The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure

Title:The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure

Volume: 10 Issue: 4

Author(s): Kota Matsuki, Catherine K. Hathaway, Marlon G. Lawrence, Oliver Smithies and Masao Kakoki

Affiliation:

Keywords: Corticosteroid, collecting duct, epithelial sodium channel, endothelin, nitric oxide.

Abstract: Although human association studies suggest a link between polymorphisms in the gene encoding transforming growth factor (TGF) β1 and differing blood pressure levels, a causative mechanism for this correlation remains elusive. Recently we have generated a series of mice with graded expression of TGFβ1, ranging from approximately 10% to 300% compared to normal. We have found that blood pressure and plasma volume are negatively regulated by TGFβ1. Of note, the 10% hypomorph exhibits primary aldosteronism and markedly impaired urinary excretion of water and electrolytes. We here review previous literature highlighting the importance of TGFβ signaling as a natriuretic system, which we postulate is a causative mechanism explaining how polymorphisms in TGFβ1 could influence blood pressure levels.

Cite this article as:

Matsuki Kota, Hathaway K. Catherine, Lawrence G. Marlon, Smithies Oliver and Kakoki Masao, The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure, Current Hypertension Reviews 2014; 10 (4) . https://dx.doi.org/10.2174/157340211004150319123313