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. 2021 Jul;66(7):671-679.
doi: 10.1038/s10038-020-00894-7. Epub 2021 Jan 25.

Participant mothers' attitudes toward genetic analysis in a birth cohort study

Midori Yamamoto  1 , Kenichi Sakurai  2 , Chisato Mori  3   4 , Akira Hata  3   5
Affiliations

Participant mothers' attitudes toward genetic analysis in a birth cohort study

Midori Yamamoto et al. J Hum Genet. 2021 Jul.

Abstract

To conduct a long-term birth cohort study that includes genetic analysis, it is crucial to understand the attitudes of participants to genetic analysis and then take appropriate approaches for addressing their ambiguous and negative attitudes. This study aimed to explore participants' attitudes toward genetic analysis and associated background factors among mothers who were enrolled in a large Japanese birth cohort. A questionnaire was sent to participants' households, and the responses of 1762 mothers (34.0%) were used for the study. The majority of mothers recognized genetic analysis for themselves and their children and sharing of genetic data as beneficial. A low knowledge level of genomic terminology was associated with ambiguous attitudes toward genetic analysis and data sharing. Education level was positively associated with the recognition of the benefits of genetic analysis. Concern about handling genetic information was associated with the unacceptability of data sharing. Trust was associated with the approval of genetic analysis. Most mothers preferred that genetic analysis results be returned. These findings suggest the need for multiple efforts to maximize participants' acceptance of genetic analysis, such as utilizing an educational approach to encourage familiarity with genetics/genomics, optimizing explanations for different educational levels, and explicitly disclosing the handling policy for genetic information.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
The path models for the relationship between approving attitude toward genetic analysis and background factors
Fig. 2
Fig. 2
Preference for the method of explanation about genetic analysis. Data of those who answered “I don’t know” or did not answer about the method of explanation were not shown
See this image and copyright information in PMC

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