Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future
- PMID: 31437453
- DOI: 10.1016/j.neuron.2019.05.041
Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future
Abstract
Spike-timing-dependent synaptic plasticity (STDP) is a leading cellular model for behavioral learning and memory with rich computational properties. However, the relationship between the millisecond-precision spike timing required for STDP and the much slower timescales of behavioral learning is not well understood. Neuromodulation offers an attractive mechanism to connect these different timescales, and there is now strong experimental evidence that STDP is under neuromodulatory control by acetylcholine, monoamines, and other signaling molecules. Here, we review neuromodulation of STDP, the underlying mechanisms, functional implications, and possible involvement in brain disorders.
Keywords: STDP; attention; disease; long-term depression; long-term potentiation; memory; neurodevelopment; neuromodulation; reinforcement learning; sleep; spike-timing-dependent plasticity; synaptic plasticity.
Copyright © 2019 Elsevier Inc. All rights reserved.
Similar articles
-
Hebbian Spike-Timing Dependent Plasticity at the Cerebellar Input Stage.J Neurosci. 2017 Mar 15;37(11):2809-2823. doi: 10.1523/JNEUROSCI.2079-16.2016. Epub 2017 Feb 10. J Neurosci. 2017. PMID: 28188217 Free PMC article.
-
Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation.Elife. 2017 Jul 10;6:e27756. doi: 10.7554/eLife.27756. Elife. 2017. PMID: 28691903 Free PMC article.
-
Spike timing-dependent plasticity and memory.Curr Opin Neurobiol. 2023 Jun;80:102707. doi: 10.1016/j.conb.2023.102707. Epub 2023 Mar 14. Curr Opin Neurobiol. 2023. PMID: 36924615 Review.
-
An implementation of reinforcement learning based on spike timing dependent plasticity.Biol Cybern. 2008 Dec;99(6):517-23. doi: 10.1007/s00422-008-0265-6. Epub 2008 Oct 22. Biol Cybern. 2008. PMID: 18941775
-
Neuromodulated Spike-Timing-Dependent Plasticity, and Theory of Three-Factor Learning Rules.Front Neural Circuits. 2016 Jan 19;9:85. doi: 10.3389/fncir.2015.00085. eCollection 2015. Front Neural Circuits. 2016. PMID: 26834568 Free PMC article. Review.
Cited by
-
White matter and neurological disorders.Arch Pharm Res. 2020 Sep;43(9):920-931. doi: 10.1007/s12272-020-01270-x. Epub 2020 Sep 25. Arch Pharm Res. 2020. PMID: 32975736 Review.
-
Current Approaches to the Treatment of Post-Stroke Aphasia.J Stroke. 2021 May;23(2):183-201. doi: 10.5853/jos.2020.05015. Epub 2021 May 31. J Stroke. 2021. PMID: 34102754 Free PMC article. Review.
-
Astrocytes in Pain Perception: A Systems Neuroscience Approach.Adv Neurobiol. 2024;39:193-212. doi: 10.1007/978-3-031-64839-7_8. Adv Neurobiol. 2024. PMID: 39190076 Review.
-
Dynamics of phase oscillator networks with synaptic weight and structural plasticity.Sci Rep. 2022 Sep 2;12(1):15003. doi: 10.1038/s41598-022-19417-9. Sci Rep. 2022. PMID: 36056151 Free PMC article.
-
Sleep, plasticity, and sensory neurodevelopment.Neuron. 2022 Oct 19;110(20):3230-3242. doi: 10.1016/j.neuron.2022.08.005. Epub 2022 Sep 8. Neuron. 2022. PMID: 36084653 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
