Digital Slides as an Effective Tool for Programmed Death Ligand 1 Combined Positive Score Assessment and Training: Lessons Learned from the "Programmed Death Ligand 1 Key Learning Program in Head-and-Neck Squamous Cell Carcinoma"

doi:10.4103/jpi.jpi_63_20

. 2021 Jan 8:12:1.

doi: 10.4103/jpi.jpi_63_20. eCollection 2021.

Digital Slides as an Effective Tool for Programmed Death Ligand 1 Combined Positive Score Assessment and Training: Lessons Learned from the "Programmed Death Ligand 1 Key Learning Program in Head-and-Neck Squamous Cell Carcinoma"

Affiliations

¹ Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
² Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
³ Division of Pathology, IEO European Institute of Oncology, Milan, Italy.
⁴ Division of Pathology, Central Hospital Bolzano, Bolzano, Italy.
⁵ Pathology Unit, Foundation IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
⁶ Division of Anatomic Pathology and Histology, Catholic University, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
⁷ Department of Molecular Medicine, Unit of Pathology, University of Pavia, Foundation IRCCS Policlinico S. Matteo, Pavia, Italy.
⁸ Department of Pathology, Clinical Labs, University of Michigan, Ann Arbor, MI, USA.
⁹ Department of Pathology, Wexner Medical Center, Ohio State University, Columbus, OH, USA.
¹⁰ Global Studio - Congresses, Convention and Incentives, Milan, Italy.
¹¹ Department of Public Health, University of Naples Federico II, Naples, Italy.

PMID: 34012705
PMCID: PMC8112335
DOI: 10.4103/jpi.jpi_63_20

Digital Slides as an Effective Tool for Programmed Death Ligand 1 Combined Positive Score Assessment and Training: Lessons Learned from the "Programmed Death Ligand 1 Key Learning Program in Head-and-Neck Squamous Cell Carcinoma"

Albino Eccher et al. J Pathol Inform. 2021.

. 2021 Jan 8:12:1.

doi: 10.4103/jpi.jpi_63_20. eCollection 2021.

Authors

Affiliations

¹ Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
² Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
³ Division of Pathology, IEO European Institute of Oncology, Milan, Italy.
⁴ Division of Pathology, Central Hospital Bolzano, Bolzano, Italy.
⁵ Pathology Unit, Foundation IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
⁶ Division of Anatomic Pathology and Histology, Catholic University, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
⁷ Department of Molecular Medicine, Unit of Pathology, University of Pavia, Foundation IRCCS Policlinico S. Matteo, Pavia, Italy.
⁸ Department of Pathology, Clinical Labs, University of Michigan, Ann Arbor, MI, USA.
⁹ Department of Pathology, Wexner Medical Center, Ohio State University, Columbus, OH, USA.
¹⁰ Global Studio - Congresses, Convention and Incentives, Milan, Italy.
¹¹ Department of Public Health, University of Naples Federico II, Naples, Italy.

PMID: 34012705
PMCID: PMC8112335
DOI: 10.4103/jpi.jpi_63_20

No abstract available

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Conflict of interest statement

There are no conflicts of interest.

Figures

**Figure 1**
Programmed death-ligand 1 immunostaining of head and neck squamous cell carcinoma. Representative staining of tumor cells (a and b) and inflammatory cells (c and d) is shown at ×20. The combined positive score of the cases were 100, 85, 80 and 27 respectively

See this image and copyright information in PMC

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[1] Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. - PubMed

[2] Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. - PubMed

[3] Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer. 2011;11:9–22. - PubMed

[4] Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer. 2011;11:9–22. - PubMed

[5] Horton JD, Knochelmann HM, Day TA, Paulos CM, Neskey DM. Immune evasion by head and neck cancer: Foundations for combination therapy. Trends Cancer. 2019;5:208–32. - PMC - PubMed

[6] Horton JD, Knochelmann HM, Day TA, Paulos CM, Neskey DM. Immune evasion by head and neck cancer: Foundations for combination therapy. Trends Cancer. 2019;5:208–32. - PMC - PubMed

[7] Cramer JD, Burtness B, Ferris RL. Immunotherapy for head and neck cancer: Recent advances and future directions. Oral Oncol. 2019;99:104460. - PMC - PubMed

[8] Cramer JD, Burtness B, Ferris RL. Immunotherapy for head and neck cancer: Recent advances and future directions. Oral Oncol. 2019;99:104460. - PMC - PubMed

[9] Pagni F, Guerini-Rocco E, Schultheis AM, Grazia G, Rijavec E, Ghidini M, et al. Targeting immune-related biological processes in solid tumors: We do need biomarkers. Int J Mol Sci. 2019;20:5452. - PMC - PubMed

[10] Pagni F, Guerini-Rocco E, Schultheis AM, Grazia G, Rijavec E, Ghidini M, et al. Targeting immune-related biological processes in solid tumors: We do need biomarkers. Int J Mol Sci. 2019;20:5452. - PMC - PubMed

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Digital Slides as an Effective Tool for Programmed Death Ligand 1 Combined Positive Score Assessment and Training: Lessons Learned from the "Programmed Death Ligand 1 Key Learning Program in Head-and-Neck Squamous Cell Carcinoma"

Affiliations

Digital Slides as an Effective Tool for Programmed Death Ligand 1 Combined Positive Score Assessment and Training: Lessons Learned from the "Programmed Death Ligand 1 Key Learning Program in Head-and-Neck Squamous Cell Carcinoma"

Authors

Affiliations

Conflict of interest statement

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References

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