Review
doi: 10.1038/nrm2249.
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
Affiliations
- PMID: 17712357
- DOI: 10.1038/nrm2249
Item in Clipboard
Review
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
Nat Rev Mol Cell Biol.
2007 Oct.
Abstract
The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells. The kinases are heterotrimers that comprise a catalytic subunit and regulatory subunits that sense cellular energy levels. When energy status is compromised, the system activates catabolic pathways and switches off protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells.
Similar articles
-
The AMP-activated protein kinase: more than an energy sensor.Essays Biochem. 2007;43:121-37. doi: 10.1042/BSE0430121. Essays Biochem. 2007. PMID: 17705797 Review.
-
AMP-activated protein kinase: the energy charge hypothesis revisited.Bioessays. 2001 Dec;23(12):1112-9. doi: 10.1002/bies.10009. Bioessays. 2001. PMID: 11746230 Review.
-
Expression and regulation of the AMP-activated protein kinase-SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits.Biochem J. 2002 Aug 1;365(Pt 3):629-38. doi: 10.1042/BJ20020124. Biochem J. 2002. PMID: 11971761 Free PMC article.
-
The AMP-activated protein kinase cascade--a unifying system for energy control.Trends Biochem Sci. 2004 Jan;29(1):18-24. doi: 10.1016/j.tibs.2003.11.005. Trends Biochem Sci. 2004. PMID: 14729328 Review.
-
[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].Med Sci (Paris). 2006 Apr;22(4):381-8. doi: 10.1051/medsci/2006224381. Med Sci (Paris). 2006. PMID: 16597407 Review. French.
Cited by
-
Suppression of neuronal AMPKβ2 isoform impairs recognition memory and synaptic plasticity.Neurobiol Dis. 2024 Oct 15;201:106664. doi: 10.1016/j.nbd.2024.106664. Epub 2024 Sep 13. Neurobiol Dis. 2024. PMID: 39278510 Free PMC article.
-
Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action.Int J Mol Sci. 2024 Sep 4;25(17):9593. doi: 10.3390/ijms25179593. Int J Mol Sci. 2024. PMID: 39273552 Free PMC article. Review.
-
Curcumin Inhibits TORC1 and Prolongs the Lifespan of Cells with Mitochondrial Dysfunction.Cells. 2024 Sep 1;13(17):1470. doi: 10.3390/cells13171470. Cells. 2024. PMID: 39273040 Free PMC article.
-
Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis.Sci Rep. 2024 Sep 11;14(1):21275. doi: 10.1038/s41598-024-72309-y. Sci Rep. 2024. PMID: 39261583 Free PMC article.
-
Chemotherapy and Metabolic Syndrome: A Comprehensive Review of Molecular Pathways and Clinical Outcomes.Cureus. 2024 Aug 7;16(8):e66354. doi: 10.7759/cureus.66354. eCollection 2024 Aug. Cureus. 2024. PMID: 39246917 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
