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. 2021 Jul 30;11(1):15522.
doi: 10.1038/s41598-021-93101-2.

Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children's Study

Naho Morisaki  1 , Aurélie Piedvache  1 , Chie Nagata  2 , Takehiro Michikawa  3 , Seiichi Morokuma  4 , Kiyoko Kato  5 , Masafumi Sanefuji  6 , Eiji Shibata  7 , Mayumi Tsuji  8 , Masayuki Shimono  7 , Shouichi Ohga  9 , Koichi Kusuhara  10 ; Japan Environment and Children’s Study Group
Collaborators, Affiliations

Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children's Study

Naho Morisaki et al. Sci Rep. .

Abstract

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), are three reportedly predictive biomarkers that reflect subclinical chronic inflammatory burden. However, how these biomarkers change during pregnancy and its clinical utility among pregnant women have been rarely studied. Among 76,853 singleton pregnancies delivered at 28-41 weeks of gestation that were enrolled in the Japan Environment and Children's Study, we observed the distribution of maternal NLR, PLR, and LMR values from week 0 to week 36 using spline curves, as well as their predictive values for preterm delivery with and without hypertensive disorders in pregnancy, placental abruption and intrauterine growth restriction (collectively termed ischemic placental disease due to their shared pathological and pathophysiological features) for measurements at 8-11 weeks, 12-17 weeks, and 18-21 weeks. NLR and PLR increased, whereas LMR decreased, with increasing gestation. High LMR and low NLR observed at 18-21 weeks, but not at earlier gestations, were associated with higher risk of preterm delivery with IPD (odds ratio 1.80 [95% CI 1.02, 3.19] per log[LMR]; odds ratio 0.49 [95% CI 0.29, 0.82] per log[NLR]). All parameters were not predictive of preterm delivery without IPD. We provide a robust reference curve for maternal blood count parameters NLR, PLR, and LMR by gestational week.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Distribution (median + IQR) and predicted values of each biomarker among all gestations (right) and preterm delivery (left).
Figure 2
Figure 2
Risk of preterm delivery by blood count parameters. Reference is set at median of observed values of each parameter at each timepoint.
See this image and copyright information in PMC

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