In the recent years, there has been a strong trend of using social media by the patients, carers, and practitioners to support chronic care management decisions. Studies also show that social media have promising potentials in this area; however, the findings from our exploratory study suggested that there are yet many uncertainties and barriers perceived around the usefulness of using social media for healthcare decision making. The purpose of this study is to explore and unravel the barriers of using social media in the management of chronic disease. We argue that sociomaterial perspective provides a new way of understanding the relation between technology and human decision-making in a complex social phenomenon such as the management of chronic disease.