Understanding the Origins of Bacterial Resistance to Aminoglycosides through Molecular Dynamics Mutational Study of the Ribosomal A-Site
Figure 9
Hydrogen bonds formed by paromomycin with the RNA.
Distances between the atoms of the U1406·U1495 pair and paromomycin as a function of the simulation time along with the trajectory snapshots labeling the measured distances. Data taken from simulations (a)–(b) G1491A_PAR and (c)–(f) U1406C/U1495A_PAR. Two plots depict values for the two A-sites of the crystal structure.