Plasticity of intrinsic neuronal excitability
- PMID: 30243042
- DOI: 10.1016/j.conb.2018.09.001
Plasticity of intrinsic neuronal excitability
Abstract
Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a certain level of input-specificity or cell-specificity. We discuss here the nature of the learning rules shared by intrinsic and synaptic plasticity and the impact of intrinsic plasticity on temporal processing.
Copyright © 2018 Elsevier Ltd. All rights reserved.
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