Only once we agree upon our understanding of what words really mean can we debate whether a concept, represented by those words, is or not well represented significantly in specific application. In a previous paper we presented an innovative point of view on deeper wellbeing understanding towards its increased, effective Health Informatics and clinical usage and applications. Medicine was always the art and science of healing. The science became more and more a mechanistic technology; the art was dropped altogether. Uncertainty-as-problem in the past is slowly morphing into the evolutive concept of uncertainty-as-resource. The key change performance factor is education, distinguishing from classic, contemporary education and a new one, based on a more reliable control of learning uncertainty. Conceptual clarity, more than instrumental obsession (so typical of this particular time) is necessary. In this paper, we present the main concepts of fundamental biomedical enhanced knowledge formalisation for Health Informatics and Wellbeing of the future.