Abstract
The scientific development of 3D bioprinting is rapidly advancing. This innovative technology involves many ethical and regulatory issues, including theoretical, source, transplantation and enhancement, animal welfare, economic, safety and information arguments. 3D bioprinting technology requires an adequate bioethical debate in order to develop regulations in the interest both of public health and the development of research. This paper aims to initiate and promote ethical debate. The authors examine scientific aspects of 3D bioprinting technology and explore related ethical issues, with special regard to the protection of individual rights and transparency of research. In common with all new biotechnologies, 3D bioprinting technology involves both opportunities and risks. Consequently, several scientific and ethical issues need to be addressed. A bioethical debate should be carefully increased through a multidisciplinary approach among experts and also among the public.
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Al-Ramahi, J., Luo, H., Fang, R., Chou, A., Jiang, J., & Kille, T. (2016). Development of an Innovative 3D Printed Rigid Bronchoscopy Training Model. Annals of Otology, Rhinology & Laryngology, 125(12), 965–969.
Annas, G. J. (2017). Cure research and consent: the Mississippi Baby, Barney Clark, Baby Fae and Martin Delaney. Journal of Medical Ethics, 43(2), 104–107.
Baldelli, I., Massaro, A., Penco, S., Bassi, A. M., Patuzzo, S., & Ciliberti, R. (2017). Conscientious objection to animal experimentation in Italian Universities. Animals Basel, 7(3), 24.
Balistreri, M. (2011). Superumani. Etica ed Enhancement. Torino: Espress.
Barron, J. A., Wu, P., Ladouceur, H. D., & Ringeisen, B. R. (2004). Biological laser printing: a novel technique for creating heterogeneous 3-dimensional cell patterns. Biomedical Microdevices, 6(2), 139–147.
Bourret, R., Martinez, E., Vialla, F., Giquel, C., Thonnat-Marin, A., & De Vos, J. (2016). Human-animal chimeras: ethical issues about farming chimeric animals bearing human organs. Stem Cell Research Therapy, 7(1), 87.
Busardò, F. P., Gulino, M., Napoletano, S., Zaami, S., & Frati, P. (2014). The Evolution of Legislation in the Field of Medically Assisted Reproduction and Embryo Stem Cell Research in European Union Members. Biomed Research Interntional 307160.
Chan, S., & Harris, J. (2011). Moral Enhancement and Pro-Social Behavior. Journal of Medical Ethics, 37(3), 130–131.
Ciliberti, R., Martini, M., Bonsignore, A., & Penco, S. (2016). Break with tradition: donating cadavers for scientific purposes and reducing the use of sentient beings. Annali dell’Istituto Superiore di Sanità, 52(2), 261–268.
Condic, M. L. (2013). When Does Human Life Begin? The Scientific Evidence and Terminology Revisited, University of St. Thomas Journal of Law and Public Policy, vol. 8, Issue 1 Fall 2013, art. 4. Retrieved from http://www.embryodefense.org/MaureenCondicSET.pdf.
Cornwall, J. (2016). The ethics of 3D-printing copies of bodies donated for medical education and research: What is there to worry about? The Australasian Medical Journal, 9(1), 8–11.
Cui, X., & Boland, T. (2009). Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials, 30(31), 6221–6227.
Cui, H., Zhu, W., Holmes, B., & Zhang, L. G. (2016). Biologically inspired smart release system based on 3D bioprinted perfused scaffold for vascularized tissue regeneration. Advanced Science (Weinh), 3(8), 1600058.
Dabrock, P. (2009). Playing God? Synthetic biology as a theological and ethical challenge. Systems and Synthetic Biology, 3(1–4), 47–54.
De Vos, P., Faas, M. M., Strand, B., & Calafiore, R. (2006). Alginate-based microcapsules for immunoisolation of pancreatic islets. Biomaterials, 27(32), 5603–5617.
Dodds, S. (2015). 3D printing raises ethical issues in medicine. Analysis and Opinion, ABC Science. Retrieved from http://www.abc.net.au/science/articles/2015/02/11/4161675.html.
Engelhardt, H. T. (1995). The Foundations of Bioethics (2nd ed.). New York, Oxford: Oxford University Press.
Fukuyama, F. (2002). Our Posthuman Future: Consequences of the Biotechnology Revolution. New York: Farrar, Strauss and Giroux.
Gasperini, L., Maniglio, D., & Migliaresi, C. (2013). Microencapsulation of cells in alginate through an electrohydrodynamic process. Journal of Bioactive and Compatible Polymers, 28, 413–425.
Gasperini, L., Maniglio, D., Motta, A., & Migliaresi, C. (2014a). An electrohydrodynamic printer for alginate hydrogels containing living cells. Tissue Engineering & Regenerative Medicine International Society, 21, 123–132.
Gasperini, L., Mano, J. F., & Reis, R. L. (2014b). Natural polymers for the microencapsulation of cells. Journal of the Royal Society, Interface, 11(100), 20140817.
Gilbert, F., O’Connell, C. D., Mladenovska, T., & Dodds, S. (2017). Print Me an Organ? Ethical and Regulatory Issues Emerging from 3D Bioprinting in Medicine. Science and Engineering Ethics.
Greasley, K. (2014). A legal market in organs: the problem of exploitation. Journal of Medical Ethics, 40(1), 51–56.
Habermas, J. (2001). Die Zukunft der menschlichen Natur. Auf dem Weg zu einer liberalen Eugenetik? Frankfurt a.M: Suhrkamp Verlag.
Harris, J. (2011). Moral Enhancement and Freedom. Bioethics, 25(2), 102–111.
Isa, N. M., & Shuri, M. F. H. S. (2017). Ethical Concerns About Human Genetic Enhancement in the Malay Science Fiction Novels. Science and Engineering Ethics. doi:10.1007/s11948-017-9887-1.
Jonas, J. (1979). Das Prinzip Verantwortung. Versuch einer Ethik für die technologische Zivilisation. Frankfurt/M: Suhrkamp.
Kapp, M. B. (2006). Ethical and legal issues in research involving human subjects: do you want a piece of me? Journal of Clinical Pathology, 59, 335–339.
Kass, L. (2002). Life, liberty and the defense of dignity. The Challenge for Bioethics. San Francisco: Encounter Books.
Lim, F., & Sun, A. (1980). Microencapsulated islets as bioartificial endocrine pancreas. Science, 210(4472), 908–910.
Lorber, B., Hsiao, W. K., & Martin, K. R. (2016). Three-dimensional printing of the retina. Current Opinion in Ophthalmology, 27(3), 262–267.
Manti, F. (2009). Bios e polis. Etica, Politica, Responsabilità per la vita. Genova: Università degli Studi di Genova.
Maritain, J. (1973). Approches sans entraves. Paris: Fayard.
Martini, M., Penco, S., Baldelli, I., Biolatti, B., & Ciliberti, R. (2015). An ethics for the living world: operation methods of Animal Ethics Committees in Italy. Annali dell’Istituto Superiore di Sanità, 5(3), 244–247.
Mironov, V., Prestwich, G., & Forgacs, G. (2007). Bioprinting living structures. Journal of Materials Chemistry, 17, 2054.
Mironov, V., Visconti, R. P., Kasyanov, V., Forgacs, G., Drake, C. J., & Markwald, R. R. (2009). Organ printing: tissue spheroids as building blocks. Biomaterials, 30(12), 2164–2174.
Molinelli, A., Bonsignore, A., Rocca, G., & Ciliberti, R. (2009). Medical treatment and patient decisional power: The Italian state of the art. Minerva Medica, 100(5), 429–434.
Moroni, L., De Wijn, J., & Van Blitterswijk, C. A. (2006). 3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties. Biomaterials, 27(7), 974–985.
Neely, E. (2015). The Risks of Revolution: Ethical Dilemmas in 3D Printing from a US Perspective. Science and Engineering Ethics, 22(5), 1285–1297.
Patuzzo, S., & Manganotti, P. (2014) Deep brain stimulation in persistent vegetative States: ethical issues governing decision making. Behav Neurol, 641213.
Patuzzo, S., & Pulice, E. (2015). Towards a European code of medical ethics. Ethical and legal issues. Journal of Medical Ethics, 43(1), 41–46.
Ryder, R. D. (2000). Animal Revolution. Changing Attitudes Towards Speciesim. Oxford: Berg.
Sandel, M. J. (2007). The Case Against Perfection: Ethics in the Age of Genetic Engineering. Cambridge, Mass: Belknap Press of Harvard University Press.
Shen, C., Meng, Q., & Zhang, G. (2014). Design of 3D printed insert for hanging culture of Caco-2 cells. Biofabrication, 17(1), 015003.
Singer, P. (1990). Animal Liberation (Revisited ed.). London: Thorsons.
Tran, J. L. (2015). To bioprint or not to bioprint. The North Carolina Journal of Law & Technology, 17(1), 123–178.
Ventola, C. L. (2014). Medical Applications for 3D Printing: Current and Projected Uses. P and T Pharmacy and therapeutics, 39(10), 704–711.
Vermeulen, N., Haddow, G., Seymour, T., Faulkner-Jones, A., & Shu, W. (2017) 3D bioprint me: a socioethical view of bioprinting human organs and tissues. J Med Ethics. pii: medethics-2015-103347.
Vijayavenkataraman, S. (2016). A Perspective on Bioprinting Ethics. Artificial Organs, 40(11), 1033–1038.
Viola, F. (2010). Umano e post-umano: la questione dell’identità. Roma: Armando.
Walther, G. (2015). Printing Insecurity? The Security Implications of 3D-Printing of Weapons. Science and Engineering Ethics, 21(6), 1435–1445.
Wengerter, B. C., Emre, G., Park, J. Y., & Geibel, J. (2016). Three-dimensional Printing in the Intestine. Clinical Gastroenterology and Hepatology, 14(8), 1081–1085.
Xu, T., Zhao, W., Zhu, J. M., Albanna, M. Z., Yoo, J. J., & Atala, A. (2013). Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology. Biomaterials, 34(1), 130–139.
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Patuzzo, S., Goracci, G., Gasperini, L. et al. 3D Bioprinting Technology: Scientific Aspects and Ethical Issues. Sci Eng Ethics 24, 335–348 (2018). https://doi.org/10.1007/s11948-017-9918-y
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DOI: https://doi.org/10.1007/s11948-017-9918-y