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Accuracy of computer-aided diagnosis based on narrow-band imaging endocytoscopy for diagnosing colorectal lesions: comparison with experts

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Abstract

Purpose

Real-time characterization of colorectal lesions during colonoscopy is important for reducing medical costs, given that the need for a pathological diagnosis can be omitted if the accuracy of the diagnostic modality is sufficiently high. However, it is sometimes difficult for community-based gastroenterologists to achieve the required level of diagnostic accuracy. In this regard, we developed a computer-aided diagnosis (CAD) system based on endocytoscopy (EC) to evaluate cellular, glandular, and vessel structure atypia in vivo. The purpose of this study was to compare the diagnostic ability and efficacy of this CAD system with the performances of human expert and trainee endoscopists.

Methods

We developed a CAD system based on EC with narrow-band imaging that allowed microvascular evaluation without dye (ECV-CAD). The CAD algorithm was programmed based on texture analysis and provided a two-class diagnosis of neoplastic or non-neoplastic, with probabilities. We validated the diagnostic ability of the ECV-CAD system using 173 randomly selected EC images (49 non-neoplasms, 124 neoplasms). The images were evaluated by the CAD and by four expert endoscopists and three trainees. The diagnostic accuracies for distinguishing between neoplasms and non-neoplasms were calculated.

Results

ECV-CAD had higher overall diagnostic accuracy than trainees (87.8 vs 63.4%; \(P=0.01\)), but similar to experts (87.8 vs 84.2%; \(P=0.76\)). With regard to high-confidence cases, the overall accuracy of ECV-CAD was also higher than trainees (93.5 vs 71.7%; \(P<0.001\)) and comparable to experts (93.5 vs 90.8%; \(P=0.38\)).

Conclusions

ECV-CAD showed better diagnostic accuracy than trainee endoscopists and was comparable to that of experts. ECV-CAD could thus be a powerful decision-making tool for less-experienced endoscopists.

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Abbreviations

EC:

Endocytoscopy

CAD:

Computer-aided diagnosis

CRC:

Colorectal cancer

SSA/P:

Sessile serrated adenoma/polyp

ECV-CAD:

CAD system for endocytoscopic vascular pattern

NBI:

Narrow-band imaging

NPV:

Negative predictive value

PPV:

Positive predictive value

CI:

Confidence interval

SVM:

Support vector machine

ASGE:

American Society for Gastrointestinal Endoscopy

PIVI:

Preservation and Incorporation of Valuable Endoscopic Innovations

ROI:

Region of interest

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Acknowledgements

This study was funded by grants from JSPS KAKENHI (Grant Numbers 25860564 and 15K19351). We would like to express our gratitude to Mr. Takashi Wakisaka and Mr. Hideo Kahara (Cybernet Systems Co., Ltd.).

Author information

Authors and Affiliations

  1. Digestive Disease Center, Showa University, Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki, Yokohama, 224-8503, Japan

    Masashi Misawa, Shin-ei Kudo, Yuichi Mori, Kenichi Takeda, Yasuharu Maeda, Shinichi Kataoka, Hiroki Nakamura, Toyoki Kudo, Kunihiko Wakamura, Takemasa Hayashi, Atsushi Katagiri, Toshiyuki Baba & Fumio Ishida

  2. Digestive Disease Center, Showa University, Koto-Toyosu Hospital, Tokyo, Japan

    Haruhiro Inoue

  3. Locus Logic, Inc., Nagoya, Japan

    Yukitaka Nimura

  4. Graduate School of Information Science, Nagoya University, Nagoya, Japan

    Msahiro Oda

  5. Information and Communications, Nagoya University, Nagoya, Japan

    Kensaku Mori

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  1. Masashi Misawa
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  2. Shin-ei Kudo
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Corresponding author

Correspondence to Masashi Misawa.

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Conflict of interest

K Mori received research funding from Cybernet System Company and Olympus Company. H Inoue received a lecture fee from Olympus Company. The other authors declare no conflicts of interest.

Ethical approval

Informed consent was obtained from all study participants, and the study was approved by the Ethical Committee of Showa University (No. 1507-08). All procedures performed in this study involving human participants were in accordance with the ethical standards of the Ethical Committee of Showa University and with the 1964 Helsinki Declaration and its later amendments.

Patents

Japan patent JP 2015-036771 (patent pending) and JP 2015-200803 (patent pending).

Additional information

The results of this study were presented at JAMIT 2015, Kanazawa, and UEGweek 2016, Vienna.

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Misawa, M., Kudo, Se., Mori, Y. et al. Accuracy of computer-aided diagnosis based on narrow-band imaging endocytoscopy for diagnosing colorectal lesions: comparison with experts. Int J CARS 12, 757–766 (2017). https://doi.org/10.1007/s11548-017-1542-4

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  • DOI: https://doi.org/10.1007/s11548-017-1542-4

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