The present study envisages the construction and reforming practice of the national first-class specialty in local colleges under the background of the “New Engineering” project. Specifically, the construction of engineering teaching team, and the construction of practical teaching platform within and out of universities have been explored. Furthermore, the revolution of the teaching method and medium and the cultivation of innovative talents has been discussed. With the implementation of the “New Engineering” reform and other professional construction initiatives, the quality of pharmaceutical engineering education in the School of Pharmacy, Jiangxi Science and Technology Normal University has significantly improved, and the influence and reputation of the specialties has been significantly enhanced. As a result, the Pharmaceutical Engineering major of the Jiangxi Science and Technology Normal University has been rated as a first-class advantage specialty in Jiangxi Province in 2022, and has ranked first in the comprehensive evaluation of majors in Jiangxi Province for two consecutive rounds.