.
⁶ Toyama Regional Center for JECS, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-8555, Japan. inadera@med.u-toyama.ac.jp.

PMID: 34556067
PMCID: PMC8459474
DOI: 10.1186/s12887-021-02885-9

Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children's Study (JECS)

Mari Nakamura et al. BMC Pediatr. 2021.

. 2021 Sep 23;21(1):419.

doi: 10.1186/s12887-021-02885-9.

Authors

Collaborators

Japan Environment and Children’s Study Group:
Michihiro Kamijima, Shin Yamazaki, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Takeo Nakayama, Hiroyasu Iso, Masayuki Shima, Youichi Kurozawa, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh

Affiliations

¹ Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan.
² Toyama Regional Center for JECS, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-8555, Japan.
³ Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan.
⁴ Department of Public Health, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi City, Gunma, 371-8511, Japan.
⁵ Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan. inadera@med.u-toyama.ac.jp.
⁶ Toyama Regional Center for JECS, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-8555, Japan. inadera@med.u-toyama.ac.jp.

PMID: 34556067
PMCID: PMC8459474
DOI: 10.1186/s12887-021-02885-9

Abstract

Background: The association between delivery mode and subsequent development of diseases is a growing area of research. Cesarean delivery affects the diversity of the microbiota in the infant gut, which may be associated with gastrointestinal disorders, including functional constipation, in infants. In this study, we investigated the association between delivery mode and prevalence of functional constipation in 3-year-old Japanese toddlers.

Methods: This study used data from the Japan Environment and Children's Study, an ongoing nationwide birth cohort study. We analyzed 71,878 toddler-mother pairs. The presence of functional constipation was determined according to the Rome III diagnostic criteria. Odds ratios and 95% confidence intervals were calculated using logistic regression analysis.

Results: The prevalence of functional constipation in 3-year-old Japanese toddlers was estimated to be 12.3%. Logistic regression analysis revealed that the prevalence of functional constipation was higher in toddlers born by cesarean delivery (13.1%) compared with those born by vaginal delivery (12.1%), independent of 22 confounders (adjusted odds ratios = 1.064, 95% confidence interval = 1.004-1.128).

Conclusions: We determined the prevalence of functional constipation in 3-year-old Japanese toddlers and found that delivery mode was associated with the prevalence of functional constipation in Japanese toddlers.

Keywords: Birth cohort; Cesarean section; Delivery mode; Functional constipation.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

See this image and copyright information in PMC

Cited by

Impact of breastfeeding during infancy on functional constipation at 3 years of age: the Japan Environment and Children's Study.
Motoki N, Inaba Y, Toubou H, Hasegawa K, Shibazaki T, Tsukahara T, Nomiyama T; Japan Environment and Children’s Study (JECS) Group. Motoki N, et al. Int Breastfeed J. 2023 Nov 6;18(1):57. doi: 10.1186/s13006-023-00592-y. Int Breastfeed J. 2023. PMID: 37926840 Free PMC article.
The ten "hard" questions in pediatric functional constipation.
Fedele F, Fioretti MT, Scarpato E, Martinelli M, Strisciuglio C, Miele E. Fedele F, et al. Ital J Pediatr. 2024 Apr 8;50(1):64. doi: 10.1186/s13052-024-01623-y. Ital J Pediatr. 2024. PMID: 38649896 Free PMC article. Review.
Hypertensive disorders of pregnancy increase the incidence of febrile seizures in offspring.
Yabe M, Fukuyama T, Motoki N, Toubou H, Hasegawa K, Shibazaki T, Tsukahara T, Nomiyama T; Japan Environment and Children’s Study (JECS) Group. Yabe M, et al. Pediatr Res. 2024 Jul;96(1):223-229. doi: 10.1038/s41390-024-03057-y. Epub 2024 Feb 3. Pediatr Res. 2024. PMID: 38310196
Constipation: A Pristine Universal Pediatric Health Delinquent.
Chowdhury K, Sinha S, Kumar S, Haque M, Ahmad R. Chowdhury K, et al. Cureus. 2024 Jan 19;16(1):e52551. doi: 10.7759/cureus.52551. eCollection 2024 Jan. Cureus. 2024. PMID: 38249647 Free PMC article. Review.
Cesarean section and parenting stress: Results from the Japan Environment and Children's Study.
Matsumura K, Hatakeyama T, Yoshida T, Tsuchida A, Inadera H; Japan Environment and Children’s Study (JECS) Group. Matsumura K, et al. Eur Psychiatry. 2023 Jan 24;66(1):e18. doi: 10.1192/j.eurpsy.2023.5. Eur Psychiatry. 2023. PMID: 36691785 Free PMC article.

See all "Cited by" articles

References

1. Kuhle S, Tong OS, Woolcott CG. Association between caesarean section and childhood obesity: a systematic review and meta-analysis. Obes Rev. 2015;16(4):295–303. doi: 10.1111/obr.12267. - DOI - PubMed
1. Kristensen K, Henriksen L. Cesarean section and disease associated with immune function. J Allergy Clin Immunol. 2016;137(2):587–590. doi: 10.1016/j.jaci.2015.07.040. - DOI - PubMed
1. Bager P, Simonsen J, Nielsen NM, Frisch M. Cesarean section and offspring's risk of inflammatory bowel disease: a national cohort study. Inflamm Bowel Dis. 2012;18(5):857–862. doi: 10.1002/ibd.21805. - DOI - PubMed
1. Decker E, Engelmann G, Findeisen A, Gerner P, Laass M, Ney D, Posovszky C, Hoy L, Hornef MW. Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children. Pediatrics. 2010;125(6):e1433–e1440. doi: 10.1542/peds.2009-2260. - DOI - PubMed
1. Cardwell CR, Stene LC, Joner G, Cinek O, Svensson J, Goldacre MJ, Parslow RC, Pozzilli P, Brigis G, Stoyanov D, et al. Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Diabetologia. 2008;51(5):726–735. doi: 10.1007/s00125-008-0941-z. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Kuhle S, Tong OS, Woolcott CG. Association between caesarean section and childhood obesity: a systematic review and meta-analysis. Obes Rev. 2015;16(4):295–303. doi: 10.1111/obr.12267. - DOI - PubMed

[2] Kuhle S, Tong OS, Woolcott CG. Association between caesarean section and childhood obesity: a systematic review and meta-analysis. Obes Rev. 2015;16(4):295–303. doi: 10.1111/obr.12267. - DOI - PubMed

[3] Kristensen K, Henriksen L. Cesarean section and disease associated with immune function. J Allergy Clin Immunol. 2016;137(2):587–590. doi: 10.1016/j.jaci.2015.07.040. - DOI - PubMed

[4] Kristensen K, Henriksen L. Cesarean section and disease associated with immune function. J Allergy Clin Immunol. 2016;137(2):587–590. doi: 10.1016/j.jaci.2015.07.040. - DOI - PubMed

[5] Bager P, Simonsen J, Nielsen NM, Frisch M. Cesarean section and offspring's risk of inflammatory bowel disease: a national cohort study. Inflamm Bowel Dis. 2012;18(5):857–862. doi: 10.1002/ibd.21805. - DOI - PubMed

[6] Bager P, Simonsen J, Nielsen NM, Frisch M. Cesarean section and offspring's risk of inflammatory bowel disease: a national cohort study. Inflamm Bowel Dis. 2012;18(5):857–862. doi: 10.1002/ibd.21805. - DOI - PubMed

[7] Decker E, Engelmann G, Findeisen A, Gerner P, Laass M, Ney D, Posovszky C, Hoy L, Hornef MW. Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children. Pediatrics. 2010;125(6):e1433–e1440. doi: 10.1542/peds.2009-2260. - DOI - PubMed

[8] Decker E, Engelmann G, Findeisen A, Gerner P, Laass M, Ney D, Posovszky C, Hoy L, Hornef MW. Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children. Pediatrics. 2010;125(6):e1433–e1440. doi: 10.1542/peds.2009-2260. - DOI - PubMed

[9] Cardwell CR, Stene LC, Joner G, Cinek O, Svensson J, Goldacre MJ, Parslow RC, Pozzilli P, Brigis G, Stoyanov D, et al. Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Diabetologia. 2008;51(5):726–735. doi: 10.1007/s00125-008-0941-z. - DOI - PubMed

[10] Cardwell CR, Stene LC, Joner G, Cinek O, Svensson J, Goldacre MJ, Parslow RC, Pozzilli P, Brigis G, Stoyanov D, et al. Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Diabetologia. 2008;51(5):726–735. doi: 10.1007/s00125-008-0941-z. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children's Study (JECS)

Collaborators

Affiliations

Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children's Study (JECS)

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Medical