Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)

doi:10.1016/j.scitotenv.2021.148643

. 2021 Nov 10:794:148643.

doi: 10.1016/j.scitotenv.2021.148643. Epub 2021 Jun 24.

Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)

Hiroko Nakaoka¹, Aya Hisada², Daisuke Matsuzawa³, Midori Yamamoto², Chisato Mori⁴; Japan Environment and Children's Study (JECS) Group; Michihiro Kamijima⁵, Shin Yamazaki⁶, Yukihiro Ohya⁷, Reiko Kishi⁸, Nobuo Yaegashi⁹, Koichi Hashimoto¹⁰, Chisato Mori¹¹, Shuichi Ito¹², Zentaro Yamagata¹³, Hidekuni Inadera¹⁴, Takeo Nakayama¹⁵, Hiroyasu Iso¹⁶, Masayuki Shima¹⁷, Youichi Kurozawa¹⁸, Narufumi Suganuma¹⁹, Koichi Kusuhara²⁰, Takahiko Katoh²¹

Affiliations

¹ Centre for Preventive Medical Sciences, Chiba University, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan. Electronic address: hnakaoka@faculty.chiba-u.jp.
² Centre for Preventive Medical Sciences, Chiba University, Japan.
³ Research Center for Child Mental Development, Chiba University, Japan.
⁴ Centre for Preventive Medical Sciences, Chiba University, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan.
⁵ Nagoya City University, Nagoya, Japan.
⁶ National Institute for Environmental Studies, Tsukuba, Japan.
⁷ National Center for Child Health and Development, Tokyo, Japan.
⁸ Hokkaido University, Sapporo, Japan.
⁹ Tohoku University, Sendai, Japan.
¹⁰ Fukushima Medical University, Fukushima, Japan.
¹¹ Chiba University, Chiba, Japan.
¹² Yokohama City University, Yokohama, Japan.
¹³ University of Yamanashi, Chuo, Japan.
¹⁴ University of Toyama, Toyama, Japan.
¹⁵ Kyoto University, Kyoto, Japan.
¹⁶ Osaka University, Suita, Japan.
¹⁷ Hyogo College of Medicine, Nishinomiya, Japan.
¹⁸ Tottori University, Yonago, Japan.
¹⁹ Kochi University, Nankoku, Japan.
²⁰ University of Occupational and Environmental Health, Kitakyushu, Japan.
²¹ Kumamoto University, Kumamoto, Japan.

PMID: 34198080
DOI: 10.1016/j.scitotenv.2021.148643

Free article

Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)

Hiroko Nakaoka et al. Sci Total Environ. 2021.

Free article

. 2021 Nov 10:794:148643.

doi: 10.1016/j.scitotenv.2021.148643. Epub 2021 Jun 24.

Authors

Affiliations

¹ Centre for Preventive Medical Sciences, Chiba University, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan. Electronic address: hnakaoka@faculty.chiba-u.jp.
² Centre for Preventive Medical Sciences, Chiba University, Japan.
³ Research Center for Child Mental Development, Chiba University, Japan.
⁴ Centre for Preventive Medical Sciences, Chiba University, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan.
⁵ Nagoya City University, Nagoya, Japan.
⁶ National Institute for Environmental Studies, Tsukuba, Japan.
⁷ National Center for Child Health and Development, Tokyo, Japan.
⁸ Hokkaido University, Sapporo, Japan.
⁹ Tohoku University, Sendai, Japan.
¹⁰ Fukushima Medical University, Fukushima, Japan.
¹¹ Chiba University, Chiba, Japan.
¹² Yokohama City University, Yokohama, Japan.
¹³ University of Yamanashi, Chuo, Japan.
¹⁴ University of Toyama, Toyama, Japan.
¹⁵ Kyoto University, Kyoto, Japan.
¹⁶ Osaka University, Suita, Japan.
¹⁷ Hyogo College of Medicine, Nishinomiya, Japan.
¹⁸ Tottori University, Yonago, Japan.
¹⁹ Kochi University, Nankoku, Japan.
²⁰ University of Occupational and Environmental Health, Kitakyushu, Japan.
²¹ Kumamoto University, Kumamoto, Japan.

PMID: 34198080
DOI: 10.1016/j.scitotenv.2021.148643

Abstract

In recent years, there has been an increase in the number of problems associated with neurodevelopmental disorders in children, and there has been a growing interest in the relationship between environmental chemicals and children's health. The objective of this study was to examine whether an association exists between occupational or environmental prenatal maternal exposure to volatile organic compounds and the risk of neurodevelopmental disorders in children using Japanese translations of the Ages & Stages Questionnaires, Third Edition (J-ASQ-3). An increase in the risk of neurodevelopmental delay in 12-month-old children associated with maternal exposure to formalin or formaldehyde was identified in terms of problem-solving (odds ratio (OR): 1.76, 95% confidence interval (CI): 0.99-3.12) and personal-social skills (OR: 3.32, 95% CI: 1.46-7.55). It is not clear whether or not this tendency is reversible, and whether it is observed past 12 months of age. Further research and a preventive approach are needed.

Keywords: Ages & Stages questionnaire; Cohort study; Formalin/formaldehyde; Neurodevelopmental disorder; Prenatal exposure.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)

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Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)

Authors

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Abstract

Conflict of interest statement

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