Feasible Preparation of Naphthalimide-Functionalized Zeolitic Imidazolate Framework-8 for Control, and Fluorescence Detection of Virus: Optimization of Model Study | Journal of Fluorescence Skip to main content
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Feasible Preparation of Naphthalimide-Functionalized Zeolitic Imidazolate Framework-8 for Control, and Fluorescence Detection of Virus: Optimization of Model Study

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Abstract

The onset of the coronavirus has highlighted the critical need to swift diagnostic techniques to identify the virus. Metal Organic Frameworks (MOFs) have attracted considerable attention in the field of sensing due to the remarkable characteristics. The present research examines the microwave preparation of naphthalimide-functionalized zeolitic imidazolate framework-8 (NI/ZIF-8) to the detection of coronavirus as a probe. The microwave synthesis approach facilitates an environmentally sustainable, and effective production of NI/ZIF-8. Characterization techniques have validated the material’s high crystallinity and thermal behaviour. In order to enhance the performance of the probe, a 23 factorial model is implemented. This model facilitates the influences of control parameters, including NI/ZIF-8 dose, solution temperature, and buffer pH, on quenching response. The findings indicate the 27 °C, pH 8.2, and a NI/ZIF-8 dose of 0.6 mg/mL yields the maximum quenching response (83.21%). Additionally, it has been determined that photo electron transfer plays a significant role within the quenching process. The sensor demonstrated remarkable sensitivity to the COVID-19 RNA, achieving an exceptionally detection limit of 5.45 pM and a quick sense (20 min), alongside a high detection selectivity of RNA. This project underscores the applicability of NI/ZIF-8 as an effective and eco-friendly sustainable substance for the rapid and accurate detection of RNA of COVID-19.

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Funding

The authors extend their appreciation to the Researchers Supporting Project number (RSP2024R500), King Saud University, Riyadh, Saudi Arabia. The work was supported by Kazan Federal University Strategic Academic Leadership Program (PRIORITY-2030).

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Authors and Affiliations

  1. Department of Botany and Microbiology, College of Science, King Saud University, P.O. 2455, Riyadh, 11451, Saudi Arabia

    Hind A. Al-Shwaiman & Asad Syed

  2. Alexander Butlerov Institute of Chemistry, Kazan Federal University, 1/29 Lobachevskogo Str, Kazan, 420008, Russian Federation

    Rustem R. Zairov

  3. Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University Chennai, Chennai, Tamil Nadu, India

    Manjula Subramaniam

  4. Department of Chemistry, University Centre for Research & Development, Chandigarh University Gharuan, Mohali, Punjab, India

    Meenakshi Verma

  5. Department of Chemistry, Academy of Materials Science, Navi Mumbai, India

    Baadal Jushi Janani & Ramadan Fallah Amer

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  1. Hind A. Al-Shwaiman
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  2. Rustem R. Zairov
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Contributions

Hind A. AL-Shwaiman: Investigation, Methodology, Formal analysis, Funding acquisition, Rustem R. Zairov: Validation; Software; Data curation; Investigation; Formal analysis, Asad Syed: Methodology, Formal analysis, Writing – original draft, Writing – review & editing, Funding acquisition, Manjula Subramaniam: Validation; Software; Data curation; Investigation; Formal analysis, Meenakshi Verma: Validation; Software; Data curation; Investigation; Formal analysis, Baadal Jushi Janani: Formal analysis; Project administration; review & editing; Supervision, Ramadan Fallah Amer: Validation; Software; Data curation; Investigation; Formal analysis.

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Correspondence to Asad Syed or Baadal Jushi Janani.

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Al-Shwaiman, H.A., Zairov, R.R., Syed, A. et al. Feasible Preparation of Naphthalimide-Functionalized Zeolitic Imidazolate Framework-8 for Control, and Fluorescence Detection of Virus: Optimization of Model Study. J Fluoresc (2024). https://doi.org/10.1007/s10895-024-04042-8

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