This paper presents the preliminary findings of developing and evaluating a Lean Six Sigma (LSS) e-learning aimed at empowering healthcare professionals in different roles to make healthcare more sustainable. The e-learning was developed with experienced trainers and LSS experts by combining traditional LSS and environmental practices. Participants found the training engaging and confirmed they felt motivated and prepared to start applying the acquired skills and knowledge. We are now following the 39 participants to further investigate the effectiveness of LSS for mitigating the climate challenge in healthcare.