Quantra reproduces BI-RADS assessment on a two-point scale

Ernest U. Ekpo; Claudia Mello-Thoms; Mary Rickard; Patrick C. Brennan; Mark F. McEntee

doi:10.1117/12.2205391

24 March 2016 Quantra reproduces BI-RADS assessment on a two-point scale

Ernest U. Ekpo, Claudia Mello-Thoms, Mary Rickard, Patrick C. Brennan, Mark F. McEntee

Proceedings Volume 9787, Medical Imaging 2016: Image Perception, Observer Performance, and Technology Assessment; 978702 (2016) https://doi.org/10.1117/12.2205391
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

PURPOSE: To assess the performance of Quantra^TM in reproducing BI-RADS^® mammographic breast density (MBD) assessment. METHODS: Two methods of MBD assessment were used (Quantra^TM and BI-RADS^®). Volumetric breast density measurement from 292 raw projection images was performed using Quantra^TM. BI-RADS^® assessment was performed by three radiologists and a majority report (consensus of at least two radiologists) was generated. Interreader agreement (κ), agreement, and the sensitivity and specificity of Quantra^TM in reproducing BI-RADS^® rating were calculated on a four-grade (1, 2, 3, and 4) and two-grade (1–2 vs. 3–4) scale. RESULTS: The majority BI-RADS^® report in the dataset consisted of 9.6% (n = 28), 35.3% (n = 103), 27.1% (n = 79), and 28.1% (n = 82) for BI-RADS® 1, 2, 3, and 4 respectively. Intra-reader agreement (κ) was 0.86 (95%CI: 0.83 – 0.91) to 0.88 (95%CI: 0.85 – 0.93) on a four-grade and 0.88 (95%CI: 0.83 – 0.92) to 0.91 (95%CI: 0.88 – 0.95) on a two-grade scale. Inter-reader agreement (κ) was substantial [0.66 (95%CI: 0.62 – 0.71) to 0.75 (95%CI: 0.70 – 0.81)] on a four-grade scale and substantial to almost perfect [0.77 (95%CI: 0.73 – 0.82) to 0.89 (95%CI: 0.84 – 0.93)] on a two-grade scale. Quantra^TM correctly classified 35.7%, 91.2%, 88.6%, and 50.3% of BI-RADS^® 1, 2, 3, and 4 respectively. It also demonstrated 91.3% sensitivity and 83.6% specificity in reproducing BI-RADS^® on a two-grade scale (1–2 vs. 3–4). CONCLUSION: Quantra^TM has limited performance in reproducing BI-RADS^® rating on a four-grade scale, however, highly reproduces BI-RADS^® assessment on a two-grade scale.

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Ernest U. Ekpo, Claudia Mello-Thoms, Mary Rickard, Patrick C. Brennan, and Mark F. McEntee "Quantra reproduces BI-RADS assessment on a two-point scale", Proc. SPIE 9787, Medical Imaging 2016: Image Perception, Observer Performance, and Technology Assessment, 978702 (24 March 2016); https://doi.org/10.1117/12.2205391

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KEYWORDS

Model-based design

Tissues

Breast cancer

Mammography

Cancer

Digital breast tomosynthesis

Magnetic resonance imaging

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