IOS Press Ebooks - Participatory Design of a Clinical Trial Eligibility Criteria Simplification Method
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Participatory Design of a Clinical Trial Eligibility Criteria Simplification Method
Yilu Fang, Jae Hyun Kim, Betina Ross Idnay, Rebeca Aragon Garcia, Carmen E. Castillo, Yingcheng Sun, Hao Liu, Cong Liu, Chi Yuan, Chunhua Weng
984 - 988
10.3233/SHTI210325
Research Article
Studies in Health Technology and Informatics
Volume 281: Public Health and Informatics
Abstract

Clinical trial eligibility criteria are important for selecting the right participants for clinical trials. However, they are often complex and not computable. This paper presents the participatory design of a human-computer collaboration method for criteria simplification that includes natural language processing followed by user-centered eligibility criteria simplification. A case study on the ARCADIA trial shows how criteria were simplified for structured database querying by clinical researchers and identifies rules for criteria simplification and concept normalization.

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