Cerebellar inhibitory input to the inferior olive decreases electrical coupling and blocks subthreshold oscillations
- PMID: 24656256
- DOI: 10.1016/j.neuron.2014.02.032
Cerebellar inhibitory input to the inferior olive decreases electrical coupling and blocks subthreshold oscillations
Abstract
GABAergic projection neurons in the cerebellar nuclei (CN) innervate the inferior olive (IO) that in turn is the source of climbing fibers targeting Purkinje neurons in the cerebellar cortex. Anatomical evidence suggests that CN synapses modulate electrical coupling between IO neurons. In vivo studies indicate that they are also involved in controlling synchrony and rhythmicity of IO neurons. Here, we demonstrate using virally targeted channelrhodopsin in the cerebellar nucleo-olivary neurons that synaptic input can indeed modulate both the strength and symmetry of electrical coupling between IO neurons and alter network activity. Similar synaptic modifications of electrical coupling are likely to occur in other brain regions, where rapid modification of the spatiotemporal features of the coupled networks is needed to adequately respond to behavioral demands.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment in
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Modulation of electrotonic coupling in the inferior olive by inhibitory and excitatory inputs: integration in the glomerulus.Neuron. 2014 Mar 19;81(6):1215-1217. doi: 10.1016/j.neuron.2014.03.009. Neuron. 2014. PMID: 24656244
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