Centractinとは 意味・読み方・使い方

Centractin also known as ARP1 (Actin Related Protein-1) is a protein found in the centrosome and is a homologue of the eukaryotic protein actin. ARP1 forms a 37 nm filament-like structure and is the core of the dynactin complex, an essential activator of cytoplasmic dynein-driven vesicle movement. It only exists in the dynactin complex in vivo. Highly purified, native Arp1 polymerize rapidly at extremely low concentrations into short filaments in vitro that were similar, but not identical, in length to those in dynactin. With time, these Arp1 filaments appeared to anneal to form longer assemblies but never attained the length of conventional actin filaments. As for conventional actin, Arp1 can bind and hydrolyze ATP, and Arp1 assembly is accompanied by nucleotide hydrolysis. It has been reported that Arp1 interacts with other dynactin components including DCTN1/p150^Glued, DCTN4/p62 and Actr10/Arp11. Arp1 has been shown as the domain for dynactin binding to membrane vesicles (such as Golgi or late endosome) through its association with β-spectrin.