Organelle degradation during the lens and erythroid differentiation is independent of autophagy - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jan 13;339(2):485-9.
doi: 10.1016/j.bbrc.2005.11.044. Epub 2005 Nov 15.

Organelle degradation during the lens and erythroid differentiation is independent of autophagy

Makoto Matsui  1 , Akitsugu Yamamoto, Akiko Kuma, Yoshinori Ohsumi, Noboru Mizushima
Affiliations

Organelle degradation during the lens and erythroid differentiation is independent of autophagy

Makoto Matsui et al. Biochem Biophys Res Commun. .

Abstract

Autophagy is a bulk degradation system within cells through which cytoplasmic components are degraded within lysosomes. Primary roles of autophagy are starvation adaptation and intracellular protein quality control. In contrast to the ubiquitin-proteasome system, autophagy can also degrade organelles. Here we examined a possible role of autophagy in organelle degradation during lens and erythroid differentiation. We observed that autophagy occurs in embryonic lens cells. However, organelle degradation in lens and erythroid cells occurred normally in autophagy-deficient Atg5(-/-) mice. Our data suggest that degradation system(s) other than autophagy play major roles in organelle degradation during these processes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources